Birth defects are likely to recur in families. This pattern probably reflects not only shared genetic factors but also shared environmental factors. Although some studies have documented an increased tendency of women with birth defects to have children ...

Cytomegalovirus retinitis is the leading cause of visual loss in patients with the acquired immunodeficiency syndrome (AIDS).¹–³ Systemic administration of ganciclovir,⁴–⁶ foscarnet,⁴ or cidofovir⁷,⁸ results in the initial control of retinitis. However, ...

Bronchioloalveolar carcinoma is a variant of the adenocarcinoma form of lung cancer (commonly referred to as typical adenocarcinoma). The main pathological findings in this variant are cells with features of a well-differentiated adenocarcinoma, which ...

The secretion of thyrotropin and therefore of thyroid hormone is regulated by triiodothyronine bound to a thyroid hormone receptor, acting at a response element near the transcription start site of the thyrotropin β-subunit gene and perhaps involving ...

Figure 1. A newborn presented with a 9-by-12.5-cm mass in the frontal region that completely covered her right eye (Panel A). The diagnosis of hemangioma was confirmed by ultrasonography and by a skin biopsy that showed lobules of proliferating ...

Since the performance of the first successful lung transplantation nearly two decades ago, the procedure has gained widespread acceptance as a therapeutic option for a diverse array of lung diseases. For patients with severe functional impairment and ...

Eating disorders affect an estimated 5 million Americans every year. These illnesses — anorexia nervosa, bulimia nervosa, binge-eating disorder, and their variants — are characterized by a serious disturbance in eating, such as restriction of intake or ...

Presentation of Case

A 53-year-old man was admitted to the hospital because of acute renal failure, with cortical blindness and respiratory distress.

The patient had been well until five months earlier, when progressive epigastric pain developed. A ...

Most parents of a child with a birth defect focus their attention on short-term considerations regarding the child's health. Once these worries abate, parents begin to think about the child's long-term prognosis. Unfortunately, they are unlikely to find ...

In this issue of the Journal, Martin and colleagues report the success of oral ganciclovir in reducing the risk of cytomegalovirus disease in the initially unaffected eye and other organs of patients with AIDS who have cytomegalovirus retinitis and who ...

In the 19th century, European imperialists obtained control of resources and markets in developing countries to facilitate economic expansion. In 1898, the United States joined the ranks of the imperialists with its efficient victory in the Spanish–...

To the Editor: Publication of the results of biomedical research is not a mere formality in science. It is the culmination of a long process, and careful attention to every step in that process is important.¹ In randomized clinical trials, failing to ...

To the Editor: The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) trial (Nov. 5 issue)¹ is the third study, after the Scandinavian Simvastatin Survival Study² and the Cholesterol and Recurrent Events study,³ on the use of 3-hydroxy-...

To the Editor: The report by Santucci et al. (Nov. 5 issue)¹ provides another example of sources of interference with implantable defibrillators.² That this should occur is not surprising to anyone familiar with the sensing function of medical devices. ...

To the Editor: Kondziolka et al. in their study (Nov. 12 issue)¹ and Pitts and Jackler in their accompanying editorial² miss two important issues concerning radiosurgery for acoustic neuromas. First, since the age of the patient is relevant to the ...

To the Editor: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency results in deficient production of cortisol and aldosterone, chronic stimulation of the adrenal cortex by corticotropin, and overproduction of androgens. Cortisol-replacement ...

To the Editor: A succession of at least 57 moderate-to-severe endotoxin-like reactions has occurred in the western United States over an approximately six-month period. These reactions were associated with the administration of endotoxin-contaminated ...

To the Editor: I was surprised to read that a physician caring for the patient described in Case 35-1998 (Nov. 19 issue)¹ administered lithium to prevent corticosteroid-induced manic symptoms. No reference was given for this intervention, and lithium ...

To the Editor: Unilateral calf swelling is abnormal and a cardinal manifestation of deep-vein thrombosis. The finding of asymmetry of the circumference of the two calves may lead to an extensive and occasionally invasive workup to rule out this potential ...

To the Editor: Hepatocellular neoplasms, peliosis hepatis, and hepatic necrosis have been reported to be complications of long-term therapy with androgenic anabolic steroids.¹ We report a case of a large subcapsular hepatic hematoma and subsequent ...

With an aging population and many infectious diseases now under control, cancer has become a major cause of morbidity and mortality in developed countries. Epidemiologic surveys indicate that the patient with cancer often has a family history of cancer. ...

Justification for a book with the title Comprehensive Geriatric Oncology lies in two demographic trends. The first is the aging of the population. We are in the midst of a serious demographic shift toward an increasing number of older persons in this ...

The editors of The Breast are oriented toward surgery, but the approach is broad. The result is an impressive work in two volumes, written by almost 150 authors. The first volume contains chapters on history, anatomy and physiology, pathology, genetics, ...

The Effect of Race and Sex on Physicians' Recommendations for Cardiac Catheterization Special Article, N Engl J Med 1999:340;618-626.. On page 619, 14 lines from the bottom of the right-hand column, the software program designed by Interactive Drama ...

While concern about the direction of managed care has intensified in the United States,¹ managed care has been diffusing rapidly to other countries. During the late 1980s and early 1990s, reforms in several European national health programs introduced ...