Although dyslipidemia, diabetes, smoking, and hypertension are major risk factors for cardiovascular disease, they do not fully account for the risk. Therefore, other risk factors must be identified in order to reduce mortality and morbidity even further. ...

Oxidative modification of low-density lipoprotein is an important step in the development and progression of atherosclerosis in experimental studies,¹,² and antioxidants such as vitamin E have been shown to slow atherosclerosis.³–⁵ An inverse relation has ...

Wound infections are common and serious complications of surgery. In patients undergoing colorectal surgery, the incidence of wound infection ranges from 9 percent to 27 percent.¹ Surgical-wound infections can prolong hospitalization by 5 to 20 days² and ...

Cataract surgery is the most commonly performed operation in elderly people in developed countries. In the United States, Medicare beneficiaries underwent approximately 1.5 million cataract operations in 1996. Since 1984, in the United States, this ...

Figure 1. A 79-year-old woman presented to the emergency department with a several-hour history of facial swelling (Panel A). The photograph shown in Panel B was taken seven days later. What is the diagnosis?

Parathyroid hormone–related protein was identified in the 1980s as a tumor product that had the ability to activate parathyroid hormone receptors and cause hypercalcemia.¹ Parathyroid hormone–related protein resembles parathyroid hormone not only in terms ...

Ingestion of a harmful substance is among the most common causes of injury to children less than six years of age. Fortunately, in most cases, the ingested agent has minimal or no clinically important toxic effect. Occasionally, however, such ingestion ...

Presentation of Case

A 74-year-old man was admitted to the hospital because of recent, progressive jaundice.

The patient had a long history of hypertension and type 2 diabetes mellitus, both of which were adequately controlled, and of peripheral ...

An important article in this issue of the Journal describes the results of the Heart Outcomes Prevention Evaluation (HOPE) study, which are likely to have important implications for the treatment of cardiovascular disease.¹ The findings indicate that ...

Wound infections are common, serious, and expensive complications after surgery. About 5 percent of all patients who have undergone surgery and as many as 10 to 20 percent of patients who have undergone colorectal surgery have postoperative wound ...

The conclusion of the elegant study by Schein et al.¹ in this issue of the Journal seems obvious from their data: we should stop ordering routine preoperative laboratory tests for patients before cataract operations or other relatively simple surgical ...

A byproduct of the aging of the population has been a dramatic rise in the rate of Alzheimer's disease and other types of dementia. A conservative estimate is that there are currently 4 million people in the United States with dementia.¹ In the final ...

To the Editor: Leitzmann et al. (Sept. 9 issue)¹ found that in women, recreational physical activity is associated with a decreased risk of cholecystectomy. Drawing firm conclusions about gallstone disease from cholecystectomy rates is problematic, since ...

To the Editor: De Stefano and colleagues (Sept. 9 issue)¹ reported the results of their retrospective analysis of the risk of recurrent deep venous thrombosis in patients with deep venous thrombosis who were heterozygous for both factor V Leiden and the ...

To the Editor: Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone are known side effects of selective serotonin-reuptake inhibitors such as fluoxetine and sertraline¹,² and the inhibitor of serotonin and norepinephrine ...

To the Editor: Kudenchuk and colleagues (Sept. 16 issue)¹ report that in patients with refractory out-of-hospital cardiac arrest, a single dose of intravenous amiodarone improves survival to hospital admission (44 percent of patients in the amiodarone ...

To the Editor: Pizzo, in his review entitled “Fever in Immunocompromised Patients” (Sept. 16 issue),¹ states that immediate postoperative care for recipients of bone marrow transplants should be similar to the treatment of high-risk patients with cancer ...

To the Editor: Hooper (Sept. 16 issue)¹ reports interesting results of hot-tub therapy for patients with type 2 diabetes mellitus. In addition to there being potential adverse effects to the cardiovascular system, a word of caution is warranted regarding ...

To the Editor: In Neisseria meningitidis, the horizontal transfer of siaD genes encoding polysialyltransferases has been shown to result in capsular serogroup switching in vitro.¹ The presence of closely related clones with different serogroups suggests ...

According to the United Nations Human Development Report published in 1996, the 358 richest persons on earth control assets equivalent to the annual income of 45 percent of the world's population. In the United States, the top 1 percent of income earners ...

Academic underachievement and misbehavior in school, either real or perceived, are common reasons for the referral of children for evaluation, diagnosis, and treatment of learning disorders. Although there are many potential causes for these problems in ...

Youth Violence: Prevention, Intervention, and Social Policy expands the traditional criminologic view of youth violence to include some perspectives on prevention but, for the most part, stays rather close to conventional views of adolescent delinquency.

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Students' Knowledge of and Attitudes about Female Circumcision in Egypt Correspondence, N Engl J Med 1999:341;1552-1553.. On page 1553, in Table 1, the wrong values appear in the first four columns next to the entry “You would object if a family member ...

Priming with Human Chorionic Gonadotropin before Retrieval of Immature Oocytes in Women with Infertility Due to the Polycystic Ovary Syndrome Correspondence, N Engl J Med 1999:341;1624-1626.. On page 1626, in Table 1, the last entry in the first column ...