During the treatment of cancer, the appearance of fever with neutropenia is the first manifestation of a potentially life-threatening bacterial infection.¹ Prompt hospitalization of patients with cancer who have fever and neutropenia and initiation of ...

Combinations of β-lactams and aminoglycosides or monotherapy with ceftazidime or a carbapenem has been recommended as standard empirical therapy for fever in patients who have granulocytopenia as a result of cancer chemotherapy.¹,² A number of prognostic ...

Since the introduction of balloon angioplasty more than 20 years ago, two therapies have been demonstrated to improve outcomes after the procedure and have been widely adopted into clinical practice. Inhibition of platelet aggregation by blockade of the ...

Perinatal asphyxia is an important cause of neonatal mortality and of subsequent neurologic disabilities among the infants who survive.¹–³ Newborn infants who sustain an acute intrapartum hypoxic–ischemic insult of sufficient magnitude to result in long-...

Figure 1. A 19-year-old man presented with a five-year history of a gradually increasing mass on the lateral aspect of his right knee. He first noted this mass after receiving a direct blow to the area while playing ice hockey. Magnetic resonance imaging ...

Clinicians use Current Procedural Terminology ¹ visit codes to bill Medicare and other payers for services involving the evaluation of patients and the management of their care. The existing Current Procedural Terminology guidelines for coding visits and ...

Common malignant tumors of the musculoskeletal system in children, adolescents, and young adults (<30 years old) include rhabdomyosarcoma, osteosarcoma, and Ewing's sarcoma. Together they constitute about 10 percent of newly diagnosed cancers in children, ...

Presentation of Case

A 10-month-old girl was admitted to the hospital because of fever and a rash.

She had apparently been well until one month earlier, when she was examined because of fever and an erythematous rash suggestive of scarlet fever. A throat ...

The treatment of fever and neutropenia has evolved with the development of both new antimicrobial drugs and new strategies for using them. More than three decades ago, Bodey and colleagues identified the association between neutropenia and serious ...

Neonatal brain injury due to intrapartum asphyxia is an important cause of cerebral palsy, mental retardation, and epilepsy.¹ Despite advances in perinatal care over the past three decades, the incidence of cerebral palsy attributed to birth asphyxia has ...

Sometime in 1998, as ably chronicled by Brett,¹ a long-simmering disagreement over an arcane administrative construct — documentation guidelines for physicians to use in coding evaluation and management services billed to Medicare — was transformed into a ...

To the Editor: In their study of the prevention of delirium in hospitalized older patients (March 4 issue),¹ Inouye et al. provide data on the cumulative incidence of delirium as a function of the length of hospitalization that suggest that prolonged ...

To the Editor: Mortensen et al. (Feb. 25 issue)¹ acknowledge that a family history of schizophrenia is the best-established risk factor for the disorder but suggest that environmental factors, including the place and season of birth, are major ...

To the Editor: Tuomilehto and colleagues present a post hoc analysis (March 4 issue)¹ of a trial of nitrendipine-based treatment for older patients with isolated systolic hypertension.² The authors evaluated the outcome in patients with diabetes, a group ...

To the Editor: Constrictive pericarditis is characterized by a thickened and adherent pericardium that restricts diastolic filling of the heart.¹ Although many diagnostic criteria for constrictive pericarditis have been proposed, not all cases ...

To the Editor: It is well established that immunosuppression after organ transplantation carries an increased risk of certain malignant tumors. Of these tumors, those of the skin and lip and lymphomas are the most common.¹ We report a carcinoma of the ...

To the Editor: Grimbacher et al. (March 4 issue)¹ described in detail 30 patients with hyper-IgE syndrome. Recently, a 29-year-old Italian woman was admitted to our hospital because of acute back pain due to spontaneous fracture of the L3 vertebral body. ...

To the Editor: The conclusion by Muennig et al. (March 11 issue)¹ that empirical treatment of all U.S. immigrants at risk for parasitosis would result in a net health benefit is driven by the assumption in their decision-analysis model that albendazole ...

To the Editor: A 10-year-old boy was admitted to the hospital with crampy epigastric pain after eating. He mentioned swallowing a small object. Gastroscopy revealed a toy flashlight (2.5 cm in diameter) emblazoned with a cartoon character (Figure 1). The ...

The 100-year effort by black psychiatrists to become important contributors to mainstream American psychiatry began with the graduation of Solomon Carter Fuller from Boston University School of Medicine in 1897. The history of that effort is presented in ...

The topic of Gilles de la Tourette's syndrome, or Tourette's syndrome, continues to lure those who are fascinated by the exotic. Although tic disorders are common among children and even full-blown Tourette's syndrome is hardly rare, the bizarre and ...

This book presents a powerful case for the primacy of German medical research, including research on cancer and epidemiologic studies of the link between tobacco and cancer, during the Nazi period. The book is very well written and makes an important ...

A Comparison of Multimodal Therapy and Surgery for Esophageal Adenocarcinoma Original Article, N Engl J Med 1996:335;462-467.. On page 466, the phrase “but Excluding In-Hospital Deaths” should have been added to the titles of each of the figures.

Increased Frequency of Genetic Thrombophilia in Women with Complications of Pregnancy Original Article, N Engl J Med 1999:340;9-13.. On page 9, on lines 12 and 13, factor V Leiden should have been identified as “the mutation of guanine to adenine at ...