Chronic hepatitis B remains a major public health problem, affecting more than 350 million people worldwide. Cirrhosis, liver failure, or hepatocellular carcinoma will develop in approximately 15 to 40 percent of infected patients.

The worldwide ...

Imagine a nephrologist with no biopsy needle, no imaging techniques, no serum creatinine measurement — a nephrologist whose patients need dialysis when they first present for care. This is the predicament of the diabetologist, whose patients with type 1 ...

The mast cell has long been considered to be of paramount importance in the pathophysiology of asthma. Its key role in driving the IgE-mediated allergic reaction and thus the early asthmatic response is well documented. In addition, there is evidence that ...

To the Editor: The report by Walsh et al. (Jan. 24 issue)¹ of a trial of voriconazole, as compared with liposomal amphotericin B, for patients with neutropenia and persistent fever and the accompanying editorial and letter to the editor²,³ leave many ...

To the Editor: Dalakas et al. (Dec. 27 issue)¹ report the efficacy of high-dose intravenous immune globulin for the treatment of stiff-person syndrome. Stiff-person syndrome is a devastating disorder, and evidence of the associated immunologic impairment ...

To the Editor: Seufert et al. (Dec. 27 issue)¹ describe a man with tumor-induced (oncogenic) osteomalacia, in which the subcutaneous administration of octreotide abolished renal tubular phosphate wasting. The authors suggest that in patients who cannot ...

To the Editor: The article by Zinkernagel (Nov. 1 issue)¹ and the accompanying editorial² discuss the attractive and popular notion that the occurrence of fewer infectious diseases during childhood leads to an increase in the incidence of autoimmune ...

To the Editor: The case discussion by Nutman and Kradin (Jan. 10 issue)¹ triggered the recollection of a case of Loa loa infection that I saw years ago as a Peace Corps physician in Cameroon, West Africa. A healthy young man noted migratory arthralgia of ...

To the Editor: Case 4-2002 (Jan. 31 issue) described a 75-year-old man with acute renal failure five months after cystoprostatectomy and urethrectomy for carcinoma.¹ Recently, we cared for a 52-year-old woman who had acute renal failure after surgery for ...

To the Editor: The management of disseminated carcinoma of the cervix that is no longer amenable to control with surgery or radiation therapy has not improved significantly with the advent of modern chemotherapy. The one-year survival rate remains ...

To the Editor: Acute dystonic reactions have been reported after the ingestion of numerous medications that alter dopaminergic tone in the basal ganglia or antagonize dopamine D2 receptors. At the emergency department of an urban community hospital, we ...

Hippocrates said, “Let food be your medicine,” and hundreds of Internet sites echo his maxim, usually as part of a sales pitch for supplements, pet foods, or other products. Diet was indeed the cornerstone of medical practice for some 2000 years, but for ...

Organ transplantation is now a widely accepted treatment for a variety of end-stage diseases. Once practiced by and offered to an elite few, transplantation has permeated our professional and social conscience. Articles and stories about transplantation ...

Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest Original Article, N Engl J Med 2002:346;549-556.. On line 13 of the Appendix, “Takunen” should have been spelled “Takkunen.”

Prevalence of Impaired Glucose Tolerance among Children and Adolescents with Marked Obesity Original Article, N Engl J Med 2002:346;802-810.. On line 2 of the Methods section of the Abstract, the dose of glucose should have been “1.75 g of glucose per ...

What is exceptional in nursing is the nature of the work: the continuous and intimate association with pain and not infrequent contact with death. . . . Not every man or woman would feel themselves able to undertake the duties of a nurse.

Brian Abel-Smith,...