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January 10, 2002 Vol. 346 No. 2
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This randomized trial, involving men with recurrent calcium oxalate stones and hypercalciuria, compared the effectiveness of a low-calcium diet with one containing a normal amount of calcium but restricted amounts of animal protein and salt. After five years, only 12 of the 60 men on the diet with normal calcium, low animal protein, and low salt had recurrent stones, as compared with 23 of the 60 men on the low-calcium diet (relative risk of a recurrence among those on the normal-calcium, low-protein, low-salt diet, 0.49; 95 percent confidence interval, 0.24 to 0.98; P=0.04).
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The rare disease progressive osseous heteroplasia (POH) is characterized by disabling skeletal-muscle and connective-tissue ossification that begins in childhood. It has been proposed that POH might have a common basis with another rare disease associated with extensive heterotopic ossification, Albright's hereditary osteodystrophy (AHO). Since heterozygous inactivating mutations in the GNAS1 gene are known to cause AHO, GNAS1 mutations were sought in subjects with POH. Heterozygous inactivating GNAS1 mutations were found in 13 of 18 probands with POH, all of whom inherited the defective allele exclusively from their fathers — a finding consistent with paternal imprinting.
In the wake of the terrorist attacks on September 11, 2001, physicians have been confronted with patients who have suffered psychological trauma. This Review Article examines an extreme reaction, the post-traumatic stress disorder, which may follow a variety of traumatic events. The author defines the syndrome, its clinical features, and research findings on its biologic aspects. For patients who require therapy, she discusses both counseling and pharmacologic approaches.
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