The attack rate increased sharply with age, and seven patients died.

Umbilical-cord blood from unrelated donors can restore hematopoiesis in adults who receive myeloablative therapy.

Probable causative mutation was identified in a protein kinase gene (PRKAG2) on chromosome 7.

Failure of the transition to a cardiorespiratory circulation at birth results in persistent pulmonary hypertension of the newborn. Characterized by elevated pulmonary vascular resistance with extrapulmonary right-to-left shunting of blood across the ...

Figure 1. A male infant who had been delivered by elective cesarean section to a healthy 41-year-old woman at 38 weeks' gestation presented at 23 hours of age with increasing respiratory distress. Although well at birth, he began to have respiratory ...

Foreword

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' ...

In 1849, Cumming¹ said of the irritable bowel syndrome, “The bowels are at one time constipated, another lax, in the same person. How the disease has two such different symptoms I do not profess to explain.” Over the years, the unexplained ...

Presentation of Case

A 19-month-old boy was admitted to the hospital because of a febrile illness and refusal to walk.

The child's immunizations were up to date. His mother was Portuguese, and his father was Brazilian. Two months before admission, during ...

Molecular diagnostic techniques, including the amplification of viral nucleic acid from cerebrospinal fluid by the polymerase chain reaction (PCR), have revolutionized the diagnosis of viral infections of the central nervous system.¹ Nevertheless, the ...

Transplantation of umbilical-cord blood was successfully performed for the first time in 1988 to treat a boy with Fanconi's anemia; the donor, the boy's newborn sister, was a perfect HLA match for her brother.¹ Since then, the advantages of cord blood as ...

Since its initial description¹ seven decades ago, the Wolff–Parkinson–White syndrome has attracted cardiologists' attention not only because of its clinical importance but also because of the opportunity it provides to learn about electrical conduction in ...

To the Editor: The report by Murphy et al. (Feb. 22 issue)¹ is misleading in stating that vaccination with the tetravalent rhesus–human reassortant rotavirus vaccine (RRV-TV) was associated with an increased risk of intussusception. The data show only ...

To the Editor: Tsubono et al. (March 1 issue)¹ reported that the consumption of five or more cups of green tea per day was not associated with a decreased risk of gastric cancer in a prospective study in Japan. However, this study did not address a ...

To the Editor: I enjoyed the captopril-augmented renal scan in Images in Clinical Medicine (Feb. 8 issue).¹ The proposed approach, however, can result in unnecessary scanning. Unaugmented renal scanning has a false negative rate of 20 to 25 percent and ...

To the Editor: We disagree with Marik (March 1 issue)¹ about the bacteriology of aspiration pneumonia and his therapeutic recommendations. Marik contends that anaerobes are seldom involved in aspiration pneumonia, on the basis of both our results² and ...

To the Editor: Dr. Smith's addendum to the Case Record in the January 25 issue¹ contains a misleading and erroneous statement. The patient is described as being “legally blind in the right eye” while able to see with an acuity of 20/30 in the left eye. A ...

To the Editor: Despite promising outcomes in the transplantation into pediatric recipients of umbilical-cord blood from unrelated donors, the low cell dose adversely affects both the rate of hematopoietic recovery and the probability of survival.¹–³ The ...

This book summarizes the latest information on the diagnosis and treatment of patients with vascular dementia. The authors, experts in the field, wrote this updated edition for neurologists and others who care for our growing elderly population. Vascular ...

Reading this book was a pleasure. The three authors have a wealth of experience, and their book is uniformly high in quality, authoritative, cohesive, down to earth, and easy to read. It has none of the unevenness and missing or overlapping topics so ...

There is a vast difference between focal and generalized epilepsy, and even within these categories there are extensive differences in symptoms, causes, and treatments. Intractable Focal Epilepsy, the first book of its kind, deals with one major category ...

Longitudinal Assessment of Neurocognitive Function after Coronary-Artery Bypass Surgery Original Article, N Engl J Med 2001:344;395-402.. On page 397, in Table 1, the age of the patients who completed follow-up should have been 60.6±10.4, not 61.0±10.4, ...

Atrial Fibrillation Review Article, N Engl J Med 2001:344;1067-1078.. On page 1071, in Table 2, the maintenance dose for propafenone should have been, “150–300 mg every 8 hours,” not “150–300 mg twice daily,” as printed.