Oral contraceptives were not protective in carriers of a mutant BRCA1 or BRCA2 gene.

A genetically engineered molecule to treat resistant hairy-cell leukemia.

Psoriasis is a skin disorder that affects approximately 2 percent of the world's population.¹,² Although persons with mild psoriasis can often control the disease with topical agents, more than 1 million patients in the United States require ultraviolet ...

Infection with Burkholderia mallei (formerly Pseudomonas mallei) can cause a subcutaneous infection known as farcy or can disseminate to cause the condition known as glanders. In humans, acute infection with B. mallei is characterized by necrosis of the ...

Figure 1. A 27-year-old nulligravid woman presented with pelvic pain. Pelvic examination showed bilateral cystic, mobile, adnexal masses measuring 8 by 8 cm. A computed tomographic scan of the pelvis revealed bilateral adnexal masses with discrete, dense ...

Foreword

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's ...

Endometriosis is the growth of endometrium outside the uterine cavity or myometrium (endometriotic implants), usually in the peritoneal cavity (Figure 1). The question of how the tissue attains this abnormal placement is controversial, although the ...

Presentation of Case

An 18-month-old girl was admitted to the hospital because of diarrhea with intermittent constipation and vomiting.

The child had been born by cesarean section, performed because of a breech presentation, at 41 weeks' gestation; it was ...

The search for effective and specific antineoplastic therapy has led to considerable interest in antitumor antibodies. Attempts to treat cancer with antibodies date back to the early 1900s, but progress was stalled until discovery in 1975 of a way to ...

Psoriasis is an inflammatory skin disorder that affects about 1 to 3 percent of persons throughout the world.¹ Although most persons with plaque psoriasis have mild or moderate disease that affects small areas of the skin, some have extensive disease that ...

Glanders is a zoonotic disease of horses and related equids that was eliminated from the United States in 1934. The etiologic agent, Burkholderia mallei, has occasionally caused severe infection in humans after the transmission of small aerosolized ...

To the Editor: Turpie et al. (March 1 issue)¹ report the findings of a rigorously performed double-blind, randomized trial comparing a synthetic pentasaccharide (Org31540/SR90107A) and a low-molecular-weight heparin (enoxaparin) in patients undergoing ...

To the Editor: The clinical importance of rapidly achieving a therapeutic activated partial-thromboplastin time with respect to the treatment of venous thromboembolism with unfractionated heparin has been underscored in various studies¹ and reviews.² ...

To the Editor: Cardiac output is determined by heart rate and stroke volume. Since the latter is reduced in patients with ventricular systolic dysfunction, the cardiovascular reserve during exercise in patients with heart failure depends heavily on the ...

To the Editor: Hemingway et al. (March 1 issue)¹ conclude that, according to criteria set by an expert panel, coronary revascularization procedures are underused; patients who should have undergone a surgical intervention were incorrectly treated ...

To the Editor: In their excellent review article on cutaneous squamous-cell cancers (March 29 issue),¹ Alam and Ratner mention sunscreen use but not the prevention of these cancers in certain populations of patients at high risk. Among recipients of ...

To the Editor: Sterile ascites after ventriculoperitoneal shunting is rare and usually of unknown cause.¹ We describe a patient in whom an inflammatory reaction to silicone tubing used in the creation of a shunt was a possible cause of sterile ascites.

A ...

Two international, multivolume, multiauthored textbooks of psychiatry appeared almost simultaneously at the start of the millennium: the two volumes of the New Oxford Textbook of Psychiatry, derived mostly from Anglo-American sources, and the three ...

In Out of Its Mind: Psychiatry in Crisis, Hobson, a psychiatrist and neurophysiologist, and Leonard, a freelance science writer, have created the equivalent of a medieval triptych depicting hell, purgatory, and heaven. As in all such paintings, hell is ...

This book is a compilation of contributions to the 1999 American Psychopathological Association meeting on depression. A distinguished cast of researchers from the United States and Europe provides an authoritative overview of the history and empirical ...

Anxiety at the Frontier of Molecular Medicine Clinical Implications of Basic Research, N Engl J Med 2001:344;1247-1249.. On page 1248, in Figure 1, the GABA-binding site should span the alpha and beta subunits, not the beta and gamma subunits, as printed.

Is the Placebo Powerless? An Analysis of Clinical Trials Comparing Placebo with No Treatment Special Article, N Engl J Med 2001:344;1594-1602.. In the Web-only Supplementary Appendix 3, the point estimates for Hall et al. (1974) and Davidson et al. (1980) ...

Britain's National Health Service (NHS), as constituted in 1948, had two defining characteristics. First, it was a universal system, funded predominantly by taxation, that made health care available to the whole population and removed financial barriers ...