Hypertrophic cardiomyopathy is a genetically determined myocardial disease with a diverse natural history.¹–⁷ Since a subgroup of patients with hypertrophic cardiomyopathy are at high risk for sudden death, there has been considerable interest in risk ...

The risk of venous thromboembolism is five times as high among pregnant women as among nonpregnant women of similar age.¹–³ Estimates of the incidence of pregnancy-associated venous thromboembolism vary from 1 in 1000 to 1 in 2000 deliveries.⁴ ...

The Diabetes Control and Complications Trial¹ (DCCT) was a multicenter clinical trial conducted between 1983 and 1993. It was designed to determine whether intensive therapy with the aim of maintaining blood glucose and glycosylated hemoglobin ...

Clostridium difficile is the leading infectious cause of nosocomial diarrhea in developed countries.¹–⁴ In one study, 21 percent of patients admitted to a general medical ward became colonized with C. difficile and diarrhea developed in 8 percent.⁵ C. ...

Figure 1. A 12-year-old boy with the familial long-QT syndrome had an automatic cardioverter–defibrillator implanted after resuscitation from cardiac arrest. The device was programmed to wait 7.5 seconds before discharging in response to ventricular ...

The proportion of medical school graduates who are women has risen over the past two decades, from 23 percent in 1979 to more than 41 percent in 1997.¹ The representation of women on medical school faculties has also increased steadily during this period.^...

Materials inhaled in the workplace can lead to all the major chronic lung diseases except those due to vascular disease. The physician should consider the possibility of occupational exposure when a working or retired adult presents with unexplained ...

Presentation of Case

A 64-year-old man was admitted to the hospital because of hyperadrenocorticism.

The patient had a history of angina pectoris and had undergone five-vessel coronary-artery bypass surgery nine years before admission. He had long-...

Few problems are harder for physicians and patients alike than having the ability to predict, but not to avert, adverse events; few adverse events are harder to deal with than sudden death in young people. Thus, familial hypertrophic cardiomyopathy ...

Twenty years ago we did not have a problem with thrombophilia as a cause of venous thromboembolism in pregnant and postpartum women, or rather, we did not know we had a problem. The only known major thrombophilic disorder was deficiency of antithrombin, ...

In this issue of the Journal, Nonnemaker reports on a study of the likelihood that women will pursue full-time careers in academic medicine and the likelihood of their advancement to the senior ranks of medical school faculties.¹ She tracked cohorts of ...

Each year thousands of reviewers contribute their expertise to peer review, a process that contributes critically to the quality of the Journal. The editors and the authors of the papers submitted to the Journal are grateful for the help of all our ...

On November 26, the National Labor Relations Board (NLRB) ruled that interns and residents in private hospitals are considered under federal law to be employees, rather than students, and therefore have the right to form unions and engage in collective ...

Medicine has been subjected to more changes in the past several years than in any other period in the history of our profession. Now comes the decision by the National Labor Relations Board (NLRB) to change its long-standing view about the nature of ...

To the Editor: The placebo effect of surgery for the treatment of angina that is mentioned by Lange and Hillis (Sept. 30 issue)¹ in their editorial on transmyocardial laser revascularization deserves elaboration. In the era before direct coronary ...

To the Editor: The report by Andreu et al. (Sept. 30 issue)¹ describes a sporadically occurring mitochondrial myopathy in patients with exercise intolerance that is caused by somatic mutations in the cytochrome b gene of mitochondrial DNA. We performed a ...

To the Editor: Patients infected with the human immunodeficiency virus (HIV) are at risk for malignant non-Hodgkin's lymphoma of B-cell origin.¹ We describe a patient with morphologic features of polymorphic B-cell lymphoproliferation similar to those ...

To the Editor: In their review of nephropathy in pa-tients with type 2 diabetes mellitus (Oct. 7 issue),¹ Ritz and Orth focus on treatment with antihypertensive drugs, mainly angiotensin-converting–enzyme inhibitors. However, other treatments can be ...

To the Editor: Bain provides an overview of idiopathic eosinophilia in her editorial (Oct. 7 issue).¹ However, she does not comment on the fact that eosinophilia may also be a useful marker of adrenal insufficiency. It has been documented that ...

To the Editor: Cardiac angiosarcoma is a rare cancer that accounts for less than 10 percent of all resected primary tumors of the heart; primary tumors of the heart themselves are found in less than 0.3 percent of autopsies.¹–³ Angiosarcomas usually ...

The care of persons with severe and persistent mental disorders is full of uncertainty and controversy. There is a crisis in public health and safety today because of the many thousands of such persons who are homeless or incarcerated and in need of ...

In this book, Dr. Max Fink has made another important contribution to patients and physicians by filling the gap between standard patient-education materials on electroconvulsive treatment, most of which are dated as compared with information available at ...

In 1987 the revised third edition of the Diagnostic and Statistical Manual of Mental Disorders (Washington, D.C.: American Psychiatric Press) distinguished delusional (paranoid) disorder from paranoid schizophrenia. Delusional disorder was defined as a ...

This book presents mainly the experiences of a group of Australian psychiatrists in the early recognition and treatment of psychosis. It addresses a major new issue in psychiatry: prevention of chronic psychiatric illness. At last, serious investigative ...

Looking Back on the Millennium in Medicine Editorial, N Engl J Med 2000:342;42-49.. On page 46, the sentence that begins five lines from the end of the second full paragraph in the left-hand column should have read, “Simultaneously, David Baltimore and ...

Canterbury Cathedral (December 2, 1999;341:1736). The photograph on page 1736 is of York Minster, not Canterbury Cathedral, as the caption reads.