Type 2 diabetes mellitus affects more than 7 million Americans,¹ leading annually to 2.8 million hospitalizations,² more than 300,000 deaths,³ and more than $100 billion in total costs.⁴ Improved glycemic control is known to slow the onset and progression ...

Atrial fibrillation is the most common arrhythmia requiring treatment and affects 5 percent of people older than 65 years.¹,² The number of hospital admissions for atrial fibrillation in the United States more than doubled from 1984 to 1994, from 111,000 ...

In sub-Saharan Africa, the predominant mode of transmission of human immunodeficiency virus type 1 (HIV-1) is through heterosexual contact, and the rate of transmission by this means is increasing throughout Asia and in many industrialized countries.¹,² A ...

Patients infected with human immunodeficiency virus type 1 (HIV-1) are susceptible to neoplasms, including Kaposi's sarcoma, non-Hodgkin's lymphoma, and anal and cervical carcinoma.¹–⁵ Some of these neoplasms have been associated with oncogenic infectious ...

Figure 1. A 46-year-old woman had an enlarging, tender, draining nodule on the upper arm. Prior treatment consisting of hot compresses and a course of oral antibiotics had had no effect. The patient had no other symptoms or findings, and the results of ...

The management of acute pain and anxiety in children undergoing therapeutic and diagnostic procedures outside the operating room has developed substantially in the past 15 years. The widespread availability of noninvasive monitoring, short-acting opioids ...

Termination of pregnancy has been practiced since antiquity. Although many societies accept this practice, some reject it, and it is sometimes even considered a crime. The most widely used methods for terminating pregnancy early in the first trimester are ...

Presentation of Case

A 63-year-old man was admitted to the hospital in early July because of rapidly progressive changes in behavior and ataxia.

The patient had been well until 13 days earlier, when he began to have bifrontal headaches, with low-grade ...

Most people agree that investigators assume some responsibility for their human subjects, but how much? And does it matter where the research is carried out? These issues are raised by the report by Quinn et al. elsewhere in this issue of the Journal ¹ ...

Although thiazide diuretics and beta-blockers are often used as first-line therapy in patients with hypertension, including those with diabetes mellitus,¹ the possibility that these drugs may promote glucose intolerance remains a concern.²–¹⁰ Short-term ...

When human immunodeficiency virus type 1 (HIV-1) was identified as the cause of AIDS more than 15 years ago, it seemed possible that an end to the epidemic would follow. However, the control of communicable diseases requires far more than the ...

To the Editor: Ziesche et al. (Oct. 21 issue)¹ report the findings of a preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. Given that there is no successful medical ...

To the Editor: Singhal et al. (Nov. 18 issue)¹ report the results of a phase 2 study of thalidomide for the treatment of multiple myeloma and conclude that the drug can reduce serum and urine levels of paraprotein in some patients with refractory ...

To the Editor: We take issue with some of the recommendations made by Utiger in his editorial on the treatment of primary hyperparathyroidism (Oct. 21 issue).¹ Measurement of serum calcium was advocated, with no mention of correction for abnormal serum ...

To the Editor: Lanza et al. (Sept. 30 issue)¹ described a case of acute myocardial infarction due to a coronary embolus arising from a left ventricular thrombus. We report a case of myocardial infarction that was fatal, despite fibrinolytic therapy, and ...

To the Editor: We are interested in the solution proposed by Marquis (Aug. 26 issue)¹ to the ethical dilemma posed by conflicting obligations to provide patients with a treatment recommendation and to invite them to join a randomized clinical trial. The ...

To the Editor: In his article on support for academic medical centers, Iglehart (July 22 issue)¹ seems to describe the issue of variation in Medicare's payments for residency training as a conflict among states, with New York defending the current policy ...

To the Editor: A 68-year-old man presented with a three-year history of trembling of the legs. The tremor began immediately after he stood and subsided when he began walking. His medical history was irrelevant to this problem. Neurologic examination ...

In French DNA, anthropologist Paul Rabinow makes the case that the “basic understanding and practices of `bare life' have been altered” by the revolution in genetics. Seen as essential, irreducible, and fundamental, DNA can stand in for the whole person (...

Prion-related diseases constitute a unique category of illnesses that can be inherited, infectious, or sporadic. The ongoing saga of efforts to unravel the pathogenesis of prion diseases is one of the most fascinating accounts in recent medical science. ...

This book compiles the efforts of 41 contributing authors (many of whom are leaders in the field) to address most of the major issues in the prevention of stroke. With its strong emphasis on adequately powered, randomized, controlled, multicenter trials, ...

Fifty years ago, in his textbook Heart Disease (4th ed. New York, Macmillan, 1951), Paul Dudley White, one of the most recognized cardiovascular physicians of his day, reflected on the progress made in cardiovascular care during the previous century and ...

Looking Back on the Millennium in Medicine Editorial, N Engl J Med 2000:342;42-49.. On page 46, in line 18 of the left-hand column, Oswald Theodore Avery's name was given incorrectly as Thomas Avery. We regret the error.

Congenital Heart Disease in Adults (Second of Two Parts) Review Article, N Engl J Med 2000:342;334-342.. On page 340, the sentence that begins on line 2 of the right-hand column should have read, “Pulmonary vasodilators — such as oxygen, inhaled nitric ...