This investigation strengthens the case for mastectomy in women with a mutation of the BRCA1 or BRCA2 gene.

Extending oral anticoagulant therapy to 12 months is beneficial.

Drug resistance has become a major problem in the treatment of tuberculosis.¹ Resistance rates in Turkey are high because treatment approaches are often inappropriate, rates of treatment completion are low, and therapy is not directly observed. Despite a ...

Aquaporin-1, the archetypal water-channel protein,¹ was initially identified in red cells and renal proximal tubular epithelium.² The gene for aquaporin-1 (AQP1) on chromosome 7 colocalizes with the Colton blood-group antigen,³,⁴ and the Colton blood-...

Figure 1. A 72-year-old woman had a six-month history of upper abdominal swelling, pain in the right upper quadrant, weight loss of 13.6 kg (30 lb), anorexia, and generalized weakness. Laboratory analysis revealed an alkaline phosphatase level of 259 U ...

The volume of procedures was positively associated with survival.

In the 1980s, after decades of steadily declining rates of tuberculosis, ambitious plans were made to eliminate the disease in the United States. Despite these plans, the control of tuberculosis was neglected, resulting in a resurgence of the disease.¹ ...

Presentation of Case

A 25-year-old woman was admitted to the hospital because of persistent fever.

The patient was a resident of the Philippines who had flown to the United States 11 days before admission and spent 6 days in California. Seven days before ...

Genetic testing for susceptibility to breast cancer has been controversial since its inception. Among other issues, it has provoked questions about the efficacy and acceptability of prophylactic mastectomy for women with mutant BRCA1 or BRCA2 genes. These ...

In this issue of the Journal, Tahaoğlu and coworkers report on their experience in treating a cohort of patients infected with strains of Mycobacterium tuberculosis that are resistant to powerful antituberculosis drugs. Tuberculosis caused by strains that ...

Approximately 3 million Americans are thought to be infected with hepatitis C virus (HCV).¹ HCV causes chronic infection in about 85 percent of infected persons, and cirrhosis may develop in as many as 20 percent of those with chronic infection.² HCV ...

It is currently estimated that between 2.7 million and 4.0 million persons in the United States have chronic hepatitis C virus (HCV) infection.¹ Many of these persons have potentially progressive disease. Studies suggest that mortality and health care ...

To the Editor: Bernard and coworkers (March 8 issue)¹ conclude that recombinant human activated protein C (drotrecogin alfa [activated]) is efficacious in patients with sepsis. The placebo and treatment groups appeared to be closely matched, with one ...

To the Editor: In their review article on renal-artery stenosis (Feb. 8 issue),¹ Safian and Textor indicate that the results of surgery and interventional radiology are better for hypertension associated with fibromuscular hyperplasia than for ...

To the Editor: Hines et al. (Feb. 22 issue)¹ report that a polymorphism of the gene encoding alcohol dehydrogenase (ADH) — namely, the slow-oxidizing allele of the ADH3 gene — in male patients who consumed moderate amounts of alcohol significantly ...

To the Editor: Like prior case–control studies, a follow-up study from Sweden (March 15 issue)¹ reported that appendectomy is associated with a low risk of subsequent ulcerative colitis. These findings have led to speculation about causality, suggestions ...

To the Editor: We summarize cases of myocarditis and cardiomyopathy reported to the Food and Drug Administration (FDA) in patients treated with the atypical antipsychotic medication clozapine. Because it carries risks of agranulocytosis and seizures, ...

To the Editor: A 23-year-old woman with Langerhans'-cell histiocytosis presented with severe pain in the right iliac crest and right shoulder of three months' duration. The patient had undergone excision and radiation of a skeletal lesion of the left hip ...

Some drugs have become household names — penicillin, insulin, aspirin. Most are known — indeed, revered — as lifesavers. Thalidomide, too, falls into the category of well-known drugs, but for an entirely different reason. As a medicine that maimed rather ...

Educating for Professionalism: Creating a Culture of Humanism in Medical Education presents a candid and sometimes painful look at the culture of undergraduate medical education. “We are learning when you least expect it,” says an anonymous medical ...

Twenty percent of Americans live outside metropolitan areas in what is collectively called rural America. But rural America is no more homogeneous than the metropolitan areas of Manhattan, Kansas, and Manhattan, New York. Rural America can be ...

A Comparison of Nefazodone, the Cognitive Behavioral-Analysis System of Psychotherapy, and Their Combination for the Treatment of Chronic Depression Original Article, N Engl J Med 2000:342;1462-1470.. On page 1464, the definition of response and remission ...

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome Original Article, N Engl J Med 2001:344;1038-1042.. On page 1041, in Figure 2,...