Over 200,000 persons in the United States currently receive hemodialysis,¹ and the costs of the treatment are paid principally by Medicare. Rates of reimbursement for hemodialysis providers have remained relatively constant over the past two decades and ...

Cardiac transplantation in children is a lifesaving procedure aimed at sustaining long-term, productive survival. The major short-term and long-term risks associated with transplantation that limit survival include allograft rejection, coronary ...

Rickettsia conorii infection was once considered the only tick-transmitted rickettsial infection in Europe and Africa, causing both Mediterranean spotted fever and African tick-bite fever. At that time, African tick-bite fever, which occurred after ...

For several decades, various approaches have been used to replace bone lost to trauma and disease. In 1908, Lexer¹ described attempts to reconstruct joints with newly amputated or cadaveric allografts. In more recent years, autografts² and allografts³,⁴ ...

Figure 1. Three years after undergoing heart transplantation, a 44-year-old man presented with very frequent supraventricular extrasystoles (asterisks). Myocardial rejection and clinically significant hemodynamic alterations were excluded as causes. ...

Twenty-five years ago, little was known about the causes of neurodegenerative diseases. Now, however, it is clear that they result from abnormalities in the processing of proteins. In each of these diseases, defective processing causes the accumulation of ...

In the early 1960s, shortly after the introduction of oral contraceptives, the first case reports appeared describing venous thrombosis and pulmonary emboli in women using this method of birth control. Later, myocardial infarction and stroke were also ...

Presentation of Case

A 72-year-old man was admitted to the hospital because of persistent fever and hypotension.

The patient had been well until eight days earlier, when nausea and vomiting developed, with lower abdominal pain. The next day, he was ...

It seemed like a simple plan. After the rubber top of a vial was swiped with an alcohol-soaked pledget and pierced with a needle, a dose of medication was aspirated, and any residual content was pooled for later use. What could go wrong? But this ...

The question of a viral contribution to allograft dysfunction after solid-organ transplantation has long been debated. This debate has focused primarily on cytomegalovirus, which has been identified as a risk factor for bronchiolitis obliterans in lung-...

For nearly two decades, surgeons have used cultured autologous cells for reconstructive surgery. The most notable successful application involved the removal of a specimen of skin from a badly burned patient, expansion of the keratinocytes in vitro, and ...

Like the murrain — the fifth plague in the biblical story of Exodus, which targeted cattle — a new prion disease called bovine spongiform encephalopathy (BSE) has had a devastating impact. Millions of cattle have been destroyed and billions of dollars ...

To the Editor: The findings of the Lung Health Study Research Group (Dec. 28 issue)¹ with regard to bone density should be interpreted with caution. The participants in the triamcinolone group had a nonsignificant 0.35 percent decrease in lumbar bone ...

To the Editor: The study by Glaser et al. (Jan. 25 issue)¹ identified risk factors for the development of symptomatic cerebral edema in children with diabetic ketoacidosis. Of the 61 children in whom symptomatic cerebral edema developed, 57 percent ...

To the Editor: The February 8 Case Record¹ involves a patient with Löfgren's syndrome. In his discussion of the case, Dr. Bates does not sufficiently emphasize the importance of the recognition of periarticular ankle inflammation as a particular ...

To the Editor: We question the scientific basis for several statements in Handelsman's recent review of our book, The Adonis Complex (Jan. 11 issue).¹ Handelsman dismisses anabolic-steroid–induced hypomanic syndrome (sometimes called “roid rage”) as “...

To the Editor: Hyperaldosteronism is the cause of about 0.5 to 2 percent of all cases of hypertension. Aldosterone-producing adenomas account for approximately 60 percent of the cases of hyperaldosteronism, and bilateral adrenal hyperplasia accounts for ...

This book discusses key aspects of platelet function in the regulation of hemostasis and thrombosis. It covers topics ranging from the platelet cytoskeleton to the antiphospholipid-antibody syndrome. Among the many highlights of the book is the section on ...

Fifteen years ago, H. Franklin Bunn and Bernard G. Forget published their second book on hemoglobin, entitled Hemoglobin: Molecular, Genetic and Clinical Aspects (Philadelphia: W.B. Saunders, 1986). In the first, entitled Hemoglobinopathies (Philadelphia: ...

As we enter a new millennium, it is clear that some of the greatest recent medical advances have been in the field of hematology. For example, reports indicate the early successes of gene therapy for blood diseases such as severe combined immunodeficiency ...

Napoleon once observed that history is the version of past events that people have decided to agree on. And so it is with Hematology: Landmark Papers of the Twentieth Century. This anthology of 86 papers was assembled from an initial list of 450 articles ...

Intussusception among Infants Given an Oral Rotavirus Vaccine Original Article, N Engl J Med 2001:344;564-572.. On page 564, in the list of authors “John R. Livingood, M.D.” should have read, “John R. Livengood, M.D.” On page 569, the sentence that begins ...

Waldenström's Macroglobulinemia Images in Clinical Medicine, N Engl J Med 2001:344;816.. On line 6, the IgM level should have read, “7.7 g per deciliter,” not “7.7 g per liter,” as printed.