Somatization is a frequently cited feature of depression in patients seen by primary care physicians.¹–³ Some studies suggest that patients in non-Western cultures or developing countries report somatic symptoms and deny psychological symptoms more ...

Yearly immunization with inactivated vaccines is the main strategy for the prevention of influenza.¹ When substantial antigenic drift occurs after the formulation of a vaccine — as happened, for instance, during the 1997–1998 season, when the A/Sydney/5/...

The outcome of subarachnoid hemorrhage from a ruptured aneurysm remains poor, with a case fatality rate of 50 percent and a rate of functional dependence of 20 percent.¹ The risk of subarachnoid hemorrhage among first-degree relatives (parents, siblings, ...

Although attention has been given to the prognostic implications of changes in heart rate during exercise,¹–³ the prognostic value of the rate of decline in heart rate after the cessation of exercise has not been well characterized. The rise in heart rate ...

Figure 1. A 72-year-old man underwent follow-up colonoscopy after the removal of multiple tubulovillous polyps. Severe diverticulosis was the only finding. Three diverticula were seen adjacent to the larger lumen of the bowel.

Universal health care systems have been organized in most industrialized nations with a view to ensuring equitable access to medical services and improving health status for all citizens. Canada's federal–provincial Medicare plan covers all medically ...

In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually.¹ Biliary tract cancer is the second most common primary hepatobiliary cancer, after hepatocellular cancer. Approximately 7500 new cases of ...

Presentation of Case

A 57-year-old woman was admitted to the hospital because of a pulmonary mass in the left lower lobe.

The patient had been well until seven weeks earlier, when a respiratory infection developed, with chilliness and a cough productive ...

Influenza is a highly contagious acute respiratory disease of global importance. It is also a model of emerging and reemerging infectious diseases,¹ for two reasons. First, annual epidemics of influenza are caused by viruses that have evolved sufficiently ...

In May 1999, Dr. Leandro Pasos, an orthopedic surgeon, was accused of unprofessional conduct by the Washington State Health Department for prescribing sildenafil (Viagra) over the Internet to patients he had neither seen nor examined.¹,² This case was one ...

To the Editor: Socié et al. (July 1 issue)¹ reported on the long-term survival of patients who have undergone allogeneic bone marrow transplantation and the rate of death more than two years after transplantation. They provided information on the ...

To the Editor: In their article on hydrogenated fats and serum cholesterol levels, Lichtenstein et al. (June 24 issue)¹ apparently did not consider variations in the ratio of polyunsaturated to saturated fatty acids (P:S) in the six experimental diets. ...

To the Editor: In their article, Wolfe et al. (June 17 issue)¹ stated that the number of deaths associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) in the United States every year is almost identical to that associated with AIDS. This ...

To the Editor: Spinal epidural lipomatosis, or excess epidural fat, can compress nerve roots or the spinal cord. It occurs in patients with morbid obesity, hypothyroidism, and exogenous Cushing's syndrome¹ but rarely in those with endogenous Cushing's ...

To the Editor: I am the 29-year-old patient who was discussed in the letter “Parkinsonism after Taking Ecstasy” (May 6 issue).¹ I believe it is important to clear up some incorrect statements made by the doctors who wrote the letter.

In their letter, the ...

With the discovery of insulin in 1922, the study of diabetes was changed forever. From that time forward, it has been difficult to discuss the pathophysiology of diabetes without in some way referring to this critical metabolic hormone, which is a life-...

Preeclampsia remains a lethal enigma of pregnancy. Encompassing more than just hypertension, it can include abnormalities of platelet behavior and clotting mechanisms and of endothelial, hepatic, and renal function. The first edition of Leon Chesley's ...

With the increasing focus of both vascular medicine and vascular surgery on vascular-wall biology, students of aortic disease have come to expect that books on the subject will incorporate discussions of nitric oxide, endothelin, shear stress, ...

Public awareness of the use of restraints in medicine has been greatly heightened by a five-part investigative series on physical restraints in psychiatric hospitals by the Hartford Courant and reaction to it by Connecticut's U.S. senators, Joseph ...

Molecular Basis of the Neurodegenerative Disorders Review Article, N Engl J Med 1999:340;1970-1980.. On page 1971, in Table 1, the sixth entry in the column headed “Neuropathological Features” incorrectly states that there are Lewy bodies in pigmented ...

The β-Thalassemias Review Article, N Engl J Med 1999:341;99-109.. On page 101, in Figure 2, the 5' and 3' untranslated sequences (leader and trailer sequences) were incorrectly labeled as introns.