Spontaneous abortion is the most common adverse outcome of pregnancy.¹ Heralded by vaginal bleeding, it is associated with considerable pain, suffering, and medical costs. Little is known about the influences of lifestyle on spontaneous abortion, although ...

Exercise electrocardiography is frequently used as a diagnostic test for coronary artery disease. Previous studies correlating exercise-induced ST-segment depression with findings on coronary arteriography and thallium-201 scintigraphy have provided ...

Lymphedema is an important long-term complication of local and regional therapy in women with breast cancer. It can result in cosmetic deformity, loss of functional ability, physical discomfort, and recurrent episodes of cellulitis and lymphangitis. It is ...

Cisplatin and carboplatin are among the most important drugs introduced during the past three decades for the treatment of cancer. These derivatives of platinum have a central role in chemotherapy for patients with cancers of the ovary, testis, bladder, ...

Figure 1. A right axillary mass was palpated by a 62-year-old woman while she was exercising. Surgical biopsy revealed adenocarcinoma, suggestive of metastatic breast cancer. The results of physical examination and mammography of the right breast were ...

In 1992, New York City reported 3811 cases of tuberculosis, nearly three times the number of cases reported 15 years before.¹ As part of a comprehensive response, the New York City Department of Health expanded services for patients with tuberculosis and ...

Tuberculosis remains an important problem in patients with human immunodeficiency virus (HIV) infection in the United States, with an estimated 6000 to 9000 new cases annually.¹ The case rates are extraordinarily high among indigent patients and substance ...

Stage

A 50-year-old man with alcoholism was brought to the emergency department by his wife because of altered mental status. According to her, the patient had been drinking his usual case of beer (approximately 9 liters) each night until 36 hours earlier,...

In 1991 the Senate Committee on Appropriations approached the National Institute of Child Health and Human Development with a request and an offer. The request was to design a definitive study to determine the effects of illicit drugs on pregnancy. The ...

The electrocardiogram continues to be a valuable, noninvasive, easily repeatable, and inexpensive means of diagnosing many cardiac abnormalities, such as myocardial infarction, ischemia, and ventricular hypertrophy, and it is unequaled in the analysis of ...

In the past 30 years we have witnessed an assault on the view that breast cancer can be treated as a regional disease solely by aggressive surgical techniques. First to be challenged and abandoned was radical mastectomy, and soon afterward segmental ...

When there is a proven, effective treatment for a dangerous disease, most physicians will try hard to persuade their patients to accept that treatment even if it is unpleasant and inconvenient. With competent adults, however, it is the patient who decides ...

To the Editor: The American Chiropractic Association is disturbed by the conclusions being drawn about the effectiveness of chiropractic care for the treatment of patients with low back pain on the basis of the study by Cherkin et al. (Oct. 8 issue).¹ ...

To the Editor: The report by Balon et al. (Oct. 8 issue)¹ on a comparison of active and simulated chiropractic manipulation for childhood asthma revealed interesting findings, but the conclusions were confusing and not totally accurate, because of the ...

To the Editor: Indinavir, a human immunodeficiency virus (HIV)–protease inhibitor, improves survival in HIV-infected patients. Although urolithiasis and renal dysfunction are associated with short-term use of indinavir,¹,² no adverse effects have been ...

To the Editor: Rosen and Mark (July 23 issue)¹ did not include dose-intensive chemotherapy or treatment with granulocyte colony-stimulating factor (G-CSF) among the possible causes of atraumatic fat embolism syndrome. We describe two patients with ...

To the Editor: We report an acute allergic reaction to an infusion of dipyridamole. A 56-year-old man was referred for myocardial scintigraphy. He had no history of asthma or diabetes mellitus. His medications included atenolol and gemfibrozil. He had a ...

To the Editor: In 1995 we reported in the Journal the results of a molecular analysis of single Reed–Sternberg cells in biopsy specimens from patients with Hodgkin's disease.¹ Amplified immunoglobulin heavy-chain gene sequences bore the hallmarks of B ...

To the Editor: Cryptococcus neoformans produces a phenol oxidase (laccase) that can synthesize melanin from a variety of substrates. A clinical isolate of C. neoformans was grown in the presence of levodopa and then treated with detergent and hydrogen ...

Our minds live in particular bodies, of course — hence the psychologically shaping influence of biology, as sickness soon enough reminds us. The onset of a disease gives us plenty of opportunity for thought, and in no time, rather often, we are a source ...

In the introduction to his book, psychiatrist Mark Epstein recounts the story of a smart and eager professor who sought wisdom from an old Zen master. The master offered him tea and, on the professor's acceptance, poured the tea into a cup. To the ...

It has been said that the primary function of schools is to impart enough facts to make children stop asking questions. Some, with whom the schools do not succeed, become scientists. I never made good grades in school. At times I nearly failed, and I ...

These three books, which differ so in style and content, are persuasive evidence that the tradition of the physician-author lives on. The beauty of thought and clarity of word they convey merit the attention of any doctor.

Abraham Verghese has already ...

Effect of Matching of Class I HLA Alleles on Clinical Outcome after Transplantation of Hematopoietic Stem Cells from an Unrelated Donor Original Article, N Engl J Med 1998:339;1177-1185.. On page 1177, the sentence that starts on line 7 of the Results ...

Medicaid is the largest health insurer in the United States, in terms of eligible beneficiaries, covering medical services and long-term care for some 41.3 million people. In 1997, Medicaid expended $159.9 billion (12.4 percent of total national health ...