The use of oral contraceptives first became widespread some 40 years ago, and reports of an excess risk of cardiovascular disease among women who used these agents soon followed. Because the risks seemed to be dose related, manufacturers created new ...

Despite the very large number of volunteers willing to donate bone marrow for unrelated recipients (currently numbering over 7 million worldwide), many candidate recipients still cannot obtain marrow because no HLA-matched volunteer can be found. The ...

“Take two aspirin and call me in the morning”? Clinical decision making is no longer so straightforward. Millions of patients take analgesic and antiinflammatory medications regularly. The reasons are simple: these drugs are effective in relieving pain ...

In this issue of the Journal, Lavie points out the high frequency of sleep disturbances, primarily insomnia and nightmares, that occur after local or distant disasters.¹ This observation is supported by the recent article on stress reactions after the ...

To the Editor: Lieberman et al. (Aug. 23 issue)¹ report that one-time screening with both a fecal occult-blood test and sigmoidoscopy failed to identify 24 percent of subjects with advanced neoplasia. They do not, however, comment on the incremental risk ...

To the Editor: Agnelli et al. (July 19 issue)¹ report the results of one of the few large trials addressing the optimal duration of anticoagulant therapy after a first episode of idiopathic deep-vein thrombosis. They state that improving risk ...

To the Editor: For a study that was conducted at 22 centers in the United States and that involved patients with a disease that has a worldwide prevalence of 2 percent, the recruitment of only 229 patients with psoriasis, as reported by Ellis and Krueger ...

To the Editor: In his review of subclinical hypothyroidism, Cooper (July 26 issue)¹ did not fully address the complex issue of prenatal screening. Since Haddow et al.² reported that the offspring of women with elevated thyrotropin concentrations had ...

To the Editor: Recent studies¹–³ have suggested that cyclooxygenase-2 (COX-2) inhibitors can be safely used in patients with asthma who have documented intolerance to COX-1 inhibitors such as aspirin and nonsteroidal antiinflammatory drugs. On the basis ...

Counters and classifiers of deaths and diseases, including demographers and epidemiologists, have long been fascinated with the statistical regularities of social inequalities in morbidity and mortality. The earliest studies of social class and mortality ...

Richard Rapport, a neurosurgeon, has written a fascinating and accurate account of the life of Paul Beeson, who rose to the highest levels of academic medicine not only because of his outstanding professional achievements but also because of his humility, ...

A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status EpilepticusOriginal Article, N Engl J Med 2001:345;631-637.. On page 637, the sentence that begins on line 14 of the left-hand column should have read, “We ...

Severe Coagulopathy as a Consequence of Smoking Crack Cocaine Laced with RodenticideCorrespondence, N Engl J Med 2001:345;700-701.. On page 701, in Table 1, the first entry in the first column should be “coagulation factor II,” not “coagulation factor I,” ...