Most patients who die of cancer die because of metastatic disease, and therefore removal of the primary tumor in patients who already have evidence of metastasis seems illogical, at least in the absence of symptoms caused by the primary tumor. Many ...

“Equality between mental health coverage and other health coverage is an affordable and effective objective,” according to a 1999 report by the Surgeon General.¹ On the basis of this conclusion and because of the limited effect of the Mental Health Parity ...

To the Editor: Modan and colleagues (July 26 issue)¹ conclude that oral contraceptives do not protect against ovarian cancer in Israeli Jewish women carrying BRCA mutations. We have shown, in two studies of Jewish and non-Jewish women with BRCA mutations,...

To the Editor: The review of autoimmunity by Davidson and Diamond (Aug. 2 issue)¹ leaves many points open for debate. The field has never properly come to grips with the question of whether antibodies can damage or impair intact cells by binding to ...

To the Editor: The review article by FitzGerald and Patrono (Aug. 9 issue)¹ on the coxibs, selective inhibitors of cyclooxygenase-2 (COX-2), included a table listing pharmacokinetic and metabolic features as well as drug interactions. According to the ...

The medical mystery in the October 18 issue¹ involved a 78-year-old woman with hypertension and diabetes who was hospitalized with cellulitis of her left lower leg. Colicky right-flank pain associated with nausea and vomiting developed. Intravenous ...

To the Editor: The letter by Boyer et al. (Aug. 9 issue)¹ decrying the prevalence of “partisan” sites on illicit-drug use neglected to mention that theoretically objective government sites contain misinformation about drugs as well. For example, the ...

To the Editor: In this issue of the Journal, Flanigan et al.¹ report the results of a randomized trial conducted by the Southwest Oncology Group (SWOG), which compared interferon alone with nephrectomy followed by interferon for the treatment of ...

Neurologic disease complicating human immunodeficiency virus (HIV) infection is common. Clinically significant neurologic disease ultimately affects up to 60 percent of HIV-infected persons, and pathological evidence of nervous system involvement at ...

Severe Community Acquired Pneumonia is part of a series entitled “Perspectives on Critical Care Infectious Diseases.” The editor states that “the specific objective of this Series is to update therapeutic implications and discuss controversial topics in ...

Treatment of Chronic Hepatitis C in Active Drug Users Sounding Board, N Engl J Med 2001:345;215-217.. On page 215, the sentence that begins 14 lines from the bottom of the right-hand column should have read, “Ho and colleagues reported that 68 percent of ...

Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation Original Article, N Engl J Med 2001:345;494-502.. On page 494, at the end of the Results section of the abstract, the percentages of ...