An early invasive strategy is better than a conservative strategy, especially for higher-risk patients.

Tirofiban has less efficacy than abciximab in preventing ischemic events after stenting.

Coronary stenting and antiplatelet therapy both play an important part in interventional cardiology,¹–³ and the emergence and development of both therapies have been closely associated.⁴–⁷ The combination of ticlopidine and aspirin enhances the benefit of ...

This report demonstrates the power of predictive genetic screening in hereditary cancer syndromes.

Figure 1. Two months after an inferoposterior myocardial infarction, a 71-year-old woman presented to her physician with a one-week history of acutely worsening shortness of breath and exertional dyspnea. At the time of the initial event, a transthoracic ...

House fires remain an important cause of death and injury, accounting for more than 3000 deaths and 17,000 injuries each year in the United States.¹ Interventions such as programs for the distribution of smoke detectors to prevent injuries related to ...

Respiratory syncytial virus (RSV), originally recovered from a colony of chimpanzees with coryza and designated chimpanzee coryza agent,¹,² and human parainfluenza virus types 1, 2, 3, and 4 have been known primarily as respiratory pathogens in young ...

Presentation of Case

A 50-year-old man was admitted to the hospital because of fever and arthralgias.

The patient had been in excellent health until six weeks earlier, when a sore throat, rhinorrhea, headaches, and low-grade fever developed. Two weeks ...

During the past 10 years there has been a revolution in the management of acute coronary syndromes, which include unstable angina and non–Q-wave myocardial infarction, and reductions in the rate of adverse events after percutaneous coronary ...

The management of acute coronary syndromes has evolved rapidly over the past decade and continues to do so. Three studies on this topic appear in this issue of the Journal. They are the Treat Angina with Aggrastat and Determine Cost of Therapy with an ...

Dramatic advances in our understanding of the genetic basis of cancer have led to new forms of technology and new tools for assessing the genetic risk of cancer. In this issue of the Journal, Huntsman et al.¹ report the experience of two families with ...

To the Editor: Reichert et al. (March 22 issue)¹ compare excess mortality in Japan and the United States from 1949 through 1998. They conclude that vaccination of schoolchildren against influenza, the only independent variable assessed, reduced mortality ...

To the Editor: In Figure 1 of their important report on expenditures for the care of patients infected with the human immunodeficiency virus (HIV) (March 15 issue),¹ Bozzette et al. show the trends in average monthly spending for the care of HIV-infected ...

To the Editor: We were surprised that the diagnosis of pernicious anemia in Case 40-2000 (Dec. 28 issue)¹ was based only on a mean corpuscular volume of 104 μm³, the presence of atrophic gastritis, and a serum B₁₂ level of 115 pg per milliliter. For a ...

To the Editor: A recent Case Record (Feb. 15 issue)¹ highlighted the importance of considering celiac disease in an adult with iron deficiency. It is usual in Australia for a small-bowel biopsy to be performed in patients with iron deficiency, and had ...

To the Editor: Thalidomide is effective for the treatment of refractory myeloma.¹ Its role in the initial treatment of the disease is under active investigation.²,³ We report the occurrence of deep venous thrombosis with the use of thalidomide in ...

Transplantation has long been recognized as a value-laden enterprise. However, although there have been innumerable pieces on ethical issues in transplantation, there has been no systematic treatment of the subject. Robert Veatch's newest book seeks to ...

The importance of pathology and immunology in transplantation is increasing with the widespread use of organ and tissue transplantation for the treatment of end-stage diseases. Recently, the end points for clinical trials in organ transplantation have ...

Depurative therapy is life-sustaining for more than 300,000 patients with end-stage renal disease in the United States and for many others in whom acute renal failure develops during their hospital course. Yet the annual overall mortality in end-stage ...

Epilepsy Review Article, N Engl J Med 2001:344;1145-1151.. On page 1150, Table 3 does not include topiramate. The information for topiramate is given below.