The incidence of type 2 diabetes mellitus is increasing worldwide. Type 2 diabetes results from the interaction between a genetic predisposition and behavioral and environmental risk factors.¹ Although the genetic basis of type 2 diabetes has yet to be ...

Large-scale trials of therapy for heart failure over the past decade have shown improvements in outcome with angiotensin-converting–enzyme (ACE) inhibitors and beta-blockers.¹–⁷ In the Studies of Left Ventricular Dysfunction (SOLVD), two concurrent trials ...

Heart failure is a substantial public health problem among black Americans. It is more common in the black population than in other populations in the United States, affecting approximately 3 percent of all black adults in this country.¹,² Symptoms of ...

Congenital cytomegalovirus (CMV) infection is a leading cause of brain damage and sensorineural hearing loss in children in the United States.¹–³ Unlike preconceptional immunity against rubella or toxoplasmosis, preconceptional immunity against CMV ...

Figure 1. Two hours after the onset of fever and malaise, a 15-year-old boy began to have tachycardia and tachypnea and became unconscious. He was taken to the intensive care unit, where he was found to be in septic shock (pulse, 180; blood pressure, 70/...

Foreword

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's ...

Reports of illness resembling meningococcal disease date back to the 16th century. The description reported by Vieusseux in 1805 is generally thought to be the first definitive identification of the disease,¹ and the causative organism, Neisseria ...

In this issue of the Journal, we begin a new series of review articles focusing on clinical practice. Our goal is to provide physicians involved in patient care with information about problems that they confront on a daily basis — in a format that makes ...

For centuries, fatter and more sedentary people have been considered more likely to get diabetes. More recently, many prospective studies have established that obesity and physical inactivity are risk factors for type 2 diabetes mellitus¹ and that weight ...

Two articles in this issue of the Journal deal with the treatment of heart failure in white and black patients. One, concerning carvedilol, reports that the benefit of this beta-blocker is similar in nonblacks and blacks with chronic heart failure.¹ The ...

All physicians recognize that individual patients respond differently to medications, so that at so-called standard doses, a drug may have toxic effects in some patients but fail to produce the expected therapeutic effect in others. Our lack of ...

To the Editor: In 1998, the American College of Gastroenterology recommended that patients at high risk for hemorrhage and perforation from ulcers induced by aspirin and other nonselective nonsteroidal antiinflammatory drugs (NSAIDs) should be considered ...

To the Editor: The study conducted by von Eiff and colleagues (Jan. 4 issue)¹ might give readers the impression that a bacterial nose swab was merely a blind sample from the vestibulum nasi. The authors do not provide a precise description of the method ...

To the Editor: Gandhi et al. (Jan. 4 issue)¹ may well be correct in their conclusion that diastolic dysfunction is the primary cause of pulmonary edema in hypertensive heart failure, but the left ventricular ejection fraction is probably inadequate as ...

To the Editor: In April 1993, my colleagues and I reported in the Journal our experience with combination chemotherapy as a treatment for patients with severe refractory immune thrombocytopenic purpura.¹ We now provide long-term follow-up data on the ...

Prenatal Testing and Disability Rights centers on the tension between members of the disability-rights movement, who hold that prenatal testing for genetic disability sends a message that devalues people with disabilities, and those who view prenatal ...

The history of private care for the sick or disabled is an area much neglected by historians of health and medicine. It is a rich history, however, and one that also has a place in the history of private life, the family, and community relations. If it is ...

The Declaration of Madrid was approved by the General Assembly of the World Psychiatric Association in 1996 as a set of principles and guidelines on ethical issues relevant to psychiatry. In Ethics, Culture, and Psychiatry, a distinguished international ...

Case Records of the Massachusetts General Hospital (Case 8-2001) Case Records of the Massachusetts General Hospital, N Engl J Med 2001:344;832-839.. On page 838, the Anatomical Diagnosis should have read, “Lymphoplasmacytic lymphoma, involving occipital ...