Despite advances in the diagnosis and treatment of breast cancer, more than 44,000 women in the United States will die this year of metastatic disease.¹,² Although objective responses to some chemotherapy regimens are common, few patients with metastatic ...

Solid-organ transplantation between donors and recipients with incompatible blood groups is usually contraindicated because of the high risk of hyperacute rejection. Such rejection occurs when preexisting serum anti-A or anti-B antibodies (natural ...

La Crosse virus is the most pathogenic member of the California encephalitis serogroup. It was first isolated from the brain of a four-year-old child who had died of “rural encephalitis” in La Crosse County, Wisconsin.¹ The virus is transmitted by the ...

The cause of ulcerative colitis is not known. Reports of a low rate of appendectomy among patients with ulcerative colitis have therefore gained widespread attention.¹–¹¹ It has been proposed that the excision of the appendix may have an immune-modulating ...

Figure 1. A 47-year-old woman had been given a diagnosis of a malignant ovarian tumor in 1995. Initial treatment included a radical hysterectomy and postoperative chemotherapy with cisplatin and radiotherapy of the pelvis. Diffuse peritoneal relapse of ...

Figure 1. A 65-year-old man had an 18-month history of slowly progressive swelling and discoloration of both ears, fatigue, night sweats, weight loss, occipital headaches, and photophobia. On examination, his ears were swollen and purplish and had several ...

The introduction of highly active combination antiretroviral therapy has been accompanied by increased concern about the costs of care for patients with human immunodeficiency virus (HIV) infection.¹–⁷ Some investigators have reported an association ...

In the past decade, there have been dramatic changes in the treatment of human immunodeficiency virus (HIV) disease.¹–³ The use of combination antiretroviral therapy has led to decreased morbidity and mortality among patients with advanced HIV infection ...

Presentation of Case

A 61-year-old man was admitted to the hospital because of transient quadriplegia and apnea.

The patient had been well until the morning of admission, when stiffness and pain developed in his neck after he turned his head. The pain was ...

Much of the fundamental cancer research of the past two decades has focused on identifying the molecular and genetic changes that cause malignant transformation. These abnormalities can be attractive targets for the development of anticancer treatments. ...

Cardiac transplantation has now been performed for 15 years as therapy for neonates and infants with lethal myopathic or structural heart disease. Such transplantation has been stimulated by both the needs of the infants and the promise of an immunologic ...

Dramatic declines in the incidence of AIDS and the number of deaths from this disease began in the United States in 1996, in association with the widespread use of potent combinations of antiretroviral drugs. Subsequently, the rates of decline have slowed ...

It should be a no-brainer. Every citizen of the most prosperous nation in the world should have basic health insurance. Yet lack of health insurance remains one of the most glaring examples of how the United States differs from other countries.¹,² Despite ...

To the Editor: Albert et al. (Nov. 9 issue)¹ demonstrate an inverse association between the frequency of vigorous exercise at base line and sudden death from cardiac causes during or shortly after single episodes of vigorous exercise over the ensuing 20 ...

To the Editor: Kannus et al. (Nov. 23 issue)¹ report that the use of external hip protectors reduces the risk of hip fracture in elderly people by 60 percent. We believe that there is uncertainty about the magnitude of the effect because the analysis was ...

To the Editor: A large variety of infectious agents are associated with acute and chronic myocarditis, as discussed by Feldman and McNamara (Nov. 9 issue).¹ In areas infested with vector ticks of Lyme borreliosis, infection with Borrelia burgdorferi may ...

To the Editor: Dr. Arm's discussion (Sept. 28 issue)¹ of a case of the Churg–Strauss syndrome in a man who was receiving multiple asthma medications, including montelukast (Singulair, Merck), did not include important medical history. Information ...

To the Editor: We report on the phenomenon of intracardiac thrombosis with features of Löffler's syndrome observed in conjunction with interleukin-2 therapy.

Patient 1, a 26-year-old woman with stage IV Hodgkin's disease, began to receive a continuous ...

“I, Dr. Grim, will kill you if you touch this IV.” This is the sign taped by Dr. Pamela Grim above the sickest patients in her makeshift intensive care unit — a fly-ridden tent — during a meningitis epidemic in Nigeria, where she works as an emergency ...

An article featured in the January 17, 2001, business section of the New York Times, “When Gene Sequencing Becomes a Fact of Life” by Andrew Pollack, reported the development of a new way to sequence the genes of the human immunodeficiency virus. This ...