Screening studies in the United States, Europe, and Australia have shown that a substantial proportion of the adult population has mild-to-moderate sleep-disordered breathing, a condition characterized by repeated episodes of apnea and hypopnea during ...

Permanent cardiac-pacemaker therapy is widely recognized as beneficial in the treatment of various types of symptomatic bradycardia. Early pacemakers were capable of pacing only one chamber of the heart, usually the right ventricle. More recently, dual-...

Dietary guidelines for patients with diabetes mellitus were revised by the American Diabetes Association (ADA) earlier this year.¹ The ADA recommends that the composition of the diet be individualized on the basis of a nutritional assessment and the ...

Pneumonia remains a leading cause of death among children throughout the world. Each year, an estimated 4 million children, primarily in developing countries, die from pneumonia.¹ Efforts to reduce the rate of mortality from childhood pneumonia in ...

Figure 1. A 42-year-old woman was evaluated because of excessive daytime sleepiness and habitual heavy snoring. A nocturnal polysomnogram revealed no evidence of obstructive or central sleep apnea, but it did show frequent periods of snoring and augmented ...

In the United States, the proportion of the population made up of persons 65 years of age or older is projected to increase from 13 percent of the population in 2000 to 20 percent by 2030 because of the aging of the baby-boom generation and increased ...

Soon after the acquired immunodeficiency syndrome (AIDS) was first described in 1981,¹–⁴ it became clear that opportunistic infections occurred with remarkable frequency and caused substantial morbidity and mortality among patients with AIDS. On the basis ...

Presentation of Case

A 60-year-old man was admitted to the hospital because of pneumonia.

The patient had been well until 10 days earlier, when exertional dyspnea developed, with chills, fever, and night sweats. Two days later, his temperature rose to 40°...

In this issue, we introduce a new feature, called “This Week in the New England Journal of Medicine.” It will consist of very brief and readable summaries of our research articles for the benefit of general readers and those just dipping into the Journal. ...

In the past decade, many new drugs have become available for patients with diabetes mellitus. The sulfonylurea drugs and metformin have been joined by disaccharidase inhibitors, meglitinides, and thiazolidinediones. Several new insulin preparations have ...

In the early 1990s two randomized clinical trials showed that folic acid, or multivitamins containing folic acid, could substantially reduce a woman's risk of bearing a child with a neural-tube defect, provided that the vitamins were taken before ...

To the Editor: Grines et al. (Dec. 23 issue)¹ found that the benefit of coronary stenting after myocardial infarction was attributable only to the marked decrease in the rate of revascularization at six months. However, the unblinded study design may ...

To the Editor: Given the strong relation between the volume of procedures and outcomes in interventional cardiology, the results reported by Rankin et al. (Dec. 23 issue)¹ may not completely reflect current population outcomes.²,³ The use of a ...

To the Editor: Sagristà-Sauleda et al. (Dec. 30 issue),¹ in their report on the long-term follow-up of patients with idiopathic chronic pericardial effusion, conclude that pericardiectomy should be considered whenever a large effusion recurs after ...

To the Editor: Pheochromocytomas are tumors of chromaffin tissue that may secrete catecholamines continuously or intermittently, thereby causing sustained or paroxysmal hypertension, respectively. After removal of the primary tumor, 6 to 23 percent of ...

To the Editor: The article by Kyriacou et al. (Dec. 16 issue)¹ on risk factors for injury to women from domestic violence reports on the characteristics of relationships and behavior that are associated with domestic violence. The partners of women at ...

To the Editor: I was dismayed by Dr. Grumbach's comment, in his editorial on primary care in the United States (Dec. 23 issue),¹ that primary care physicians are “the type of physician everyone really needs, unless of course the person is actually ill, ...

To the Editor: Edlow and Caplan (Jan. 6 issue)¹ present an excellent review of the pitfalls encountered in the diagnosis of subarachnoid hemorrhage. However, after stating that the initial diagnostic study should be noncontrast computed tomography (CT) ...

What is the relation among anatomy, sexual identity, and sexual practices? The authors of Intersex in the Age of Ethics argue that an ethical clinical response to intersexuality (i.e., the intermingling, in varying degrees, of male and female sex ...

A variety of conditions may cause an infant to have ambiguous genitalia. The treatment of choice is a topic of hot debate among professionals and, more recently, among support groups of adults born with such intersexual conditions. One issue concerns the ...

Albert Jonsen, a distinguished theoretician and practitioner of bioethics, has written what is essentially a prehistory of the field. He begins with the Greek and Roman period (from the fifth century b.c.e. to the third century c.e.), moves on to medieval ...

This book is a portrait of genetic screening that shows how the culture and history of a country determine the manner in which the science of genetics is viewed and the availability of particular clinical genetic services. At one extreme, in Germany, ...

Case Records of the Massachusetts General Hospital (Case 1-2000) Case Records of the Massachusetts General Hospital, N Engl J Med 2000:342;115-122.. On page 116, in Figure 1, the arrow is misplaced. The corrected figure and its legend are reprinted below.