Exercise testing is widely used to detect coronary heart disease and to assess the short- and long-term prognosis in patients with the disease. Numerous studies have shown that an ischemic ST-segment response to exercise is a powerful predictor of major ...

Nonsteroidal antiinflammatory drugs, including low-dose aspirin, induce gastrointestinal complications.¹–³ Although new and potentially safer nonsteroidal antiinflammatory drugs (such as cyclooxygenase-2 inhibitors) are now in use,⁴ it is uncertain ...

A parental history of premature coronary artery disease is an important risk factor for cardiovascular events.¹–⁴ The risk of ischemia as evidenced by electrocardiography is about 40 percent higher and the risk of death from cardiac events is 2.5 to 7 ...

In patients who have myasthenia gravis, antibodies that react with nicotinic acetylcholine receptors in muscle disrupt transmission at the neuromuscular junction.¹ Normally, nicotinic acetylcholine receptors also mediate fast synaptic transmission through ...

Androgen-insensitivity syndromes in 46,XY fetuses result in various degrees of impairment in genital virilization.¹ These syndromes are caused by mutations in the androgen receptor gene that result in decreased binding of androgen to the receptor.²–⁹ As a ...

Figure 1. A 76-year-old woman had iron-deficiency anemia, a hematocrit of 24 percent, and a positive test for occult blood in stool. For several years, she had been taking 400 mg of etodolac twice a day for rheumatoid arthritis; one tablet of enteric-...

Thromboangiitis obliterans (Buerger's disease) is a nonatherosclerotic segmental inflammatory disease that most commonly affects the small and medium-sized arteries, veins, and nerves of the arms and legs.¹ Von Winiwarter first described a patient with ...

Presentation of Case

A 69-year-old woman was admitted to the hospital because of weakness, cough, and low-grade fever.

The patient had end-stage renal disease due to membranous glomerulonephritis (Figure 1 and Figure 2) and a long history of hypertension. ...

Exercise stress testing is a well-established procedure that has been in widespread clinical use for more than 30 years.¹ The great majority of exercise stress tests are performed in patients with known or suspected coronary artery disease. Exercise ...

Clinical disorders that arise as a result of resistance to the intracellular action of a hormone are being characterized with increasing frequency. Perhaps the most notable example is the testicular feminization syndrome, now referred to as the complete ...

To the Editor: Rascol et al. (May 18 issue)¹ summarize the results of their study by stating that Parkinson's disease is best managed with ropinirole alone as the initial treatment, with levodopa used as a supplemental, second step if necessary. This ...

To the Editor: In commenting on hyponatremia secondary to the absorption of sodium-free irrigant solutions from an operative site, Adrogué and Madias (May 25 issue)¹ refer only to men who are undergoing prostate surgery. However, the syndrome may occur ...

To the Editor: In their article, the Italian Group for Antiemetic Research (May 25 issue)¹ did not give information about the mean number of vomiting episodes during days 2 through 5 in patients who had emesis; the times at which these episodes occurred ...

To the Editor: Prostate-specific antigen (PSA) is a protein produced almost exclusively by the prostate. Although various tissues in females have been found to produce very small amounts of PSA, serum PSA levels in females are quite low and are ...

To the Editor: The discovery of mutations in the HFE gene in patients with hemochromatosis has made possible earlier or more complete ascertainment of cases of this disease.¹ Diabetes mellitus is one manifestation of hemochromatosis, but in several ...

Hairy-cell leukemia has been the subject of more scientific reports than its rarity might warrant. Many early studies dealt with the morphologic characteristics of hairy cells, the pathological features of involved tissues, tartrate-resistant acid ...

This book contains 18 chapters by well-known specialists from the United States, Europe, and Australia. It covers physiology and pathophysiology, diagnosis (imaging and biochemical markers), therapy (radiation, chemotherapy, and surgical procedures), and ...

Colorectal cancer presents some of the most challenging problems for basic scientists, clinical investigators, and practitioners. It will be important to facilitate an ongoing exchange among these three groups if we are to transform many small steps into ...

Book Review of Blind Eye: How the medical establishment let a doctor get away with murder Book Review, N Engl J Med 2000:342;1057.. The sentence that begins on line 9 of the right-hand column should have read, “As Stewart tells the story, the trail from ...

Intravenous Nesiritide, a Natriuretic Peptide, in the Treatment of Decompensated Congestive Heart Failure Original Article, N Engl J Med 2000:343;246-253.. It should have been stated that the trials were supported by a grant from Scios.