As compared with placebo, carvedilol reduced the risk of death by 35 percent and the combined risk of death or hospitalization by 24 percent.

In this study of a non-selective beta-blocker, bucindolol, there was no effect of treatment on overall mortality.

A single amino acid substitution in HLA molecules has a substantial effect on the rate of progression from HIV-1 infection to AIDS.

Total laryngectomy and total occlusion of the larynx with tracheostomy are associated with an impaired sense of taste and smell, an increased incidence of tracheobronchial infections, stomal encrustations, loss of nasal respiration, and loss of a human-...

Figure 1. A 35-year-old man with a four-month history of recurrent back pain and progressive paresthesia of both legs presented with microcytic anemia and a 10-fold elevation of alkaline phosphatase (80 percent of which was derived from bone). Although an ...

Expandable metal stents have been approved by the Food and Drug Administration for the treatment of gastrointestinal obstruction due to cancer. Although they have not been approved for use in benign disease, there are specific clinical indications for ...

Charcot described amyotrophic lateral sclerosis (ALS) in 1874. Despite progress, this creeping paralysis, known colloquially as Lou Gehrig's disease, is still not visibly affected by available therapies. However, advances in genetics have accelerated the ...

Presentation of Case

A 42-year-old man was admitted to the hospital because of pulmonary cysts.

The patient had a long history of nasal allergy, with occasional wheezing on exposure to cats; hives after ingestion of shellfish; dry eyes and mouth; and ...

The Journal has been on the World Wide Web for more than five years.¹ During that time, rapid, global dissemination of new scientific information has come to be expected. Broad searches of the medical literature and of scientific data bases are now ...

For more than a century, clinicians have noted that tachycardia, cutaneous vasoconstriction, diaphoresis, and reduced urinary output are cardinal manifestations of severe heart failure and surmised that these findings are caused by increased adrenergic ...

In this issue of the Journal, Strome and colleagues¹ describe the extraordinary case of the first successful transplantation of the larynx in a human. The recipient was a 40-year-old man who was aphonic as a result of a severe laryngeal injury. This ...

To the Editor: The DASH–Sodium Trial (Jan. 4 issue)¹ has demonstrated that a reduction in sodium intake over a period of 30 days lowers blood pressure. This finding is consistent with what more than 100 previous short-term, randomized trials have ...

To the Editor: In the report by Eskola et al. (Feb. 8 issue)¹ of the efficacy of a pneumococcal conjugate vaccine against otitis media, the data argue strongly against their conclusion that “the effect of the pneumococcal conjugate vaccine can be ...

To the Editor: The report by McClung et al. (Feb. 1 issue)¹ is unconvincing, because information is not presented to show that the women in the treatment and placebo groups had similar clinical risk factors for hip fracture. This information should have ...

To the Editor: Overdose of calcium-channel blockers remains an important cause of fatal poisoning.¹ Conventional therapy, consisting of intravenous fluids, calcium, dopamine, dobutamine, norepinephrine, and glucagon, often fails to improve hemodynamic ...

Prostate cancer is the most commonly diagnosed noncutaneous cancer and the second leading cause of death due to cancer among men living in the United States. During the year 2000, approximately 180,000 new cases were diagnosed in the United States, and ...

Why do we need another book on lung cancer when there are at least four already available? The emphasis on evidence-based medicine is what gives this book a unique approach. The editors have attempted to “present a concise overview of the data regarding ...

The importance of radiation to national security, energy policy, and environmental health has always made the determination of the effects of low-dose radiation on health a difficult problem. To establish regulations for the safe use of radiation, federal ...

In 1989, Supreme Court Justice Thurgood Marshall surmised that “declaring a war on illegal drugs is good public policy . . . [but] the first, and worst, casualty of war will be the precious liberties of our citizens.”¹ The same year, in the midst of ...