In some of the recipients, the plasma levels of factor VIII activity rose and bleeding diminished for up to 10 months.

Estrogen treatment led to decreases in serum free thyroxine concentrations and increases in serum thyrotropin concentrations.

Myocyte replication occurs in the failing human heart,¹ and this form of cell growth tends to compensate for the exhaustion of myocyte hypertrophy.² In chronic heart failure, myocytes at most double in size, and when this limit has been reached no further ...

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is a recessive disorder of early childhood.¹ Symptoms of the disease generally appear in infancy and include protracted diarrhea, ichthyosiform dermatitis, insulin-...

Figure 1. A 29-year-old man from northern Thailand had a three-week history of recurrent fever (a temperature of up to 40°C), generalized weakness, poor appetite, and weight loss. One week before hospitalization, papular skin lesions developed on his face ...

In 1981, no one would have believed that unusual infections in five young men were the harbinger of a worldwide health catastrophe.

Of the various types of hemophilia, the most common of these lifelong bleeding disorders are due to an inherited deficiency of factor VIII or factor IX (Table 1). The genes for these blood coagulation factors lie on the X chromosome, and when mutated, ...

In the fall of 1981, a patient was referred to one of us at a teaching hospital in Boston for the evaluation of hypoxemia and a mildly abnormal chest radiograph. It was perplexing that a previously healthy man, without known risk factors, would have what ...

The current treatment of hemophilia, whether due to a deficiency of factor VIII or factor IX — as reviewed in this issue of the Journal ¹ — consists of periodic replacement of the deficient factor with human blood products or recombinant proteins that ...

In this issue of the Journal, Arafah presents data indicating that some women with hypothyroidism receiving thyroxine therapy needed more thyroxine when they received estrogen therapy — a change caused by an estrogen-induced increase in the serum ...

Regeneration is an essential function of the human body. Our relatively long life span is predicated on processes that mend damaged muscles, repair broken bones, renew injured skin, replenish blood, and restructure vessels. Flies and nematodes, those ...

Do not fear to repeat what has already been said. Men need the truth dinned into their ears many times and from all sides. The first rumor makes them prick up their ears, the second registers, and the third enters.

René Théophile Hyacinthe Laënnec (1781–...

To the Editor: Ascherio et al. (Feb. 1 issue)¹ report that they found no association between hepatitis B vaccination and the onset of multiple sclerosis. Vaccination was confirmed only in the respondents who said they had been vaccinated. Exclusions ...

To the Editor: The editorial by Sapirstein et al. (Jan. 25 issue)¹ on the study by Leon et al.² of intracoronary gamma-radiation therapy to prevent restenosis speaks of the desire of the Food and Drug Administration (FDA) to navigate “a course between ...

To the Editor: The lessons from the California Tobacco Control Program, as reported by Fichtenberg and Glantz (Dec. 14 issue),¹ are critical to public health. Unlike most other states, California, using 5 cents of every 25-cent tax collected on a package ...

To the Editor: Coronary disease has been reported previously in patients infected with the human immunodeficiency virus (HIV) who are receiving protease inhibitors¹ or who are also infected with cytomegalovirus.²,³ Dilated cardiomyopathy has also been ...

In 1984 — 17 years ago — Health and Human Services secretary Margaret Heckler announced that an AIDS vaccine would be ready for testing in 2 years. Since then, nearly 60 million persons worldwide have been infected by the human immunodeficiency virus (HIV)...

Estrogen and the Risk of Breast Cancer Review Article, N Engl J Med 2001:344;276-285.. On page 276, the sentence that begins 11 lines from the bottom of the right-hand column should have read, “Flaxseed is a rich dietary source of both mammalian lignans ...