On the basis of evidence from multiple clinical trials, it is recommended that antihypertensive therapy be instituted for patients with confirmed hypertension — that is, when the systolic blood pressure exceeds 140 mm Hg or the diastolic blood pressure ...

For decades, if a patient required a parenteral anticoagulant agent, the choice was simple: unfractionated heparin was the only such agent available. Unfractionated heparin has a long track record of effectiveness in both the treatment of and prophylaxis ...

In this issue of the Journal, Ferris et al.¹ report on the experience of Harvard Vanguard Medical Associates, a multispecialty prepaid group practice, after it eliminated a gatekeeping system that had been in place for more than 25 years. During the first ...

The thought-provoking article by Zinkernagel in this issue of the Journal ¹ brings to a close the series of review articles on immunology that have been appearing in these pages during the past 17 months. Those who have read these reviews will conclude ...

One hundred years ago, type 2 diabetes mellitus was considered a rare disease, but recently there has been an explosive increase in its incidence. About 16 million Americans have type 2 diabetes,¹ and at least an equal number have impaired glucose ...

To the Editor: The report by Nadelman et al. (July 12 issue)¹ suggests that a single dose of doxycycline given within 72 hours after an Ixodes scapularis tick bite is effective in the prevention of early Lyme disease. Should the results of this study ...

To the Editor: The superb review article on Lyme disease by Steere (July 12 issue)¹ omitted a manifestation associated with the disease: ocular Lyme borreliosis. Ocular Lyme borreliosis is probably underdiagnosed not only because of difficulties in the ...

To the Editor: In their Clinical Practice article (June 14 issue), Lee and Boucher review the use of noninvasive tests in patients with stable coronary artery disease.¹ However, the authors do not comment on electron-beam computed tomography as a ...

To the Editor: The early deaths reported by Sargent et al. (July 12 issue)¹ among patients with colorectal cancer who were enrolled in trials N9741 and C89803 have aroused concern regarding the use of irinotecan in combination with fluorouracil and ...

To the Editor: Hepatic-artery thrombosis early after liver transplantation is associated with a very high rate of graft loss and death.¹ If urgent revascularization fails² or if massive hepatic necrosis has already developed, prompt retransplantation is ...

For most of the 20th century, the rate of death from breast cancer in the United States has remained stable, with a moderate decline occurring only in the past few years. In The Breast Cancer Wars, Barron Lerner, a physician and historian of medicine, ...

This book is a masterly review of the field of renal transplantation, edited by Sir Peter Morris, a universally esteemed pioneer who has devoted his life to the clinical and immunologic aspects of renal transplantation. The previous four editions, ...

A Magic Bullet for Cancer — How Near and How Far? Editorial, N Engl J Med 2001:345;283-284.. On page 283, the sentence that begins 22 lines from the bottom of the left-hand column should have read, “The resulting humanized chimeric monoclonal antibodies ...