This large trial shows the efficacy of a single, prophylactic dose of doxycycline to prevent Lyme disease.

In randomized, double-blind trials, there was no significant difference in the health-related quality of life.

Tissue remodeling is central to the pathogenesis of many chronic illnesses. In the vascular narrowing of atherosclerosis,¹ the proliferation of smooth-muscle cells and the synthesis of matrix lead to the formation of a neointima. The same events in the ...

Figure 1. A 14-year-old girl in whom Kawasaki's disease was diagnosed at the age of 2 years had a posterior myocardial infarction at the age of 3 years. When we saw her she had signs of mild mitral regurgitation but no symptoms. Transthoracic ...

Living in a disadvantaged neighborhood was associated with an increased incidence of coronary heart disease.

The term “high-altitude illness” is used to describe the cerebral and pulmonary syndromes that can develop in unacclimatized persons shortly after ascent to high altitude. Acute mountain sickness and high-altitude cerebral edema refer to the cerebral ...

Since its original description nearly 25 years ago,¹ Lyme disease has become recognized as an important infectious disease in the United States. The infection, which is caused by the tick-borne spirochete Borrelia burgdorferi, is now endemic in more than ...

Presentation of Case

A 31-year-old man was admitted to the hospital because of an apparent seizure and radiologic evidence of a cerebral lesion.

The patient had been in excellent health until five days earlier, when he felt weak, was briefly unable to ...

Recently, a panel of experts of the Infectious Diseases Society of America recommended that persons bitten by deer ticks (Ixodes scapularis) should not routinely receive antimicrobial chemoprophylaxis.¹ This recommendation was based on an assessment of ...

Walk the slums of Dhaka, in Bangladesh, or Accra, in Ghana, and it is not difficult to see how the urban environment of poor countries could be responsible for bad health. Walk north from Manhattan's museum district to Harlem, or east from London's ...

The research community and the public have been engaged in a reexamination of the ethics and responsible conduct of research involving human subjects for many years. Since the 1995 report of the Advisory Committee on Human Radiation Experiments,¹ concern ...

There has been considerable controversy about the ethics of clinical trials that are sponsored or conducted by groups in industrialized countries but carried out in developing countries.¹–⁸ The National Bioethics Advisory Commission, of which we serve as ...

To the Editor: In the September 28 issue of the Journal, Saltz et al.¹ reported the superiority of the chemotherapy combination of irinotecan, fluorouracil, and leucovorin over irinotecan alone or fluorouracil and leucovorin in the initial treatment of ...

To the Editor: The study of the transplantation of embryonic dopamine neurons for severe Parkinson's disease reported by Freed et al. (March 8 issue)¹ revealed no benefit as measured on the basis of the primary outcome variable. In addition, severe ...

To the Editor: Hamano and colleagues (March 8 issue)¹ described 20 patients with sclerosing pancreatitis and demonstrated that they had elevated serum IgG4 concentrations. Additional clinical information is needed. Did any of the patients have histologic ...

To the Editor: McJunkin et al. (March 15 issue)¹ report that in patients with La Crosse encephalitis who have clinical deterioration, it follows the development of hyponatremia. This observation underscores the danger of administering hypotonic ...

To the Editor: Esplin and colleagues (March 22 issue)¹ found evidence of both paternal and maternal components of the predisposition to preeclampsia. However, their methods raise some issues of concern. First, this association was adjusted for 15 ...

To the Editor: Lyme disease and human granulocyte ehrlichiosis are infections carried by the deer tick, Ixodes scapularis. Ticks may harbor both Borrelia burgdorferi and the human granulocytic ehrlichiosis bacterium, the causative agents of these ...

In the past three decades, we have seen exponential growth in the number of opportunities for women athletes, outpaced only by gains in the numbers and performances of the participants themselves. Women in Sport is a monumental work of art that presents ...

Epithelial ovarian cancer, the second most common cancer of the female genital tract, accounts for 5 percent of cancers in women. In the United States this year, 23,400 new cases will be diagnosed, and 13,900 women afflicted with the disease will die. The ...

The purpose of this book is to provide a single resource for physicians caring for women with infection. Conceived and written by leaders in the field of obstetrical and gynecologic infections, Infectious Diseases in Women will serve students, residents, ...