The spectrum of acute mountain sickness ranges from mild, nonspecific symptoms to high-altitude pulmonary edema and high-altitude cerebral edema. Most deaths from high-altitude illness occur with high-altitude pulmonary edema, the risk of which is related ...

Recent years have witnessed explosive growth in knowledge of the physiologic factors regulating appetite and body weight.¹ Among these are neural, metabolic, and endocrine signals from the periphery that reflect the short- and long-term status of energy ...

During the past decade, patients with the uncommon disease amyotrophic lateral sclerosis (ALS) have had a prominent role in the debate about physician-assisted suicide and voluntary active euthanasia. In Canada and Great Britain, patients with ALS have ...

To the Editor: I would like to propose a hypothesis that may account for the findings of Borghi et al. (Jan. 10 issue).¹ The low-protein, low-salt diet they studied may have reduced the urinary monosodium urate concentration. An increase in urinary ...

To the Editor: In their article in the January 10 issue, Shore et al. report that they identified heterozygous inactivating GNAS1 mutations in 13 of 18 probands in six families with progressive osseous heteroplasia (POH).¹ The defective allele in their ...

To the Editor: Booton and Jacob (Jan. 10 issue)¹ present an elegant and illustrative case of bronchioloalveolar carcinoma (also referred to as bronchoalveolar-cell carcinoma) of the lung. However, their statement that a “transbronchial biopsy led to the ...

To the Editor: Ransohoff and Sandler (Jan. 3 issue)¹ underestimate the cost of colonoscopy. Medicare reimbursement to the physician may average $380, but the total cost is much higher if reimbursement to health care professionals and the hospital are ...

To the Editor: The review by Annas of the new federal regulations for medical privacy and medical research (Jan. 17 issue)¹ made it clear that there must be a mechanism to protect the privacy of patients. However, there has been a major effort over the ...

To the Editor: We report the development of hyperammonemic encephalopathy in a patient with multiple myeloma.

A 43-year-old woman with stage IIIA light-chain multiple myeloma presented to the hospital with lethargy and a left molar mass. She had not ...

To the Editor: Spinning is an aerobic activity performed on a stationary bicycle and carried out in groups in enclosed rooms, with instructors increasing and intensifying the workout by varying the resistance of the bike, altering the pace, or “jumping,” ...

Several decades ago, most patients with uncorrected or corrected congenital heart disease did not survive to adulthood. As a result, they were cared for almost exclusively by pediatricians and pediatric cardiologists. Cardiologists trained to care for ...

Public awareness of prostate cancer has substantially increased over the past decade. Screening based on the measurement of prostate-specific antigen in serum has revolutionized the detection and management of prostate cancer. Therapeutic options include ...

Paternally Inherited Inactivating Mutations of the GNAS1 Gene in Progressive Osseous Heteroplasia Original Article, N Engl J Med 2002:346;99-106.. Line 2 of the legend for Figure 3 should have read, “mutated GNAS1 genomic DNA from patients” rather than “...

Protecting Research Subjects — The Crisis at Johns Hopkins Health Policy Report, N Engl J Med 2002:346;716-720.. Table 1, “Suspensions of Federally Supported Research,” should have included the following entry: “September 1999” in the column entitled “...