Osteoporosis affects millions of postmenopausal women in the United States alone. For white women who reach 50 years of age, the lifetime risk of vertebral fracture is about one in three, and that for hip fracture is one in six. One tenth to one fifth of ...

Inhibitory antibodies to factor VIII arise in more than 20 percent of patients with hemophilia A who receive replacement therapy with factor VIII protein.¹ Since these antibodies profoundly complicate the treatment of hemophilia, understanding how they ...

To the Editor: I am surprised that the target systolic blood pressures in three studies of the renoprotective effects of angiotensin-receptor blockers in patients with type 2 diabetes (Sept. 20 issue)¹–³ exceeded the threshold of less than 130 mm Hg ...

To the Editor: Herndon et al. (Oct. 25 issue)¹ report that propranolol attenuates hypermetabolism and reverses muscle-protein catabolism in patients with severe burns. However, these conclusions must be critically examined, because the findings may be ...

To the Editor: Mange et al. (Oct. 25 issue)¹ report on the survival of shipped and locally transplanted cadaveric renal allografts. On the basis of their findings, the authors conclude that national shipment of such allografts “increases the risk of ...

To the Editor: In his article on essential tremor (Sept. 20 issue),¹ Louis does not mention alcohol. Ethanol in small doses usually stops the tremor, and this finding may be useful in diagnosis. Some people may use ethanol to hide their tremor; they risk ...

To the Editor: The review of Tourette's syndrome by Jankovic (Oct. 18 issue)¹ contains a Venn diagram (Figure 1 of the article) that may be misleading. The figure suggests that Tourette's syndrome lies at the intersection of tics, attention-deficit–...

To the Editor: Reviews of the accomplishments in the fight against the human immunodeficiency virus (HIV) such as those in the June 7 issue¹–³ cannot help but sound self-congratulatory when there are more than 30 million people with untreated AIDS — a ...

To the Editor: There is no clearly established strategy for the treatment of a patient with cardiomyopathy and a symptomatic aneurysm of the thoracic aorta. We report the successful use of an approach combining aortic surgery and the implantation of a ...

To the Editor: Chronic myelomonocytic leukemia and myelofibrosis with myeloid metaplasia are hematopoietic stem-cell disorders for which there is no effective drug therapy. Imatinib mesylate (Gleevec, Novartis, Basel, Switzerland), formerly known as ...

A variety of hematologic cancers have served as examples of how to cure the disease by a step-by-step application of new treatments as they become available, but it must be admitted that during the past 10 years there have been no real breakthroughs in ...

Hepatobiliary Diseases: Pathophysiology and Imaging was edited by two Japanese professors of medicine, one American professor of radiology, and one Japanese professor of radiology. Most of the 23 contributing authors are Japanese; 1 is a pathologist and ...

The discovery of prostate-specific antigen (PSA), a serine protease, was one of the most important accomplishments in urologic oncology in the past 15 years. In a relatively short time and in an extraordinary way, this tumor marker affected virtually all ...

Prothrombotic Coagulation Abnormalities Preceding the Hemolytic–Uremic Syndrome Original Article, N Engl J Med 2002:346;23-32.. On page 32, the grant support was omitted. It should have read, “Supported by National Institutes of Diabetes and Kidney ...

In June 2001, Ellen Roche, a healthy young technician at the Johns Hopkins Asthma and Allergy Center, died during an asthma study. The tragedy prompted several intensive investigations of research oversight at Johns Hopkins and led to the temporary suspension of all federally funded research projects at the institution. In this Health Policy Report, Steinbrook provides a detailed discussion of the outcome of the investigations, the response from Johns Hopkins, and the wider lessons for all involved in clinical investigation.