Hypertension affects almost 50 million people in the United States and places them at higher risk for cardiovascular diseases.¹,² Furthermore, this risk increases with progressive elevations in blood pressure, beginning at even normal levels of blood ...

Staphylococcus aureus is one of the most common causes of both endemic and epidemic infections acquired in hospitals, which result in substantial morbidity and mortality. In U.S. hospitals in the National Nosocomial Infections Surveillance system, S. ...

It is a clinical paradox that patients hospitalized with congestive heart failure may later be noted to have normal systolic function, as evidenced by a normal left ventricular ejection fraction (≥0.50).¹–⁵ In this situation, the heart failure has been ...

Bleeding from esophageal varices is an important complication of portal hypertension in patients with cirrhosis and is associated with a high mortality rate.¹,² Hemostasis must be achieved immediately to control acute bleeding and to prevent early ...

Figure 1. A 71-year-old woman with primary biliary cirrhosis had recurrent lower gastrointestinal bleeding requiring transfusions. At colonoscopic examination, large rectal varices were the only apparent source of bleeding (Panel A). A transjugular ...

Allergic rhinitis, asthma, and atopic eczema are among the commonest causes of chronic ill health. These diseases are increasing in prevalence, and they add considerably to the burden of health care costs. In Sweden, for example, the number of children ...

Misoprostol is a prostaglandin E₁ analogue that has been approved by the Food and Drug Administration (FDA) to be taken orally for the prevention and treatment of gastric ulcers associated with the use of nonsteroidal antiinflammatory drugs. It has also ...

Stage

A 58-year-old man receiving hemodialysis after failed renal transplantation was admitted with unstable angina. He had a history of hypertension, diabetes mellitus, ischemic heart disease, and transplant-related immunosuppression of several years' ...

The 1997 Dietary Approaches to Stop Hypertension (DASH) trial¹ marked an important advance in the study of lifestyle factors as they relate to health and disease. Its findings were immediately incorporated into the report of the Joint National Committee ...

When it enters the blood, Staphylococcus aureus is one of the most lethal human pathogens. In 1941, Skinner and Keefer reported that 82 percent of 122 patients treated at Boston City Hospital for S. aureus bacteremia died of their infection.¹ From 1990 to ...

There are 4.6 million people in the United States with heart failure today, and 550,000 new cases are being reported annually.¹ Approximately 30 to 50 percent of patients with heart failure have a normal or nearly normal left ventricular ejection ...

The article by Goldberg et al. in this issue of the Journal reviews the evidence supporting the use of misoprostol in women at various stages of pregnancy.¹ The authors identified more than 200 studies involving more than 16,000 women who received ...

The review article in this issue by Goldberg et al. and the accompanying editorial by Hale and Zinberg were sent to G.D. Searle, the manufacturer of misoprostol, which offers the following:

To the Editor: The article by Goldberg et al. on misoprostol and ...

To the Editor: Sutter et al. (Sept. 14 issue)¹ support the use of oral poliovirus vaccine (OPV) plus inactivated-poliovirus vaccine (IPV) to enhance levels of immunity, especially against type 3 poliovirus. In an accompanying editorial, John² supports an ...

To the Editor: On the basis of prospective data from a large cohort of patients with hypertrophic cardiomyopathy, Spirito et al. (June 15 issue)¹ report that the magnitude of left ventricular hypertrophy is a significant predictor of sudden death. ...

To the Editor: Jones et al. (Aug. 17 issue)¹ describe transplantation of a hand and provide one year of follow-up data on the recipient. Although one can applaud the technical accomplishment, their use of the term “successful” must be challenged. The ...

To the Editor: In their review article (March 2 issue), Gilden et al.¹ describe complications involving the peripheral and central nervous system after reactivation of varicella–zoster virus. They do not mention Guillain–Barré syndrome as a complication.

To the Editor: The July 27 Case Record¹ involved a patient with human immunodeficiency virus (HIV) infection who was given a diagnosis of osteomyelitis due to infection with Mycobacterium avium complex. The discussant stated that fewer than 50 cases of ...

To the Editor: Bone marrow transplantation can eliminate sickle cell disease and halt end-organ damage.¹,² However, the applicability of the procedure is limited because of the toxic effects associated with conventional bone marrow transplantation. ...

To the Editor: CD20 antigen is expressed on most B lymphocytes. Therefore, humanized monoclonal antibodies to CD20, especially rituximab, specifically kill lymphomatous and normal B lymphocytes by means of cytotoxicity and apoptosis.¹ Few infections have ...

To the Editor: The prognosis for patients with Behçet's disease and pulmonary involvement is poor.¹ Half the patients die within three years after the onset of hemoptysis.² We describe the successful treatment of two patients with Behçet's disease and ...

Frances Ashcroft was “galvanized” to write this intriguing book when a friend suggested she submit an entry for the Wellcome Trust prize, awarded every two years to the British life scientist who writes the best book for nonscientists. Ashcroft, professor ...

If Wilder Penfield's classic diagram of the cerebral cortex is to be believed, we each carry within us a homunculus, a little monster whose distorted, disassembled body parts are wired into our brains and configured in proportion to our sensorimotor ...

American Psychiatry after World War II is the American Psychiatric Association's tribute to the first 50 years of the field's second century. Intended to follow in the footsteps of the centennial history of psychiatry, published in 1944, this book is ...

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis Original Article, N Engl J Med 2000:343;1586-1593.. On page 1586 of the print version of this article, in the Abstract, the Conclusions should have referred to “...

Biologic Therapy for Rheumatoid Arthritis Editorial, N Engl J Med 2000:343;1640-1641.. On page 1640, the sentence that begins five lines from the bottom of the right-hand column should have read, “The finding of demyelinating syndromes is of interest, and ...