Antimicrobials have been used in food animals in North America and Europe for nearly half a century. Among the most common are drugs that are either identical to or related to those administered to humans, including penicillins, tetracyclines, ...

In 1972, the first biochemical abnormality to be identified in a form of the Ehlers–Danlos syndrome, a deficiency of lysyl hydroxylase, a collagen-modifying enzyme, was described in the Journal.¹ Many other forms of the syndrome have since been ...

The genomic sequences of more than 30 bacterial species, including virtually all important human pathogens, have been deciphered. The pneumococcus, discovered in 1880 virtually simultaneously by Pasteur in France and Sternberg in the United States and ...

To the Editor: Ridker and colleagues (June 28 issue)¹ demonstrated that the rate of acute coronary events among subjects with a base-line low-density lipoprotein (LDL) cholesterol level below 149.1 mg per deciliter and a C-reactive protein level above ...

To the Editor: Green et al. (June 28 issue)¹ may have severely underestimated how the changes in medicine and society have affected emergency medicine. In their reanalysis of the monthly prevalence of illness in the community and the roles of various ...

To the Editor: Rogan et al. (May 10 issue)¹ conclude that chelation therapy with succimer for children with lead levels of 20 to 44 μg per deciliter is valueless. However, an important methodologic weakness of their study is that succimer therapy failed ...

To the Editor: PC-SPES is a commercially available nutritional supplement containing eight herbs that is used by many patients with prostate cancer. It has potent estrogenic activity and substantial antineoplastic effects in patients with prostate ...

To the Editor: A 63-year-old man with a dense left hemiplegia from a stroke two and a half years earlier was seen in the clinic in May 2000 with clinical evidence of relapsed malignant melanoma of the scalp. Stage II malignant melanoma over the vertex ...

Adrenal Disorders reflects developments in the understanding of adrenal physiology that have gathered momentum in the past 10 years and parallel major advances in molecular biology. The book includes new insights into a number of clinical conditions, ...

The use of imaging technology in the investigation of disorders of the head and neck has increased awareness of nodular thyroid disease in all areas of medicine. But are there enough important unanswered questions about thyroid cancer and has there been ...

One of the highlights among the remarkable achievements in medicine over the past four decades has been the development of antihypertensive agents. Since the introduction of these agents into clinical practice, cardiovascular mortality in this country has ...