Alzheimer's disease is the most common cause of dementia late in life, affecting approximately 8 percent of people who are 65 years of age or older.¹ Clinically diagnosed Alzheimer's disease is preceded by gradual, progressive memory loss. Neuritic ...

Elevated plasma levels of factor VIII are associated with an increased risk of venous thrombosis.¹–³ In the Leiden Thrombophilia Study, plasma levels of factor VIII above 150 IU per deciliter were associated with a quintupled risk of venous thrombosis,¹ ...

Diarrheal disease is a leading cause of illness and death in children worldwide.¹,² Many of the deaths are caused by dehydration resulting from loss of water and electrolytes due to intestinal malabsorption or increased secretion. Replacement of these ...

In 1996, the Louisville Hand Transplant Team was formed to examine the possibility of performing a human hand transplantation. One of our first goals was to develop procedures for the transplantation of allografts of extremities in large animals.¹,² In ...

Figure 1. A 62-year-old man presented with abdominal pain and nausea. On examination, his abdomen was distended and diffusely tender. He had been receiving oral anticoagulants for more than two years after an extensive inferoposterolateral myocardial ...

Cardiovascular disease is the most common cause of death in both men and women in the United States and is increasingly recognized as having sex-specific features. Clinical and epidemiologic studies have shown that men and women with cardiovascular ...

The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr.¹ Four years later, in 1968, EBV was shown to be the etiologic agent of heterophile-positive ...

Presentation of Case

A 69-year-old woman was admitted to the hospital because of a pulmonary arterial obstruction.

The patient had been well until several months before admission, when an intermittent, nonproductive cough developed. Ten days before ...

Alzheimer's disease is a chronic disorder with a gradual onset and slowly progressive course that is characterized by an inevitable deterioration in cognitive function. To develop new methods to prevent and treat Alzheimer's disease, we must be able to ...

Limb transplantation has long been of interest to surgeons. The legend of the pysician twins Saint Cosmos and Saint Damian, who transplanted a whole leg in a.d. 348, has come down to us from antiquity. The first successful transplantation of an allograft ...

Just a decade ago, in September 1990, public and political concern about the underrepresentation of women in major clinical trials,¹ especially trials focusing on cardiovascular disease, resulted in the establishment of the Office of Research on Women's ...

To the Editor: In her editorial, Dr. Angell (May 18 issue)¹ discusses the increasing ties between academic medical institutions and industry. She notes that the benefit for the former is needed cash and that the benefit for the latter is access to ...

To the Editor: Although Dr. Bodenheimer (May 18 issue)¹ makes a number of cogent observations about the sponsorship of clinical research by the pharmaceutical industry, his report lacks balance. As an employee of a contract-research organization (CRO), I ...

To the Editor: Buchthal et al. (March 23 issue)¹ report an abnormal, reversible decrease in the myocardial phosphocreatine:ATP ratio during mild handgrip exercise, a finding suggestive of ischemia, in 7 of 35 women with angina and no angiographically ...

To the Editor: Ridker et al. provided a stimulating article on inflammatory markers and cardiovascular disease in women (March 23 issue).¹ Not surprisingly, the popular press picked up on the article and gave their findings prominent coverage. It is not ...

To the Editor: The differential diagnosis of bradycardia reviewed recently by Mangrum and DiMarco (March 9 issue)¹ should include Lyme carditis.²–⁴ Here, we describe a patient with Lyme carditis.

A 42-year-old patient presented with acute first-to-third-...

To the Editor: At the end of his review of Marihuana and Medicine, Benson (Sept. 9 issue)¹ states, “The editors' drug-control bias obscures the promise of drug development.” Dr. Benson is the senior editor of the 1999 report by the Institute of Medicine, ...

To the Editor: Patients with heparin-induced thrombocytopenia are at high risk for thromboembolic complications. Heparin-induced thrombocytopenia is caused by heparin-related and platelet-activating antibodies.¹ These antibodies, referred to as HIT ...

More than 150 million people in the world have diabetes, the prevalence of which is increasing so rapidly that the management of diabetes is a priority in all branches of medicine. The new therapies and rapidly evolving evidence are making us all ...

Iron is so critical for cell function and survival that, paradoxically, a heritable abnormality that causes increased iron absorption may actually confer a selective advantage. Although this idea may appear simplistic, it could explain how a genetic ...

This book is an unparalleled and valuable compendium of data for anyone interested in women's health. The editors have done a superb job: despite their choice of enlisting almost 200 experts as contributing authors, the chapters have a consistently ...

The Acute Respiratory Distress Syndrome Review Article, N Engl J Med 2000:342;1334-1349.. On page 1336, in the legend to Figure 1, the next-to-last sentence should have read, “There are reticular opacities and diffuse ground-glass opacities throughout ...

Collective Bargaining for House Staff Correspondence, N Engl J Med 2000:342;1919-1921.. On page 1919, the sentence that begins on line 5 of the letter should have read, “Physicians for Responsible Negotiation, a national labor organization formed by the ...