Hyperglycemia is associated with adverse outcomes of pregnancy in women with gestational or preexisting diabetes mellitus. The principal approach to glycemic control in pregnant women with diabetes is dietary therapy, with the addition of insulin when ...

There are numerous studies showing that elevated blood levels of troponin T or I are associated with an increased risk of cardiac events after an episode of unstable coronary artery disease.¹–⁵ In addition, elevated levels of markers of inflammation in ...

The discovery of inflammatory cells in the cap of atherosclerotic plaques led to the postulate that inflammation has a key role in the cascade of events leading to plaque rupture.¹,² Supporting this idea are recent reports that levels of plasma markers of ...

Immunosuppressive regimens of glucocorticoids combined with cytotoxic drugs, particularly cyclophosphamide, are effective for the treatment of severe proliferative lupus nephritis.¹–³ However, cyclophosphamide has immediate and cumulative adverse effects, ...

Histoplasmosis may occur either after primary infection or after reactivation of latent infection, and its incidence among immunocompromised persons, including recipients of organ transplants, is increasing.¹–³ A variety of infectious agents are known to ...

Figure 1. A 34-year-old mother of two children had had menometrorrhagia, lethargy, and episodic abdominal pain for several months. A trial of oral contraceptives provided no relief. Dilation and curettage was performed; staining of the tissue with ...

Presentation of Case

A boy who was six years and five months old was admitted to the hospital because of vertebral compression fractures.

The boy had been well until six months earlier, when he began to have back pain after falling on his back. The pain ...

Gestational diabetes mellitus has been a contentious subject since it was first described. From a global perspective, authors have questioned its very existence, the burden of morbidity that it causes, and whether making the diagnosis simply increases the ...

The past decade has been characterized by growing interest in the idea that atherosclerosis is an inflammatory disease¹ and by the finding that serum levels of markers of inflammation can be used to predict the risk of cardiovascular events.² In this ...

Until the pathogenesis of nephritis due to systemic lupus erythematosus has been unraveled, optimal treatment for patients with this disease will remain an elusive goal. When the causes of lupus nephritis become known, we should be able to design specific ...

Dear Vice President Gore and Governor Bush:

Medical care and issues related to it are of vital interest to all Americans. As we approach the presidential election, physicians across the country are concerned about how the federal government influences ...

To the Editor: Clopidogrel is indicated for the reduction of atherosclerotic events (myocardial infarction, stroke, and death from vascular causes) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established ...

To the Editor: In the June 22 issue, Concato et al.¹ compared 5 systematic reviews of randomized, controlled trials and observational studies on the same topic, and Benson and Hartz² evaluated 18 case studies of randomized, controlled trials and ...

To the Editor: The pituitary gonadotropins luteinizing hormone and follicle-stimulating hormone regulate the ovarian production of sex steroids. According to the two-cell–two-gonadotropin theory, luteinizing hormone stimulates thecal cells to produce ...

To the Editor: The May 4 review of my book Anthrax: The Investigation of a Deadly Outbreak ¹ contains a historical error in need of correction. The pathoanatomical analysis proving that victims of the 1979 Sverdlovsk epidemic died of inhalatory anthrax ...

To the Editor: A 77-year-old man came to the emergency room with a two-day history of sharp bilateral testicular pain. He had no history of trauma, fevers, chills, abdominal or back pain, dysuria, hematuria, penile discharge, frequency, or urgency. The ...

Renal-cell carcinoma is sometimes said to be the cancer that is most resistant to both chemotherapy and radiation therapy. Once renal-cell carcinoma has spread beyond the kidney, therapeutic options are limited. In the United States alone, 12,000 people ...

If one were to draw a map of publications on hypertension showing clumps of textbooks, clusters of manuals, and blocks of volumes of proceedings, this book would occupy a somewhat solitary position. In fact, it is a proper book — a textbook written by two ...

I once knew a hematologist who could recognize a patient from the blood smear — the teardrop cells, giant platelets, and nucleated red cells signaled the presence in the waiting room of the woman with myelofibrosis. Back then, hematologists examined the ...

Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer Original Article, N Engl J Med 2000:343;162-168.. On page 162, the first sentence in the right-hand column should have read, “Colorectal cancer is the second leading cause of death ...