Over the past two decades, percutaneous coronary intervention has revolutionized the treatment of symptomatic coronary artery disease, sparing countless patients the need for surgical revascularization. This year, up to a million procedures are likely to ...

In this issue of the Journal, readers will find a quiz based on the article entitled “Nonalcoholic Fatty Liver Disease,” by Angulo. This marks the beginning of a new continuing-medical-education (CME) program that will feature questions on three of the ...

Infants with severe combined immunodeficiency are unable to mount an adaptive immune response, because they have a profound deficiency of lymphocytes. These babies usually die within a year from a sustained onslaught of opportunistic infections, but death ...

Too often antibiotics, remarkable therapies that can cure deadly and disabling infections, are used to satisfy patients' needs rather than out of clinical necessity. This practice translates into the excessive use of antibiotics for acute respiratory ...

To the Editor: Goodwin et al. (Dec. 13 issue)¹ report that support groups do not improve survival among women with metastatic breast cancer. We applaud this work but would like to raise several issues regarding its goals and conclusions. The ...

To the Editor: Hasbun et al. (Dec. 13 issue)¹ show that in adults with suspected meningitis, clinical findings can guide the decision to perform cranial computed tomography (CT) before lumbar puncture. However, the results should not form the basis for ...

To the Editor: Petersdorf et al. (Dec. 20 issue)¹ suggest that for patients with chronic myelogenous leukemia for whom a donor with an HLA class I mismatch cannot be avoided, “the preferred . . . mismatch should be at a locus for which the recipient is ...

To the Editor: Portal–mesenteric venous thrombosis, a devastating complication of hypercoagulable states, is a good target for minimally invasive treatment. Kumar et al. (Dec. 6 issue)¹ ignored a growing body of work indicating that catheter-based ...

To the Editor: In a 34-year-old woman with a history of alcohol abuse, cardiomyopathy, and AIDS, acute respiratory failure developed as a result of Escherichia coli sepsis and pneumonia. Initial laboratory studies revealed a pH of 7.2, a bicarbonate ...

To the Editor: The popliteal-artery entrapment syndrome is a potentially serious but rare cause of ischemia of the legs.¹ It occurs predominantly in young persons and is due to an abnormal anatomical relation between the popliteal artery and the ...

If you wanted to cause an epidemic of multidrug-resistant tuberculosis in a country, what would you do? First, you would create a social and economic environment that promotes poverty and inequity. Second, you would temporarily subject those who have ...

What is malaria? The answer to this seemingly simple question is, in fact, quite complex, for it depends to a large extent on who is infected. It is particularly difficult for reference books to describe a “typical” patient with malaria, since plasmodium ...

More than 2 billion people worldwide are infected with either hepatitis B virus (HBV) or hepatitis C virus (HCV) or both, and an estimated 500 million (about 3 million in the United States alone) have chronic infection with these viruses. The principal ...

Mutation in the Gene for Bone Morphogenetic Protein Receptor II as a Cause of Primary Pulmonary Hypertension in a Large Kindred Original Article, N Engl J Med 2001:345;319-324.. On page 321, Figure 1 should have shown the 87-year-old man in generation III ...

Bosentan Therapy for Pulmonary Arterial Hypertension Original Article, N Engl J Med 2002:346;896-903.. On page 896, the dose in the fifth line of the Methods section of the Abstract should have read, “62.5 mg of bosentan twice daily for 4 weeks,” not “...