Join the 200th Anniversary Celebration

Issue IndexA searchable index of tables of contents

Find An Issue

By Volume and Issue
By Date

Table of contents for

January 10, 2002  Vol. 346 No. 2

Perspective
74-76

    Kidney and bladder stones cause excruciating pain, tend to recur, and are distressingly common. Roughly 10 percent of persons in the United States will have at least one stone in the course of their lives. The disorder has a long history. Stones have been ...

    Original Articles
    77-84

    This randomized trial, involving men with recurrent calcium oxalate stones and hypercalciuria, compared the effectiveness of a low-calcium diet with one containing a normal amount of calcium but restricted amounts of animal protein and salt. After five years, only 12 of the 60 men on the diet with normal calcium, low animal protein, and low salt had recurrent stones, as compared with 23 of the 60 men on the low-calcium diet (relative risk of a recurrence among those on the normal-calcium, low-protein, low-salt diet, 0.49; 95 percent confidence interval, 0.24 to 0.98; P=0.04).

    85-91

    In this randomized trial, irinotecan plus cisplatin was compared with etoposide plus cisplatin for the treatment of metastatic small-cell lung cancer. The trial was stopped early because of a significant difference in survival, in favor of irinotecan plus cisplatin.

    92-98

    Four combinations of chemotherapy were compared in patients with advanced non–small-cell lung cancer. No one regimen appeared to be superior to the others. The overall survival rate at one year was 33 percent. The regimen of carboplatin plus paclitaxel was less toxic than the other regimens.

    99-106

    The rare disease progressive osseous heteroplasia (POH) is characterized by disabling skeletal-muscle and connective-tissue ossification that begins in childhood. It has been proposed that POH might have a common basis with another rare disease associated with extensive heterotopic ossification, Albright's hereditary osteodystrophy (AHO). Since heterozygous inactivating mutations in the GNAS1 gene are known to cause AHO, GNAS1 mutations were sought in subjects with POH. Heterozygous inactivating GNAS1 mutations were found in 13 of 18 probands with POH, all of whom inherited the defective allele exclusively from their fathers — a finding consistent with paternal imprinting.

    Images in Clinical Medicine
    107
    • Free Full Text

    Chest radiography and high-resolution CT led to transbronchial biopsy and the diagnosis of cancer.

    Review Article
    108-114

    In the wake of the terrorist attacks on September 11, 2001, physicians have been confronted with patients who have suffered psychological trauma. This Review Article examines an extreme reaction, the post-traumatic stress disorder, which may follow a variety of traumatic events. The author defines the syndrome, its clinical features, and research findings on its biologic aspects. For patients who require therapy, she discusses both counseling and pharmacologic approaches.

    Case Records of the Massachusetts General Hospital
    115-122

    Presentation of Case

    A 24-year-old woman was admitted to the Travel and Tropical Medicine Center at this hospital because of edema and intermittent paresthesias of the right leg.

    The patient was a volunteer with the Peace Corps. She had traveled to Gabon, ...

    Editorials
    124-125

    Kidney stones have a lifetime incidence of up to 13 percent in North America.1 In the United States, this disorder was responsible for an estimated 1.32 million visits to physicians in 1995 and for $1.83 billion in health care costs in 1993.2 In at least ...

    126-128

    In 2001 lung cancer caused more than 1 million deaths worldwide. Despite the well-recognized link between tobacco use and the development of lung cancer, the number of new cases continues to rise, especially among women. In girls and women 15 to 64 years ...

    128-130

    Important insights into the regulation of mineral-ion homeostasis, cartilage development, and thus bone growth have been obtained through the molecular definition of various genetic disorders. Several of these disorders, most of which are rare, are now ...

    130-132

    Terrorist attacks require our health care system to prepare for the unspeakable. The primary goal of terrorism is to erode the security of a nation, to disrupt the continuity of society, and to destroy the nation's social capital — its morale, cohesion, ...

    Correspondence
    134-137

    To the Editor: Lydon-Rochelle and colleagues (July 5 issue)1 quantify the risk of uterine rupture in a subsequent pregnancy after a first cesarean delivery. Once uterine rupture occurred, the relative risk of the perinatal death of the infant increased ...

    137-138

    To the Editor: Kapiteijn et al. (Aug. 30 issue)1 reported that short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo standardized total mesorectal excision. There was no survival advantage. ...

    138-139

    To the Editor: Dr. Lapostolle and colleagues (Sept. 13 issue)1 offer the best descriptions to date of the epidemiology of pulmonary embolism associated with air travel and of flight distance as a risk factor. There is a problem, however, with the data ...

    139

    To the Editor: The computed tomographic (CT) image of bilateral dermoid cysts (July 26 issue)1 is indeed elegant and illustrative of the disease process. However, it also illustrates the unnecessary use of an expensive form of technology when a less ...

    140

    To the Editor: Anorexia nervosa is sometimes accompanied by self-induced vomiting. Associated electrolyte disturbances such as metabolic alkalosis and hypokalemia1,2 may predispose patients to arrhythmias and can be difficult to treat.

    A 32-year-old ...

    Book Reviews
    141

    “A man shall cleave unto his wife: and they shall be one flesh” (Genesis 2:24) is the unambiguous biblical directive to married men: participate in and enjoy sexual intercourse. Those who could not do so were considered to lack power — to be “impotent” — ...

    141-142

    Few physicians and fewer medical students read novels. Nonetheless, literature has much to teach physicians and medical students about the type of work they have chosen. This anthology, aimed primarily at first-year medical students, is made up of bite-...

    Trends: Most Viewed (Last Week)

    More Trends