Renal transplantation is the treatment of choice for most patients with end-stage renal disease. However, because of the wide disparity between the supply of organs and the demand,¹ many patients wait three to four years for a suitable organ. Allograft ...

A varicella vaccine containing live attenuated virus (Oka strain) was developed in Japan in the early 1970s.¹ In the United States, the vaccine was approved by the Food and Drug Administration in 1995 and is recommended for persons 12 months of age or ...

Interferon-α is an important cytokine in the early immune response to viral infection and has both antiproliferative and antiviral properties.¹ Interferon alfa has been used at high doses (1 million to 50 million U) for the treatment of malignant ...

Aspirin at low doses and other nonsteroidal antiinflammatory drugs (NSAIDs) are major causes of upper gastrointestinal bleeding worldwide. Low-dose aspirin is increasingly used for cardiovascular prophylaxis, but it doubles the risk of bleeding ulcers, ...

Figure 1. A 61-year-old man with metastatic colon carcinoma was hospitalized with small-bowel obstruction. A Cantor tube was placed in the stomach with instructions to the nurse to advance the tube gradually and periodically until it progressed into the ...

Nonmelanoma skin cancer is the most common cancer in the United States, with over 1.3 million cases expected to occur in the year 2001. Approximately 80 percent of nonmelanoma skin cancers are basal-cell carcinomas, and 20 percent are squamous-cell ...

Drug interactions are an important factor in the treatment of patients with human immunodeficiency virus (HIV) infection. The complexity of current drug regimens for such patients requires that clinicians recognize and manage drug interactions. ...

Presentation of Case

A 53-year-old woman was admitted to the hospital because of radiographically evident pulmonary nodules.

The patient had a long history of seropositive rheumatoid arthritis, which was usually well controlled with naproxen. Six years ...

Kidney transplantation is the best treatment for patients with end-stage renal disease. The first six months after a technically successful transplantation is, however, often complicated by episodes of renal dysfunction that may have various causes. Rapid ...

The live attenuated varicella vaccine is the only vaccine licensed for the prevention of a disease caused by a human herpesvirus. The origin of the vaccine can be traced back to 1952, when Weller and Stoddard recovered varicella–zoster virus by cell ...

Prescription-drug coverage is now provided for the vast majority of persons enrolled in private health insurance, Medicaid, or plans for government employees, veterans, and active military personnel. The 40 million elderly and disabled persons enrolled in ...

To the Editor: In the November 30 issue of the Journal, four articles addressed financial conflicts of interest for academic investigators working with industry. The articles by Lo et al.¹ and McCrary et al.² provide important data and insight into the ...

To the Editor: Drazen and Koski (Nov. 30 issue)¹ argue persuasively that research institutions should adopt a uniform policy regarding financial conflicts of interest in order to protect the integrity of clinical research. In articulating their case for ...

To the Editor: Kotani and colleagues (Nov. 23 issue)¹ recommend intrathecal methylprednisolone acetate for treatment of intractable postherpetic neuralgia due to persistent inflammation. But the abnormalities in the cerebrospinal fluid and on magnetic ...

To the Editor: Mandel and associates (Nov. 30 issue)¹ show that either annual or biennial fecal occult-blood testing significantly reduces the incidence of colorectal cancer. Their findings were primarily the result of using the equivalent of the ...

To the Editor: Health care for Hmong immigrants from Southeast Asia to the United States has been associated with major social, cultural, and communication problems.¹ To determine whether the health care received by Hmong patients differs from that ...

America's obsession with sports is evident just from the salaries of some professional athletes, which rival the entire budgets of many academic medical centers. The increased interest in sports and physical fitness has filled the offices of primary care ...

The Olympic motto, “Citius, Altius, Fortius” (“swifter, higher, stronger”), has pushed many athletes to the limits of human endurance. When the 40,000-m Olympic marathon was run in 2 hours, 58 minutes, and 50 seconds in 1896, who could have imagined that ...

Muscle pain is common. Fibromyalgia occurs in 2 percent of the general population (in 0.5 percent of males and 1.5 percent of females) and is diagnosed in approximately 15 percent of patients seen in rheumatology clinics and up to 10 percent of those seen ...