Over the past 20 years, much has been learned about screening for colon cancer from biologic, epidemiologic, and clinical studies.¹ Colorectal cancer is a leading cause of death in the Western world, but survival can be improved if the disease is detected ...

The report in this issue of the Journal on the effect of copper intrauterine contraceptive devices on the risk of infertility in nulliparous women deserves the attention of American women and their clinicians.¹ Despite the efficacy of the intrauterine ...

The acute respiratory distress syndrome is a devastating, often fatal inflammatory condition that probably affects more than a million patients throughout the world each year.¹ Since its description over 30 years ago,² this syndrome has claimed the ...

In my recent book on the cardiovascular physical examination, Braunwald wrote, “Intelligent selection of investigative procedures from the ever-increasing array of tests now available requires far more sophisticated decision-making than was necessary when ...

To the Editor: At the beginning of his article on brain death (April 19 issue),¹ Dr. Wijdicks states, “Physicians, health care workers, members of the clergy, and laypeople throughout the world have accepted fully that a person is dead when his or her ...

To the Editor: The remarkable effects of the tyrosine kinase inhibitor STI571 in chronic myeloid leukemia and acute lymphoblastic leukemia reported by Druker et al. (April 5 issue)¹,² are frequently associated with adverse cutaneous reactions. The rash ...

To the Editor: The article on temporal aspects of heparin-induced thrombocytopenia (April 26 issue)¹ lacks some information that would be helpful. In particular, there is no mention of the type of heparin used in the initial treatment. In addition, the ...

To the Editor: In his review article on atrial fibrillation (April 5 issue),¹ Falk suggests that patients admitted to the hospital with atrial fibrillation of less than 48 hours' duration should be treated differently from those with atrial fibrillation ...

To the Editor: A 57-year-old man presented with an ulcerative, acral–lentiginous lesion on the sole of the left foot. Pathological examination showed a melanoma (Breslow depth, 2.2 mm; Clark level IV) without involvement of the surgical margins; the ...

To the Editor: High-molecular-weight hydroxyethyl starches (hetastarches) can cause acquired type I von Willebrand's disease.¹ A case has also occurred after treatment with medium-molecular-weight hydroxyethyl starches (pentastarches).² We analyzed all ...

When I first looked at the title of this book, I was both pleased and relieved. Pleased that an attempt had been made to consolidate the concepts of pulmonary immunotoxicology. Relieved that now I could turn or refer others to a single source of ...

There are at least four large, comprehensive textbooks on lung disease in children. Primary Pediatric Pulmonology is more a handbook of pediatric lung disease and focuses on evaluation and treatment of common disorders. Thus, the book is unique in concept,...

In 1992, Patrick edited a comprehensive textbook (Infections in Immunocompromised Infants and Children, Philadelphia, Churchill Livingstone). It contained a wealth of information in 56 chapters, spread over 850 pages. Clinical Management of Infections in ...

Gene-Expression Profiles in Hereditary Breast Cancer Correspondence, N Engl J Med 2001:344;2028-2029.. On page 2029, the sentence that begins on line 33 of the right-hand column should have read, “We first used three methods to derive lists of genes: ...