The prevalence of end-stage renal disease is increasing at an alarming rate. In 2000, chronic kidney failure developed in over 90,000 people in the United States; the current population of patients on dialysis numbers about 300,000, and 80,000 patients ...

The use of placebo-controlled trials began just before World War II, and the Declaration of Helsinki, which arose from the Nuremberg Code, was formulated after the war. Placebo-controlled studies soon became the gold standard of evidence, and the ...

The first placebo-controlled trial was probably conducted in 1931, when sanocrysin was compared with distilled water for the treatment of tuberculosis.¹ Ever since then, placebo-controlled trials have been controversial, especially when patients randomly ...

To the Editor: Dr. Grohskopf and her colleagues (May 17 issue)¹ and the editorialist who commented on their study of Serratia liquefaciens infections at a hemodialysis center² missed an opportunity to evaluate the errors in the system that contributed to ...

To the Editor: Cronin et al. (May 24 issue)¹ suggest that there has been a lack of oversight in the evolution of liver transplantation involving living donors. They overlook recent reports and conferences that show widespread concern for living organ ...

To the Editor: Gao et al. (May 31 issue)¹ report the identification of specific HLA-B*35-Px subtypes as responsible for the association between HLA-B*35 and rapid progression to AIDS, and they stress the importance of homozygosity for HLA-B*35 as a ...

To the Editor: Angiotensin-converting–enzyme (ACE) inhibitors have been shown to reduce proteinuria and slow the progression of renal disease.¹ Although to date angiotensin II has been the focus of attention as the primary mediator of the renin–...

To the Editor: Hereditary hemorrhagic telangiectasia is an autosomal dominant disease characterized by epistaxis, cutaneous telangiectases, and visceral arteriovenous malformations.¹ Aminocaproic acid, an antifibrinolytic drug, can reduce epistaxis in ...

This book is an up-to-date, comprehensive review of the latest research on sudden death from cardiac causes and of the optimal management for its prevention. Sudden death from cardiac causes is a serious public health problem, particularly in the ...

Preventive Cardiology covers the care of persons with risk factors for coronary disease. The editor is a major contributor to the field; all of her 27 coauthors are from the United States, and more than half are from the Cleveland Clinic. Their advice ...

Cardiovascular diseases, especially coronary heart disease and ischemic stroke, are the leading cause of morbidity and mortality in the Western world. Although the importance of primary and secondary prevention has been recognized, the decline in rates of ...