In 44 women, later pregnancies were associated with symptomatic deterioration and reduced left ventricular function.

The outbreak was nosocomial and involved person-to-person transmission.

Mutations in the keratin 8 gene were found in 5 of 55 patients with cryptogenic liver disease.

Diabetes mellitus is a heterogeneous disorder that can occur at any age.¹ Neonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare disorder that is usually associated with intrauterine growth ...

Figure 1. Fevers, chills, hypotension, and a generalized seizure occurred in a 57-year-old man who had undergone splenectomy for stage IV non-Hodgkin's lymphoma three years earlier. He was treated initially with ceftriaxone, vancomycin, and rifampin. A ...

Placebos have been reported to improve subjective and objective outcomes in up to 30 to 40 percent of patients with a wide range of clinical conditions, such as pain, asthma, high blood pressure, and even myocardial infarction.¹–³ In his 1955 article “The ...

Foreword

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's ...

Peripheral arterial disease, which is caused by atherosclerotic occlusion of the arteries to the legs, is an important manifestation of systemic atherosclerosis. The age-adjusted prevalence of peripheral arterial disease is approximately 12 percent, and ...

Presentation of Case

A 17-year-old girl (gravida 1, para 1) was admitted to the hospital because of abdominal pain, fever, and diarrhea.

The patient had been in good health before admission. Three weeks earlier, she had undergone a cesarean section ...

Peripartum cardiomyopathy is a poorly understood condition whose incidence in the United States is 1 per 3000 to 4000 live births.¹ Previous descriptions of the disorder were based on a vague definition derived from a heterogeneous group of patients,² but ...

Some myths really ought to be true. We react with surprise and pleasure when we encounter them and then believe them when they neatly and comfortably help to explain some confusing aspect of our world. Thereafter, evidence against them is unwelcome and ...

Since 1995, many liver-transplantation programs in the United States,¹,² Europe,³ and Asia⁴,⁵ have performed adult-to-adult transplantation of liver grafts from living donors. Since 1997, more than 30 U.S. transplantation programs have performed more than ...

To the Editor: In his editorial (Jan. 18 issue)¹ accompanying two studies²,³ demonstrating the safety of discontinuing prophylaxis against Pneumocystis carinii pneumonia after an antiretroviral therapy–induced rise in the CD4 cell count, Girard writes ...

To the Editor: We have reported a significantly lower rate of relapse of hematologic cancers after allogeneic blood-cell transplantation than after bone marrow transplantation in a double-blind, randomized study.¹ We believe that the reduced rate was due ...

The medical mystery in the April 5 issue¹ involved an 82-year-old woman with alkaptonuric ochronosis. Alkaptonuria is a rare inherited deficiency of homogentisic acid oxidase, leading to the accumulation of homogentisic acid in various tissues. Ochronosis ...

To the Editor: With reference to the review article by Busse and Lemanske on asthma (Feb. 1 issue),¹ we would like to raise the following points. Figure 4 fails to make it clear that several serious diseases, including type 1 diabetes,² are mediated by a ...

To the Editor: The informative review of the evaluation and treatment of low back pain in primary care by Deyo and Weinstein (Feb. 1 issue)¹ bypassed electrodiagnostic testing (by electromyography), one of the most common diagnostic procedures. ...

To the Editor: There is no consensus on the optimal treatment of polyarteritis nodosa associated with hepatitis B virus (HBV) infection. The potential risk of accelerating viral replication complicates the use of corticosteroids and cytotoxic agents. ...

Forged by the Knife is a study of black female general surgeons and their experiences of residency training. Dawson, herself a black general surgeon, wrote the book as a doctoral dissertation. Looking back on her own residency, she realized how deeply ...

This book brings a fresh approach to the already strong group of comprehensive textbooks in general surgery. As its title states, it emphasizes the basic science underlying the practice of surgery and the evidence supporting clinical decisions. The book ...

In the preface to this impressive and well-produced book, the editors state that their aim is not to describe a new surgical specialty, since most surgeons will soon need to be “geriatric surgeons,” but to assemble a comprehensive account that will allow “...