Percutaneous transluminal coronary angioplasty for primary treatment after acute myocardial infarction has been demonstrated to be superior to thrombolytic therapy with regard to the restoration of normal coronary blood flow¹ and is associated with lower ...

The technique of percutaneous revascularization for obstructive coronary disease has been evolving since it was pioneered by Grüntzig et al. in 1977.¹ The introduction² and refinement³–⁵ of techniques for the implantation of coronary stents coupled with ...

Recombinant humanized monoclonal antibody (rhuMAb-E25) was developed by immunizing mice with human IgE. A monoclonal antibody was selected that recognizes IgE at the same site as the high-affinity receptor for IgE (Fc εRI).¹ This antibody forms complexes ...

Many women with ectopic pregnancies are now treated with methotrexate instead of surgery. Although the exact mechanism of action is unknown, methotrexate is believed to cause either resorption or tubal abortion of the conceptus. Among the treatment ...

Figure 1. A plain abdominal film (Panel A) revealed diffuse renal calcification in a 22-year-old woman with end-stage renal disease. After two months of regular hemodialysis, skin bullae and livedo reticularis appeared on her legs, and loss of central ...

Strategies to control medical costs and improve the quality of care are often designed to change the way that physicians, particularly primary care physicians, practice medicine. Managed-care plans and physician groups have established a variety of ...

Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe²⁺) and ferrous (Fe³⁺) forms. This capability makes it a useful component of cytochromes, oxygen-binding molecules (i.e., hemoglobin and myoglobin), and many ...

Presentation of Case

A 74-year-old woman was admitted to the hospital because of diarrhea and fever followed by multiple cranial-nerve palsies.

She had a one-week history of fever (temperature, 40°C), watery diarrhea, nausea, abdominal pain, weakness, and ...

Since the introduction of coronary stents into clinical practice in the early 1990s, the number of stent implantations has increased so rapidly that stents are currently used in 60 to 70 percent of all percutaneous interventional procedures.¹ Although ...

Over the past 10 years there have been striking improvements in the treatment of asthma, largely as a result of the earlier and more widespread use of inhaled corticosteroids. The development of new treatments for asthma has proved difficult, although ...

Until relatively recently, primary care was a neglected facet of the modern U.S. health care system, obscured by the shadows of the citadels of specialty medicine. These lofty icons of American culture were richly furnished with the latest technology that ...

Plasma lipoproteins transport fats (cholesterol and triglyceride) and hence have a key role in atherosclerotic cardiovascular disease. Low-density lipoprotein (LDL) cholesterol promotes atherogenesis, and high-density lipoprotein (HDL) cholesterol ...

To the Editor: Haddow et al. (Aug. 19 issue)¹ suggest that screening pregnant women for hypothyroidism by measuring serum thyrotropin may be worthwhile and that treating women with serum thyrotropin concentrations at or above the 98th percentile could ...

To the Editor: In their otherwise thoughtful and informative article, Drolet and colleagues (July 15 issue)¹ dismiss intralesional corticosteroid injection in the treatment of juvenile periocular hemangiomas as “contraindicated, since it is fraught with ...

To the Editor: Hemangiomas and structural malformations of the vasculature are distinct entities that have different biologic features and require different therapeutic approaches.¹ This distinction was nicely stated in the review of hemangiomas in ...

To the Editor: Common causes of hepatic hematoma include trauma and rupture of a hepatic tumor (adenoma or hepatoma). We report a case of hepatic hematoma that developed after a deep body massage.

A 39-year-old woman who had no history of serious ...

To the Editor: In his review of drug treatment for lipid disorders (Aug. 12 issue),¹ Dr. Knopp notes that dietary intervention is an important first step in the treatment of patients with hyperlipidemia. We would like to remind readers not to overlook ...

To the Editor: I have read the article by Schwartz et al. (July 22 issue),¹ and I am convinced by their arguments that the article by Schulman et al. in the February 25 issue² did not present the best description of the data. I further agree that the ...

Thyroid cancer, the most common type of endocrine tumor, has been the subject of intense research and considerable attention in the past decade. At least two reasons may explain why the scientific community has taken a renewed interest in this cancer.

The ...

A little over 100 years ago, Rehn made the seminal observation that there was a high incidence of bladder cancer among workers exposed to aniline dyes. The subsequent identification of the carcinogens used in the manufacture of these dyes led to the first ...

I review this book as a urologist who interacts with primary care physicians on a daily basis, but I acknowledge that I have definite opinions about what these practitioners should know in caring for patients with urologic disease. I also recognize that ...

The Effects of Vancomycin and β-Lactam Antibiotics on Vancomycin-Resistant Staphylococcus aureus Correspondence, N Engl J Med 1999:341;1624.. On page 1624, the last sentence of the legend to Figure 1 should have read, “The arrow in Panel E indicates the ...

Part 1 of this article discussed the career paths of managed-care medical directors in both HMOs and provider organizations and described their work in the area of utilization management. In this second part, we resume the description of the work of ...