Uterine rupture is more likely in women who have a trial of labor.

Recombinant human α-galactosidase A replacement therapy may prevent disability and early death.

A gene encoding a neuronal calcium channel may be responsible for some cases.

Fabry's disease is an X-linked inborn error of glycosphingolipid catabolism caused by deficient activity of α-galactosidase A, a lysosomal exoglycosidase.¹,² In males with the classic form of the disease, there is little if any α-galactosidase A activity. ...

Figure 1. A 25-year-old man had a seven-month history of repeated, unprovoked, sudden vomiting without accompanying headache or any other neurologic or gastrointestinal symptoms. Vomiting had occurred daily in the previous two months. The results of a ...

Foreword

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' ...

Hepatitis C virus (HCV) infects an estimated 170 million persons worldwide and thus represents a viral pandemic, one that is five times as widespread as infection with the human immunodeficiency virus type 1 (HIV-1). The institution of blood-screening ...

Nearly 40 years ago, Douglas et al. documented the risk of uterine rupture during a trial of labor after cesarean section.¹ Among more than 2000 women with scars from prior cesarean sections, uterine rupture occurred during labor in just over 1 percent, ...

The treatment of a genetic disorder requires in-depth understanding of a biochemical aberration, clinical expertise in treating the target disease, and customized approaches to caring for individual patients. Recent advances in the treatment of Fabry's ...

Hemiplegic migraine (with or without cerebellar signs), spinocerebellar ataxia, and episodic ataxia can all result from changes in the gene that encodes the P/Q-type neuronal calcium channel, just one of the 35,000 or so genes that make up the human ...

Measles virus suppresses host immunity to tuberculosis, as may some types of live measles-virus vaccine.¹ Tuberculosis and measles remain important factors in childhood morbidity and mortality, particularly in the developing world. The life of Edward VI, ...

To the Editor: Our 1995 paper on the reconstitution of hematopoiesis after high-dose chemotherapy¹ has been the subject of an investigation by the German Research Council. Since we wish the published data to be beyond dispute, we hereby retract the ...

To the Editor: Högenauer and colleagues (Jan. 25 issue)¹ report on a patient with intermittent severe diarrhea and malabsorption, which lasted several months and “improved spontaneously.” There was no increase in serum cholecystokinin levels, and no ...

To the Editor: The study by Clifton et al. (Feb. 22 issue)¹ has two shortcomings. First, brain temperature was not monitored. Second, the types of injuries were neither described nor analyzed. Hypothermia might be beneficial in patients with specific ...

To the Editor: As a group, fat-soluble vitamins are lifesaving at physiologic levels and dangerous at megavitamin levels.¹ For many people the word “vitamin” implies something that is beneficial and essential, not potentially poisonous.² More than one ...

To the Editor: Chan et al. (March 29 issue)¹ sought to determine whether eradication of Helicobacter pylori is “equivalent to maintenance treatment with omeprazole” in the secondary prevention of upper gastrointestinal bleeding in patients taking low-...

To the Editor: The study by Freedberg et al. (March 15 issue)¹ compared a three-drug regimen with no antiretroviral therapy in patients infected with the human immunodeficiency virus (HIV) and found the regimen to be effective. One weakness of this study ...

To the Editor: The disposition of unused embryos is a pressing problem for in vitro fertilization programs.¹,² Although cryopreservation of embryos gives couples the chance to make additional attempts at pregnancy, unused frozen embryos create a storage ...

This book is the second in a Nutrition and Health series, planned as resources for physicians and nutritionists with a view to answering the questions of their patients and clients. The series highlights and reviews recent research and is said to be ...

It has been said that only 10 percent of medical illnesses can be attributed to specific diseases; even patients with cancer vary greatly in their responses to it. According to the traditional biomedical concept of disease, the functional gastrointestinal ...

This book, the second edition of Current Management of Inflammatory Bowel Disease, first published in 1989, is devoted to the medical, surgical, and supportive treatment of patients with Crohn's disease and ulcerative colitis. It includes chapters on 138 ...