Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system that most commonly affects women, with an onset typically between 20 and 40 years of age. A diagnosis of clinically definite multiple sclerosis requires the ...

The antimetabolite fluorouracil is widely used to treat metastatic colorectal cancer, the second-leading cause of death from cancer in North America.¹ The drug inhibits thymidylate synthase, an enzyme required for the synthesis of DNA.² It is commonly ...

Rupture of coronary-artery plaques, resulting in thrombotic occlusion, is implicated in the pathogenesis of acute myocardial infarction.¹–⁶ Plaque disruption is thought to be a function of the interplay between factors intrinsic to the plaque and ...

Children with chronic renal failure are at high risk for growth retardation and decreased adult height.¹ Therapy with recombinant human growth hormone increases the growth rate and improves the standardized height (height expressed as the number of ...

Hereditary hemorrhagic telangiectasia, or Rendu–Osler–Weber disease, is an autosomal dominant disease characterized by angiodysplastic lesions (telangiectases and arteriovenous malformations) that affect many organs, including the skin, lungs, ...

Figure 1. An 81-year-old woman with long-standing hypertension and diabetes mellitus was evaluated for increasingly frequent and longer episodes of epigastric pain soon after eating. She grew progressively more fearful about eating because of the pain and ...

More than 100 years has passed since Charcot, Carswell, Cruveilhier, and others described the clinical and pathological characteristics of multiple sclerosis.¹ This enigmatic, relapsing, and often eventually progressive disorder of the white matter of the ...

Presentation of Case

A 25-year-old man was admitted to the hospital because of asthma, cardiac failure, diarrhea, and weakness of the right hand.

He had been well until two years earlier, when asthma developed. It was managed with bronchodilator ...

For more than 40 years, fluorouracil has been the mainstay of treatment for advanced colorectal cancer, the second leading cause of cancer-related death in the United States. The drug is thought to act primarily by inhibiting the enzyme thymidylate ...

To the Editor: The article by Peppard et al. (May 11 issue)¹ provides interesting epidemiologic data that suggest a causal role of sleep-disordered breathing in hypertension. If the breathing disorder is symptomatic (e.g., obstructive sleep apnea), the ...

To the Editor: Herrmann et al. (June 1 issue)¹ concluded that “oral sildenafil has no direct adverse cardiovascular effects in men with severe coronary artery disease.” However, they studied only a single dose of sildenafil in only 14 men, in an open-...

To the Editor: Michaelides et al. (Feb. 4, 1999, issue)¹ reported that the use of right precordial leads has the same diagnostic accuracy as thallium-201 scintigraphy during exercise testing for the detection of coronary artery disease. We evaluated 900 ...

To the Editor: Vascular complications cause serious morbidity in patients with diabetes mellitus. Two such complications are diabetic nephropathy and restenosis after percutaneous transluminal coronary angioplasty. There is currently scant evidence of a ...

To the Editor: In his Sounding Board article (May 11 issue),¹ Mills points out that some have called for an increase in the level of fortification of foods with folic acid,² even though the effect of the current level of fortification of 140 μg of folic ...

To the Editor: Thalidomide has recently been shown to be effective for the treatment of refractory myeloma.¹,² We report a case of life-threatening toxic epidermal necrolysis with the combined use of thalidomide and dexamethasone in a patient with ...

To the Editor: Huntington's disease is an inherited, progressive, mentally and physically disabling disorder characterized by choreoathetoid movements, dementia, and occasionally psychosis.¹ Rejection of assistance by many patients makes this an ...

The first sentence of this excellent book sums up both its content and the reason one should read it: “It is ironic that the professional and popular discourse surrounding Alzheimer disease (AD), whose most dreadful feature is the obliteration of memory, ...

Despite, or maybe because of, the fast pace necessitated by the increasingly complex structure of medical care, the clinical neurologist needs to reflect on the dilemmas that often arise in daily practice. The topics in this book resonate with situations ...

This book is a timely, comprehensive monograph about a highly noticeable condition characterized by enlarging areas of cutaneous depigmentation. Current therapies are generally unsatisfactory, and recent advances justify this up-to-date review. The book ...

The Effect of Previous Coronary-Artery Bypass Surgery on the Prognosis of Patients with Diabetes Who Have Acute Myocardial Infarction Original Article, N Engl J Med 2000:342;989-997.. On page 993, the sentence that begins on line 12 of the left-hand ...

Lack of Effect of a High-Fiber Cereal Supplement on the Recurrence of Colorectal Adenomas Original Article, N Engl J Med 2000:342;1156-1162.. On page 1161, four additional names should have appeared in the Appendix: Andrew Collins, M.D., George Walker, ...