Asthma is a disease of chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness.¹–³ Recent studies have demonstrated that asthma can be associated with impaired lung growth during childhood and with a ...

Because they are effective, inhaled corticosteroids are widely used to treat children with asthma.¹–³ However, many physicians are concerned about the potential adverse effects of long-term corticosteroid treatment, particularly effects on growth.

In many ...

The endogenous circadian pacemaker oscillates with a period that is slightly longer than 24 hours and that therefore requires synchronization, or entrainment, to the 24-hour day. Entrainment involves regular adjustments of the circadian pacemaker, known ...

Through an agreement among U.S. transplantation centers, the United Network for Organ Sharing (UNOS) established a program in 1987 to ship kidneys anywhere in the United States to a recipient who had the same HLA-A, B, and DR antigens as the donor. By ...

Figure 1. An eight-year-old boy was referred to the nephrology clinic with a two-year history of painless, gross macroscopic hematuria. He had recently arrived from Somalia and stated through an interpreter that with each urination he passed bright red ...

There are more than 2 million women in the United States alone who are living with a history of breast cancer.¹,² Screening programs have increased the number of women in whom invasive or noninvasive breast cancer has been diagnosed, and earlier detection ...

The compartmentalization of functions into distinct membrane-bound organelles is a central characteristic of cells. The protein and lipid composition of these organelles is unique, a factor that is vital for their proper function. This necessitates ...

Presentation of Case

A 32-year-old man was evaluated for a lesion of the urinary bladder.

The patient had been well until 16 months earlier, when he had an episode of perineal pain associated with painful ejaculation and a brown, curdled ejaculate. There ...

Long-term administration of systemic corticosteroids is a cause of impaired growth.¹ Trials comparing inhaled corticosteroid preparations with other treatment regimens in nearly 600 children with asthma found that inhaled beclomethasone had greater ...

Disturbances in circadian rhythms often result in disturbances in sleep. Examples include syndromes in which sleep time is delayed or advanced, the sleeping problems associated with jet lag and shift work, and the sleep disorders that occur in totally ...

To the Editor: The findings of Cassidy et al. (April 20 issue)¹ suggest that radical changes are needed in the tort system of automobile insurance that is common throughout the United States, in which injured claimants can sue for pain and suffering ...

To the Editor: In their Sounding Board article on nonaccredited medical education in the United States (May 25 issue),¹ Drs. Kassebaum and Cohen make several inaccurate and misleading statements.

The common definition of “accreditation” is review and ...

To the Editor: Lamivudine, a nucleoside analogue, has shown promising results in the treatment of hepatitis B virus (HBV) infection through its inhibitory action on reverse-transcriptase activity.¹,² Lamivudine has been used to treat acute hepatitis B ...

To the Editor: It has been suggested that nodular lymphocyte-predominant Hodgkin's disease and T-cell–rich B-cell lymphoma are closely related entities.¹ Indeed, the lymphocytic and histiocytic (L&H) cells in nodular lymphocyte-predominant Hodgkin's ...

To the Editor: Treatment of children may be difficult because of a shortage of properly formulated or approved drugs.¹ In the Netherlands and elsewhere, many drugs are not approved for use in children, and some drugs are often used outside the terms of ...

This short paperback book (containing less than 200 pages of text) assembles the considerable evidence questioning the value of prenatal care as traditionally offered and universally recommended in the United States and suggests changes. Although Strong ...

Shortly after his partner of five years was infected with the human immunodeficiency virus (HIV) in 1982, the author found himself besieged and bewildered by public attitudes toward persons with the acquired immunodeficiency syndrome (AIDS). As the death ...

The title on the cover of this book appears forbidding because it implies that the book will be an exhaustive treatise on all the genetic causes of neurologic disease. On the contrary, the book gives a concise overview of a rapidly expanding, and at times ...

Pyomyositis Complicating Acute Bacterial Endocarditis in an Intravenous Drug User Correspondence, N Engl J Med 2000:342;1614-1615.. On page 1614, the legend to Figure 1 should have read, “The irregular, lucent area deep to the soleus muscle represents an ...

The Immune System (First of Two Parts) Review Article, N Engl J Med 2000:343;37-49.. The ligand for integrin-mediated arrest and adhesion of neutrophils to the vascular endothelium is intercellular adhesion molecule 1 (ICAM-1), not E-selectin as shown in ...