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October 4, 2001  Vol. 345 No. 14

Original Articles
1007-1013

A previously unrecognized clone of E. coli appears to be involved in many of the community-acquired urinary tract infections in three locations in the United States.

1014-1021

There may be neurohormonal activation in patients at high risk for death.

1022-1029

PAPP-A, a marker of Down's syndrome, may also be a useful marker of unstable coronary-artery plaques.

1030-1035

In humans, the β2-adrenergic receptor mediates physiologic responses, including vasodilatation, bronchial smooth-muscle relaxation, and lipolysis, in various tissues.1 Altered mediation of vascular responses by this receptor may play a part in the ...

1036-1040

Type 1 diabetes results from an immune-mediated destruction of pancreatic beta cells. The disease can be transmitted by bone marrow transplantation in humans1 and animals.2,3 Furthermore, T cells that are reactive to several islet autoantigens have been ...

Images in Clinical Medicine
1041
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Figure 1. An 18-year-old woman (gravida 0, para 0) presented with a six-month history of abdominal distention but no history of weight loss or abnormality in menstruation. Radiography showed an abdominal mass with a ground-glass appearance and ...

e3
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A 46-year-old fisherman presented with a recurrent rash. For two years his skin had been prone to blister and tear with minor trauma. At times his urine appeared to contain blood.

Review Article
1042-1053

More than 70 bacteria, viruses, parasites, and fungi are serious human pathogens.1 Vaccines are available against some of these agents and are being developed against almost all the other bacteria and viruses and about half of the parasites. Table 1 lists ...

Editorials
1055-1057

Community-acquired urinary tract infections occur mostly in women, are generally caused by Escherichia coli, and are among the most common bacterial infections. For the past two decades, trimethoprim–sulfamethoxazole or trimethoprim alone has been used ...

1057-1059

The acute coronary syndromes, which comprise unstable angina, myocardial infarction without ST-segment elevation, and myocardial infarction with ST-segment elevation, continue to be a major health problem. Recent important advances in revascularization ...

Clinical Implications of Basic Research
1060-1061

In this issue of the Journal, Martin et al.1 present a striking report of a boy with X-linked agammaglobulinemia in whom typical type 1 insulin-dependent diabetes mellitus developed at the age of 14 years. This report is of great interest because it shows ...

Correspondence
1063-1064

To the Editor: Accurate identification of phenotype is critical for precise genetic characterization. Standard textbooks define the Wolff–Parkinson–White syndrome as the combination of a short PR interval, an increased duration of the QRS complex caused ...

1064-1065

To the Editor: Istre et al. (June 21 issue)1 reported that 5.5 percent of house fires were caused directly by smoking and 4.5 percent by children playing with fire, which is greatly facilitated by the presence of smoking paraphernalia, such as matches ...

1065-1066

To the Editor: A prior report from an Eastern Cooperative Oncology Group trial of adjuvant therapy (EST 2284), one of the trials that provided samples for the study by Watanabe et al. (April 19 issue),1 showed that there is a statistically significant ...

1066-1067
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To the Editor: In their review, Mannucci and Tuddenham (June 7 issue)1 discuss the use of recombinant clotting factors for the treatment of hemophilia. When these products were introduced, it was anticipated that there would be an inexhaustible supply of ...

1067-1068

To the Editor: Intracytoplasmic injection of sperm is the recommended treatment for male infertility, associated with an average pregnancy rate per cycle of about 30 percent.1 Although sperm count and motility were found to have no effect on the outcome ...

1068-1069

To the Editor: The addition of egg to the paste used to protect stone buildings is an old custom, with origins in ancient Rome.1,2 We describe a patient who had an episode of severe asthma and atopic dermatitis caused by the release of this hidden ...

Book Reviews
1070

In the past half century, new genetic, biochemical, neuropathological, neurocognitive, and neuroimaging methods have led to a better understanding of brain disease and have allowed us to distinguish such disease from the aging of a healthy brain. ...

1070-1071
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Cerebral vasospasm is a delayed, severe clinical event after an aneurysmal subarachnoid hemorrhage. The vasospasm can affect all the cerebral arteries but principally affects the large arteries located around the ruptured aneurysm. At times the arterial ...

1071

Diagnosis and Management of Peripheral Nerve Disorders is the latest in the valuable Contemporary Neurology Series from Oxford University Press. Although multiple experts contributed to the book, the three editors helped to write all but 5 of its 31 ...

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