Treatment with lovastatin reduced the risk of coronary events.

There were no differences in the rate of survival or neurosensory impairment at 18 months.

From 1963 to 1999, 11 percent of the 93 infected patients died.

Human immunodeficiency virus type 1 (HIV-1)–associated nephropathy is the chief cause of chronic renal disease in patients with HIV-1 infection and is now the third leading cause of end-stage renal disease in blacks 20 to 64 years of age.¹,² These ...

Figure 1. A 69-year-old woman with a permanent pacemaker became nauseated at a luncheon, vomited, and collapsed. Paramedics arrived within three minutes and found her pulseless, in ventricular fibrillation, and with agonal respirations. She was intubated; ...

The chief reason that patients are admitted to an intensive care unit is to receive ventilatory support. In this article, I update the basic principles of mechanical ventilation, which I reviewed in the Journal in 1994,¹ and discuss recent advances.

Basic ...

Women with primary invasive breast cancer receive both local and systemic treatment. Surgery and radiation therapy are local treatments given to reduce the risk of recurrent cancer in the breast, chest wall, and regional lymph nodes. In some cases, these ...

Presentation of Case

A 64-year-old man was admitted to the hospital because of fever and bacteremia.

The patient had had hypertension for 20 years, type 2 diabetes mellitus for 16 years, and coronary disease for 7 years, with a history of myocardial ...

C-reactive protein is the classic acute-phase reactant. During severe infection or inflammation, blood concentrations of C-reactive protein may increase by a factor of 500 or more. Although most other acute-phase reactants are not as dynamic or as easily ...

“Current discussions about medical care appear largely concerned with two questions: Is the burgeoning harvest of new knowledge fostered by immense public investment in medical research being delivered effectively to the consumers? Is the available ...

Since its publication in the Journal in 1961, “The Ecology of Medical Care,” by White et al.,¹ has provided a framework for thinking about the organization of health care, medical education, and research (Figure 1). This conceptualization, inspired in ...

To the Editor: Hilbert and coworkers (Feb. 15 issue)¹ report that immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure who were treated with noninvasive ventilation had a lower rate of endotracheal intubation, a ...

To the Editor: The sample set used by Hedenfalk et al. (Feb. 22 issue)¹ may not be representative of the natural distribution of the characteristics of tumors with BRCA1 mutations, tumors with BRCA2 mutations, and sporadic cases of breast cancer. The ...

To the Editor: Bravo et al. (Feb. 15 issue)¹ list hemostatic contraindications to percutaneous liver biopsy. A prolonged bleeding time (≥10 minutes), in our opinion, has not been proved to predict a risk of biopsy-related bleeding. The evidence that ...

To the Editor: The recent report of an astrocytoma following the pyramidal tract (Dec. 7 issue)¹ was quite interesting. We report on the use of fludeoxyglucose F18 positron-emission tomography (PET) in the evaluation of a patient with an astrocytoma.

The ...

All editors of medical journals are expendable. But the fall, when it comes, is frequently painful and unexpected. Not so for George Lundberg, editor-in-chief of the Journal of the American Medical Association (JAMA) for 17 years: he knew that his sacking ...

This book is an important contribution to the growing literature on health promotion and disease prevention. It successfully brings together the theoretical basis of health promotion and disease prevention and practical formulas for changing the behavior ...

Abuse of any kind is abhorrent, and abuse of elderly persons is one of the more shameful forms. Dr. Payne's slim book (188 pages of text) highlights this enormous problem.

Payne briefly discusses a broad range of abuse, including physical and emotional ...