In developing countries, typhoid fever is common, serious, and increasingly difficult to treat because of the increasing resistance of Salmonella typhi to antibiotics.¹–⁵ Typhoid fever was once thought to occur primarily in older children and young ...

White patches (leukoplakia) of the oral cavity have a well-documented potential to develop into squamous-cell carcinoma,¹–³ and when this occurs, the odds of surviving more than five years are poor.⁴,⁵ Accurate prognosis is important in patients with oral ...

Anxiety disorders are the most common psychiatric illnesses in children,¹–³ but most children with anxiety disorders do not receive treatment.⁴,⁵ Several studies have documented the safety and efficacy of drug therapy for children with obsessive–...

Heparin-induced thrombocytopenia is a syndrome of antibody-mediated thrombocytopenia that paradoxically is often associated with thrombosis.¹–⁵ Most patients with this disorder produce IgG antibodies⁶,⁷ against complexes of platelet factor 4 and heparin.⁸–...

Figure 1. Two years after emigrating from Pakistan to the United States, a 28-year-old man began to have a progressive erythematous eruption, which appeared on his right medial thigh and gradually spread to his trunk and arms (Panel A), legs, and face. ...

A survey conducted by the World Health Organization and the International Union against Tuberculosis and Lung Disease in 35 geographic sites revealed that drug-resistant tuberculosis was ubiquitous.¹,² That survey did not include temporal changes in the ...

At least 225,000 people in the United States will die suddenly this year from coronary heart disease before they reach a hospital.¹,² In addition, an estimated 370,000 to 750,000 patients will have a cardiac arrest and undergo attempted resuscitation ...

Presentation of Case

A 19-year-old man was admitted to the hospital because of headaches and hypertension.

The patient had been well until two years earlier, when he began to have episodic mild headaches that resolved spontaneously. Two months before ...

There is a growing appreciation of the huge health threat posed by increasingly resistant infectious diseases, especially in tropical areas of the developing world. Only with improved water, sanitation, housing, and education can enteric, parasitic, ...

Oral cancer is the most common neoplasm of the head and neck. Worldwide, the annual incidence of new cases exceeds 300,000. The disease causes great morbidity, and the five-year survival rate of less than 50 percent has not improved in more than two ...

Anxiety disorders represent the most common group of serious psychiatric conditions affecting children and adolescents. In a community-based study, approximately 3 percent of 9-to-17-year-olds had a diagnosable anxiety disorder that caused serious ...

To the Editor: In their study of the prevalence of multidrug-resistant Streptococcus pneumoniae in the United States, Whitney et al. (Dec. 28 issue)¹ report differences in the prevalence of resistance according to region, age, and race. We investigated ...

To the Editor: The article by Inskip et al. (Jan. 11 issue)¹ provides reassuring findings that cellular-telephone use is not associated with an increased risk of brain tumors, but the study has some limitations that are due to its retrospective design. ...

To the Editor: Allergic symptoms are the result of an inflammatory process triggered by an allergen or allergens to which a patient has generated antibodies after a previous exposure. Dr. Kay's review article on allergic diseases (Jan. 4 issue)¹ ...

To the Editor: The hostile review by Berkwits (Jan. 4 issue)¹ of my book The Two-Headed Boy, and Other Medical Marvels contains several errors and gives potential readers a deeply misleading image of the book. For instance, Berkwits wrongly states that ...

To the Editor: Hypertrophic cardiomyopathy and fibromuscular dysplasia of the superior mesenteric artery that causes ischemic colitis are rare clinical entities. Their coexistence would probably be considered incidental, but they have some similarities. ...

For anyone wanting all the details of the development of paclitaxel (Taxol) from its very beginning until it was marketed as a new, natural-product anticancer drug, this book is an excellent source of information. It is carefully researched and detailed, ...

Lung cancer remains the leading cause of cancer-related death in men, and in women it has surpassed even breast cancer. The primary cause of lung cancer in up to 90 percent of patients is smoking, and it is estimated that bronchiogenic carcinoma will ...

Is breast cancer a social problem or a medical disease? Of course it is both, but by posing such a dichotomy, Breast Cancer: Society Shapes an Epidemic raises disturbing questions and obscures potential answers. At times, this book degenerates into ...