Pneumocystis carinii pneumonia was a common and often fatal infection in patients infected with the human immunodeficiency virus (HIV) in the early 1980s.¹ Before the use of primary prophylaxis became standard, the proportion of patients with P. carinii ...

The life expectancy of patients with human immunodeficiency virus (HIV) infection has dramatically improved,¹–⁴ and the risk of opportunistic infections, including Pneumocystis carinii pneumonia, has markedly declined in industrialized countries since ...

Hematopoietic cells reside predominantly in the bone marrow but can be mobilized in large numbers in the blood by the administration of filgrastim (recombinant granulocyte colony-stimulating factor [G-CSF]). Apheresis products containing G-CSF–mobilized ...

Mucopolysaccharidosis I is a lysosomal storage disease caused by a deficiency of α-L-iduronidase, an enzyme that cleaves the terminal α-l-idu-ronic acid residues in the glycosaminoglycans heparan sulfate and dermatan sulfate.¹,² The deficiency blocks the ...

Salmonella enterica serotype typhimurium is the most common salmonella serotype isolated from humans and animals in the United States. From 1994 to 1998, this serotype made up 24 percent of salmonella isolates from humans and 19 percent of isolates from ...

Figure 1. Severe tricuspid regurgitation developed in a 32-year-old man after he had undergone repair of tetralogy of Fallot. After the tricuspid valve was replaced with a Carpentier–Edwards bioprosthetic valve, critical tricuspid stenosis developed that ...

There is a wide consensus that managed care has substantially reduced the length of patients' office visits with physicians.¹–⁹ Kenneth Ludmerer, for example, expresses this view:

Perhaps the most extraordinary development in medical practice during the ...

Acute pharyngitis is one of the most common illnesses for which patients visit primary care physicians. According to the National Ambulatory Medical Care Survey, upper respiratory tract infections, including acute pharyngitis, are responsible for 200 ...

Presentation of Case

A 42-year-old woman was admitted to another hospital because of worsening dyspnea and cough.

During the year before admission, the patient had had mild dyspnea on exertion, a cough that was occasionally productive of whitish mucus, ...

Until the widespread adoption of specific prophylaxis in the late 1980s, Pneumocystis carinii pneumonia was among the most common life-threatening opportunistic infections associated with infection with the human immunodeficiency virus (HIV) in ...

Many physicians today believe that they are not able to spend as much time with patients as they did in the past. They blame our confused health care system and are concerned about not having enough time to address the many needs of their patients. In ...

To the Editor: In their prospective study of patients with asymptomatic aortic stenosis, Rosenhek et al. (Aug. 31 issue)¹ note that the rate of progression of aortic-jet velocity was significantly higher in patients who underwent aortic-valve replacement ...

To the Editor: Jacobs et al. (Sept. 28 issue)¹ suggest that interferon beta-1a therapy for some patients with a first clinically isolated syndrome of multiple sclerosis may delay the onset of clinically definite multiple sclerosis. The diagnosis of ...

To the Editor: As Olin points out in his review (Sept. 21 issue),¹ exposure to tobacco plays a central part in the initiation and progression of thromboangiitis obliterans (Buerger's disease). However, the cause of Buerger's disease remains unknown. Not ...

To the Editor: The excellent review by von Andrian and Mackay (Oct. 5 issue)¹ outlines the challenges faced by the lymphoid system when it responds to a diverse array of pathogens. In their introduction the authors restate a common misconception about ...

To the Editor: We used wireless-capsule endoscopy¹ to assess patients with obscure or uncontrolled gastrointestinal bleeding. The capsule endoscope contains a miniature video camera, a light source, batteries, and a radio transmitter (Figure 1). Video ...

To the Editor: Recently there have been reports of unexplained sepsis and deaths among intravenous drug abusers in Scotland, Ireland, and England.¹ Approximately one quarter of these cases have been associated with clostridium species, of which half were ...

Inborn Metabolic Diseases, edited by Fernandes et al., is a pleasure to read. This book, “written by clinicians for clinicians,” is in its third edition and seems to have come of age. It is a cohesive and authoritative work covering the fast-growing field ...

Forty years ago it made sense to link obstetrics with gynecology because both dealt exclusively with the care of women, pregnant or not. In the 1960s, research began to focus on the hitherto unexplored world of the developing fetus, and the technological ...

As pediatric cardiology continues to evolve, the updating of older textbooks and the publication of new ones require keeping up with advances in surgical, diagnostic, and interventional (catheter-based) procedures. Rapidly expanding knowledge of normal ...

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis Original Article, N Engl J Med 2000:343;1586-1593.. On page 1592, on lines 15 and 16 of the Appendix, it should have been stated that M. Miller is from Portland, Maine,...

Hyperparathyroid and Hypoparathyroid Disorders Review Article, N Engl J Med 2000:343;1863-1875.. On page 1865, in Figure 2, the domain on the lower left-hand side of the figure should have been labeled “Primary hypoparathyroidism,” not “Primary ...