Of the estimated 13,700 women in the United States in whom invasive cervical cancer was diagnosed in 1998,¹ nearly 5000 will ultimately die of the disease because of the inadequacies of current treatment. In the United States, cervical cancer ...

Cervical cancer is the second most frequent cancer among women worldwide and the most frequent cancer among women in Africa, Asia, and South America.¹ In the United States, where screening for cervical cancer is readily available, most women who are found ...

The American Joint Committee on Cancer¹ and the International Federation of Gynecology and Obstetrics define stage IB cervical cancer as invasive cancer that is confined to the cervix, with a depth of more than 5 mm and a width of more than 7 mm. In ...

Despite recent advances in the care of patients with acute coronary disease and the benefits associated with the early use of reperfusion strategies, cardiogenic shock as a complication of acute myocardial infarction continues to be associated with a ...

Congenital hyperinsulinism is characterized by an inappropriate oversecretion of insulin. It is the most common cause of recurrent hypoglycemia in neonates¹,² and can cause irreversible brain damage.¹–³ It is often resistant to medical therapy,¹,⁴ and ...

Figure 1. A 60-year-old chicken farmer was hospitalized with a two-month history of weakness, marked weight loss, and low-grade fever. He had cachexia with diffuse muscle weakness, exaggerated myotatic reflexes, bilateral ankle clonus, and Babinski signs. ...

In the 1950s and 1960s, several inherited disorders of fluid and electrolyte metabolism were described in which the principal disturbance appeared to be a specific functional defect in the renal tubule. For most of these diseases, plausible physiologic ...

Presentation of Case

A 60-year-old woman was admitted to the hospital because of lumbar pain and incontinence of the bladder and bowel.

She had a 20-year history of low back pain with radiation to the buttocks and anterior thighs, for which she took ...

Despite screening programs, approximately 14,000 cases of invasive cervical cancer are diagnosed annually in the United States. In approximately half these cases, locally advanced disease is present at the time of diagnosis. In developing countries, the ...

The risk of hypoglycemia in neonates is high. If their first feeding is delayed for as little as three to six hours after birth, 10 percent of normal neonates cannot maintain plasma glucose concentrations above 30 mg per deciliter (1.7 mmol per liter).¹ ...

“Disease management” is the latest catch phrase in the ever-evolving American health care spectacle. What does it mean? Who is promoting it and why? What does it portend for the future of health care? Disease management has two forms — a contracted “carve-...

To the Editor: Two studies in the November 19 issue, one by McHutchison et al.¹ and one by Davis et al.,² were supported by Schering-Plough and show that combining interferon alfa-2b with ribavirin leads to better virologic and biochemical rates of ...

To the Editor: In his editorial on the appropriate use of carotid endarterectomy (Nov. 12 issue),¹ Dr. Chassin states that “data on the rates of death or stroke within 30 days after surgery, adjusted for the severity of carotid disease and coexisting ...

To the Editor: Ticlopidine is used extensively for patients who undergo coronary angioplasty, stent deployment, or both. Most physicians are well aware of its potential side effects, such as diarrhea, neutropenia, or rash. We describe a case in which ...

To the Editor: Annas discusses a U.S. Supreme Court decision (Oct. 22 issue)¹ that interprets the Americans with Disabilities Act as applied to a dentist, Randon Bragdon, who refused to fill a cavity in a patient who was positive for the human ...

To the Editor: Rarely will a lawyer spell out more honestly, at least in public, the attitude of the legal profession toward medical-malpractice suits than Grad does in his recent review of Damages: One Family's Legal Struggles in the World of Medicine, ...

To the Editor: Human granulocytic ehrlichiosis was first reported in the United States in 1994.¹ Over the past five years at least several hundred cases have been reported, mostly in the upper Midwest and Northeast, regions where other diseases ...

In less than a week, amorphous clusters of mesodermal cells in an early mouse embryo are transformed into a four-chambered heart, complete with valves, coronary vessels, a pacemaker, and a specialized conducting system. At a stage of development when many ...

Many developmental biologists and geneticists have enjoyed reading the literature on the work of Walter Gehring's laboratory. It was thus a great pleasure to peruse a book detailing the behind-the-scenes story of Gehring's seminal contributions to our ...

Of Two Minds breaks new ground. The book's premise is that each hemisphere of the brain contains its own mind and its own distinct personality. In the normal person, the two hemispheres and their respective minds are in balance and interact harmoniously. ...

In A Map of the Mind: Toward a Science of Psychotherapy, Brockman proposes that psychotherapy be established as a prospective science practiced “in accordance with scientific procedure.” He presents a systematic therapeutic approach that draws on ...