The advent of new antiretroviral agents, most notably protease inhibitors, has generated new hope in the fight against human immunodeficiency virus type 1 (HIV-1).¹ The use of a combination of a protease inhibitor plus two nucleoside reverse-transcriptase ...

A major objective of antiretroviral therapy is to reduce the amount of human immunodeficiency virus type 1 (HIV-1) RNA in plasma to undetectable levels, because these levels appear to reflect the degree of viral replication in the body. Even low levels of ...

Despite recent decreases in the rates of death from cardiovascular disease, mortality after discharge from the hospital remains high among survivors of acute myocardial infarction who have substantial left ventricular dysfunction. Among such persons, the ...

Figure 1. A 60-year-old man with diabetes mellitus and advanced cirrhosis underwent orthotopic liver transplantation that was complicated by an intraoperative myocardial infarction. His immunosuppressive regimen included tacrolimus and methylprednisolone, ...

Domestic violence is the most com-mon cause of nonfatal injury to women in the United States.¹–³ Victims are pushed, punched, kicked, strangled, and assaulted with various weapons with the intent of causing pain, injury, and emotional distress.⁴ The ...

Rates of homicide are nearly four times as high among black American women as they are among white American women, yet little is known about the nature or causes of violence perpetrated against black American women.¹–⁵ Most studies of violence against ...

Contrary to common belief, the association between diabetes mellitus and increased susceptibility to infection in general is not supported by strong evidence.¹,² However, many specific infections are more common in diabetic patients, and some occur almost ...

Presentation of Case

A 62-year-old woman was admitted to the hospital because of a foot infection.

The patient's medical history included hypertension, hyperlipoproteinemia, and mild chronic renal failure, with a base-line creatinine level of 2 mg per ...

Five years ago, the citizens of Oregon voted by a narrow margin to legalize physician-assisted suicide for certain terminally ill patients. There followed a variety of efforts to nullify the decision, which culminated in a second referendum in 1997. This ...

Fifteen drugs are currently available for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection, all of which target the virally encoded transcriptase or protease enzymes. Under development is a second generation of ...

This issue of the Journal includes two reports on risk factors for violent injuries to women. The findings of Kyriacou et al.¹ and Grisso et al.,² from case–control studies in hospital emergency rooms, are not surprising. But the public-policy ...

To the Editor: Vaccarino et al. (July 22 issue)¹ show that younger women, but not older women, have higher rates of death during hospitalization after acute myocardial infarction than men of the same age. Potential reasons for their findings include ...

To the Editor: Wald et al. (Aug. 12 issue)¹ describe a protocol for screening for Down's syndrome that is based on tests performed during both the first and second trimesters of pregnancy. However, their estimates are based on data from multiple studies, ...

To the Editor: In their report of the transfer of an aggressive natural-killer-cell lymphoma from a mother to her fetus, Catlin et al. (July 8 issue)¹ suggest that the maternal lymphoma was not rejected by the infant because of the immaturity of the ...

To the Editor: In their excellent review of disseminated intravascular coagulation, Drs. Levi and ten Cate (Aug. 19 issue)¹ suggest that a test for fibrin-degradation products be used in the diagnosis. They do not recommend that the d-dimer assay should ...

To the Editor: Experimental studies suggest that metabolic acidosis impairs the contractile function of the heart, but whether this occurs in humans is uncertain.¹,² During a six-month period, we measured fractional shortening of the left ventricle ...

Each year, thousands of bright, energetic, highly motivated students are admitted to medical school. I have often pondered how much formal teaching such bright students really need to become excellent doctors. How much does the curriculum matter? How ...

Can managed care improve health care for the tens of millions of Americans living in our inner cities? The authors of this book believe that it can. Although they describe thoroughly the ways that managed care has thus far failed to realize this promise, ...

Amid the embarrassments of Monicamania and of multiple public mea culpas, the past few years have not been exemplary ones for American journalism. This fact makes the triumph of The Plutonium Files all the sweeter, because this superlative book is a ...

Chest Pain with a Surprising Course Clinical Problem-Solving, N Engl J Med 1999:341;1134-1138.. On page 1137, in the legend to Figure 2, the magnification for Panel A should have been ×100, and that for Panel B ×1000, not ×10 and ×40, as printed.

During the past two decades, a new breed of physician leaders has emerged. These leaders — the medical directors of health plans, medical groups, and independent practice associations (IPAs) — exercise substantial influence over medical practice. Yet ...