For many years Pneumocystis carinii pneumonia has been the most frequent event defining the presence of the acquired immunodeficiency syndrome (AIDS) among adults in developed countries who are infected with the human immunodeficiency virus (HIV).¹,² P. ...

In 1896, A.B. Marfan described a five-year-old girl with long thin legs that he characterized as “spider-like.”¹ Over the next 50 years, many other features of Marfan's syndrome were described, including dislocated lenses in 1914, autosomal dominant ...

Insulin resistance and compensatory hyperinsulinemia, which can occur in otherwise normal persons, are risk factors for type 2 diabetes mellitus,¹–⁴ dyslipidemia,⁵–⁷ hypertension,⁵–⁷ and atherosclerosis⁵ — a constellation of findings termed syndrome X, or ...

Patients with essential hypertension,¹,² accelerated hypertension,³ or chronic renal failure⁴ have increased sympathetic activity, which contributes not only to their hypertension but also to atherogenesis and cardiac hypertrophy.⁵,⁶ In patients with ...

Figure 1. A 33-year-old man with hemophilia and the acquired immunodeficiency syndrome had a six-hour history of severe right-sided flank pain and right-lower-quadrant pain accompanied by nausea, vomiting, and anorexia. The patient was afebrile and ...

In the past decade clinical and laboratory studies have led to important new insights into the biology of chronic myeloid leukemia (CML). Basic science has defined the molecular pathogenesis of CML as unregulated signal transduction by a tyrosine kinase. ...

Skin cancers, predominantly basal-cell and squamous-cell carcinomas, have accounted for an estimated 40 percent of all cancers in the United States in recent years, and their frequency has been increasing.¹,² The frequency of malignant melanoma, by far ...

Presentation of Case

A 20-year-old woman was admitted to the hospital because of chronic right otitis media.

The patient had been well until one year earlier, when a “bad cold” developed, with a sore throat. The sore throat subsided after one week, but ...

Before the advent of antiretroviral therapy and prophylaxis against Pneumocystis carinii pneumonia, this type of pneumonia ultimately developed in 60 to 80 percent of adult patients with human immunodeficiency virus (HIV) infection in North America and ...

For most of the century after Marfan first described the skeletal features of the condition that bears his name,¹ progress with regard to Marfan's syndrome was marked by incremental increases in the understanding of its skeletal, ocular, and ...

It is not clear why blood pressure increases in patients with chronic renal failure. The most widely advanced explanation is that such increases are due to extracellular volume expansion caused by decreased renal sodium and water excretion, but other ...

As I walk down the halls of the hospital to see my patients, I cannot help but notice a marked change. The sight of a primary care internist taking care of his or her patients while they are hospitalized is becoming increasingly rare, thanks to the ...

To the Editor: The study by Leon et al. (Dec. 3 issue)¹ comparing three antithrombotic-drug regimens — aspirin alone, aspirin and warfarin, and aspirin and ticlopidine — after coronary stenting showed a lower rate of stent thrombosis with aspirin and ...

To the Editor: The study by Furlan et al. (Nov. 26 issue)¹ provides evidence of an inhibitor of von Willebrand factor–cleaving protease in the pathogenesis of thrombotic thrombocytopenic purpura but not of the hemolytic–uremic syndrome. In this study, ...

To the Editor: Burlingham et al. (Dec. 3 issue)¹ provide evidence that the survival rate of kidney grafts from sibling donors with a mismatch of one HLA haplotype was significantly higher if the mismatched haplotype was derived from the mother rather ...

To the Editor: The antiviral, immunomodulatory, and antiproliferative properties of interferon alfa give this cytokine potential therapeutic effects in chronic viral infections and cancers.¹ A major limitation of interferon alfa therapy is its serious ...

To the Editor: In the Images in Clinical Medicine in the December 3 issue,¹ the history and pathologic picture are not consistent with the diagnosis of acute febrile neutrophilic dermatosis but are typical of neutrophilic eccrine hidradenitis, a ...

To the Editor: In their article on competitive athletes with cardiovascular disease (Nov. 26 issue),¹ Maron et al. conclude: “As a result of the decision in Knapp v. Northwestern University, difficult medical decisions involving participation in ...

To the Editor: A 37-year-old man with insulin-dependent diabetes mellitus complicated by end-stage renal disease who had received a second cadaveric kidney transplant four years earlier presented with symptomatic splenomegaly, progressive anemia, ...

Although Jenner first used his smallpox vaccine more than 200 years ago, not until the latter half of this century did the “age of immunizations” begin. No other technological innovation has come close to yielding the public health benefits that are ...

Therapies for viral hepatitis, mainly hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis delta virus (HDV), and hepatitis G virus infection, are a matter of concern for many physicians, not only specialists in gastroenterology and hepatology but ...

Clinicians caring for patients with asthma and allergic diseases have known for several years that major changes are occurring in the diagnosis and treatment of asthma and allergy. First of all, for reasons that are not entirely clear, the prevalence of ...

Acute-Phase Proteins and Other Systemic Responses to Inflammation Review Article, N Engl J Med 1999:340;448-454.. On page 449, in Table 1, under the heading “Proteins whose plasma concentrations decrease,” retinol-binding protein should have appeared. ...