Although bystander-initiated cardiopulmonary resuscitation (CPR) has been associated with an increase of 50 percent or more in survival after out-of-hospital cardiac arrest, and despite extensive training of citizens in CPR techniques,¹,² approximately ...

The administration of moderately emetogenic drugs such as cyclophosphamide, doxorubicin, epirubicin, and carboplatin often causes nausea and vomiting within 24 hours after the start of chemotherapy (acute emesis) or two to five days later (delayed emesis)...

Parkinson's disease is one of the most frequent neurodegenerative disorders, with a prevalence of 1 to 2 percent among persons older than 65 years of age.¹ It is characterized by resting tremor, rigidity, and bradykinesia, all of which respond well to ...

The hypereosinophilic syndrome comprises various idiopathic myeloproliferative disorders with sustained eosinophilia and damage to the heart, lungs, skin, and other organs by infiltrating eosinophils.¹ A single mechanism for this syndrome has not been ...

Figure 1. An 86-year-old woman with a several-year history of recurrent urinary tract infections presented with vague abdominal symptoms. Physical examination disclosed right-flank tenderness. She had an Escherichia coli urinary tract infection. A ...

Many studies have documented an inverse relation between the rate of mortality from cardiovascular causes and the number of elective reperfusion procedures performed by individual practitioners or hospitals. Lower mortality rates have been associated with ...

Hyponatremia is defined as a decrease in the serum sodium concentration to a level below 136 mmol per liter. Whereas hypernatremia always denotes hypertonicity, hyponatremia can be associated with low, normal, or high tonicity.¹,² Effective osmolality or ...

Presentation of Case

A 53-year-old woman was admitted to the hospital because of swelling of the right breast and bilateral lymphadenopathy.

The patient had been well until five months earlier, when severe bronchitis developed. She received trimethoprim–...

The major determinants of survival after witnessed out-of-hospital cardiac arrest due to ventricular fibrillation include whether a bystander initiates cardiopulmonary resuscitation (CPR) and how quickly defibrillation is accomplished.

The now-classic ...

The Kigezi International School of Medicine of Uganda and the Ross University School of Medicine in Dominica have recently announced their intentions to establish campuses in the United States. Ross University expects to open its campus in Casper, Wyoming,...

To the Editor: Gryfe et al. (Jan. 13 issue)¹ report that microsatellite instability in colorectal cancer is independently predictive of a favorable outcome. We have some concern about this conclusion, since the tumors with microsatellite instability were ...

To the Editor: Jensen et al. (Jan. 13 issue)¹ report on 10 patients who had stigmata of diverticular hemorrhage and were treated endoscopically. None of the 10 had early or late episodes of recurrent bleeding (median follow-up period, 30 months). Unless ...

To the Editor: X-linked agammaglobulinemia is characterized by a profound defect in the production of antibodies of all isotypes; the defect is related to impaired B-lymphocyte differentiation resulting from mutations in the gene for B tyrosine kinase.¹ ...

To the Editor: In a well-designed and informative study, Miller and colleagues (Jan. 13 issue)¹ demonstrated that among children with sickle cell disease who were younger than two years of age, dactylitis, severe anemia, or an elevated leukocyte count ...

To the Editor: Greif and colleagues (Jan. 20 issue)¹ report that the administration of supplemental oxygen during the perioperative period reduced the frequency of surgical-wound infections among patients undergoing colorectal surgery. However, by ...

To the Editor: Pyomyositis is very uncommon in the United States, and only about 100 cases have been reported in North America during the past 20 years.¹ We describe a 48-year-old, homeless intravenous drug user in whom acute staphylococcal endocarditis ...

What makes a book great? Essentially, a great subject and a great writer combined. Finger's book is in that league. The author, a psychologist and a historian of neuroscience, has chosen a biographical approach to explain how our knowledge of brain ...

Evolution is still a questionable concept in some quarters. It seems that it has little to do with the practice of medicine. Indeed, I know a number of successful practitioners and professors of medicine who do not “believe” in evolution. In this book, a ...

I recently picked up a copy of the two-volume, multiauthored American Handbook of Psychiatry (Silvano Arieti, ed. New York, Basic Books), published in 1959. Neurobiology was represented only in a few sections, notably in one entitled Organic Conditions, ...

Amyotrophic lateral sclerosis is a progressive, paralyzing illness that is invariably fatal. It has been neglected until recently because there was only a poor understanding of pathogenesis and no treatment. Physicians often experience a sense of ...

Neuromuscular diseases comprise a large number of clinically and etiologically diverse disorders affecting the muscle, the neuromuscular junction, the nerve, and the motor neuron. Among them are genetic, autoimmune, toxic, viral, and metabolic diseases. ...

Retroperitoneal Hemorrhage Images in Clinical Medicine, N Engl J Med 2000:342;702.. The partial-thromboplastin times in the legend should have been activated partial-thromboplastin times.

Case Records of the Massachusetts General Hospital (Case 9-2000) Case Records of the Massachusetts General Hospital, N Engl J Med 2000:342;875-883.. On page 875, Figure 1 should have been identified as a lateral radiograph, not an anteroposterior ...