How much does mind matter in the outcome of cancer? The extent to which treatment of the emotional aspects of cancer affects disease progression is ultimately an empirical question. There are those who believe that controlling cancer requires a simple ...

Meningitis remains a formidable foe because it often progresses rapidly and causes substantial morbidity and mortality.¹–³ The rational management of meningitis has generally included a lumbar puncture to substantiate the diagnosis and help identify the ...

Treatment for alcohol dependence has been limited almost entirely to various types of counseling. An exception has been the use of the medication disulfiram, which acts indirectly by making a person feel ill if he or she drinks alcohol. The efficacy of ...

The mitochondrion of the insulin-secreting pancreatic islet cell is a biochemical beehive in which the products of glucose oxidation influence the secretion of insulin. Work with cultured islets has shown that a mitochondrial ion carrier termed uncoupling protein 2 (UCP2 ) affects glucose-stimulated insulin levels. A recent report demonstrated that in mice with a disabled UCP-2 gene, insulin secretion was enhanced and blood levels of glucose were reduced. When the gene was knocked out in ob/ob mice, which are obese, insulin-resistant, and diabetic, insulin secretion increased and the hyperglycemia was ameliorated.

To the Editor: In the August 9 issue, Faust et al.¹ reported that the level of endothelial expression of thrombomodulin and the endothelial protein C receptor was lower in patients with meningococcal sepsis than in control subjects. This finding has ...

To the Editor: The study by deVeber and colleagues (Aug. 9 issue),¹ which reported 12 deaths among 160 children with cerebral sinovenous thrombosis, raises important issues about the future treatment of such patients, since only 1 of the children ...

To the Editor: Although the article by Hyman and Pavlik (Aug. 16 issue)¹ provides important insights into the control of hypertension, the results of some of the analyses may be misleading. In the analysis of predictors of lack of awareness, people ...

To the Editor: Vladeck¹ and Wilensky² (Aug. 9 issue) present alternative views regarding restructuring the Medicare program. Although the issues they discuss are critical, more attention should be paid to the fact that Medicare has become a program for ...

To the Editor: A small but growing number of patients with human immunodeficiency virus (HIV) infection undergo orthotopic liver transplantation for complications of intercurrent infection with hepatitis B virus (HBV), hepatitis C virus (HCV), or both. ...

According to the latest World Health Organization figures, 24 million people have schizophrenia, a disorder that is often serious, disabling, and relapsing. Perplexing yet intriguing, it beckons experts of an authorial bent to provide enlightenment and ...

Age-related loss of memory and other cognitive abilities has been recognized since antiquity. However, the need to understand the causes and consequences of dementia has become urgent over the past quarter-century because of the large and increasing ...

During the past few years, a number of books have been published examining the psychiatric issues related to epilepsy. These issues appear to be a respectable subject again in neurologic circles, in part because a new generation of neurologists and ...

Human Infection Due to Recombinant Vaccinia–Rabies Glycoprotein Virus Original Article, N Engl J Med 2001:345;582-586.. On page 583, in the legend to Figure 2, the magnification should have read, “×42,600,” not “×600,” as printed. We regret the error.

Case Records of the Massachusetts General Hospital (Case 29-2001) Case Records of the Massachusetts General Hospital, N Engl J Med 2001:345;903-908.. On page 907, Figure 3 and Figure 4 are reversed. In addition, the legend to Figure 3 should not refer to ...