Several large trials have demonstrated that the long-term administration of beta-adrenergic blockers to patients after myocardial infarction improves survival.¹–³ Although the percentage of such patients receiving beta-blockade has recently increased, ...

Each year croup is diagnosed in 3 of every 100 children under six years of age,¹ and approximately 1 percent of children with croup are hospitalized.¹ As a result, it accounts for a substantial proportion of all pediatric hospitalizations (2 percent at ...

Nonoxynol 9 is a nonionic detergent that has been used as a spermicide since the 1950s. By disrupting the membranes of epithelial cells, bacteria, and viruses, nonoxynol 9 inactivates many sexually transmitted pathogens in vitro, including Neisseria ...

The lifetime risk of colorectal cancer among whites in the Western world is approximately 4 percent. The cause of colorectal cancer is multifactorial, involving hereditary susceptibility, environmental factors, and somatic genetic changes during tumor ...

Figure 1. A 42-year-old man with the acquired immunodeficiency syndrome was evaluated for cachexia, hepatosplenomegaly, and persistent fever that was unresponsive to therapy with a third-generation cephalosporin and vancomycin. He had no lumbosacral, ...

Micrococcus, which, when limited in its extent and activity, causes acute suppurative inflammation (phlegmon), produces, when more extensive and intense in its action on the human system, the most virulent forms of septicæmia and pyæmia.¹

In an elegant ...

A decade ago, it was proposed that peripheral arterial vasodilation was an important event in the pathophysiology of ascites formation in patients with cirrhosis.¹ At the same time, nitric oxide was demonstrated to be a potent vasodilator with a major ...

Presentation of Case

A 15-year-old right-handed girl was admitted to the hospital because of hemiparesis, slurred speech, and urinary retention.

The patient had been in excellent health until two and a half weeks earlier, when she began to have urinary ...

During the 1960s, Sir James W. Black developed propranolol, which the Nobel Committee in 1988 called “the greatest breakthrough when it comes to pharmaceuticals against heart illness since the discovery of digitalis 200 years ago.”¹ Black recognized that ...

In this issue of the Journal, Johnson et al. report that in children with moderately severe croup, a single dose of intramuscular dexamethasone (0.6 mg per kilogram of body weight) or nebulized budesonide (4 mg) resulted in significantly fewer ...

More than 20 years have passed since the last case of smallpox was confirmed and 18 years since the International Commission for the Certification of Smallpox Eradication of the World Health Organization (WHO) concluded that the global eradication of ...

To the Editor: The Screening Mammography Program of British Columbia (SMPBC) is a population-based program providing two-view, bilateral mammography to asymptomatic women residing in British Columbia, Canada. Access to annual screening is available to ...

To the Editor: The primary conclusion drawn by the authors of the Thrombolysis or Peripheral Arterial Surgery (TOPAS) trial (April 16 issue)¹ was that recombinant urokinase reduced the need for open surgical procedures. It would have been remarkable if ...

To the Editor: In your editorial “Private Arsenals and Public Peril” (May 7 issue),¹ you state, “Kits to convert semiautomatic weapons into fully automatic machine guns should be outlawed.” In fact, the availability of automatic weapons (i.e., machine ...

To the Editor: I was intrigued by an advertisement in the May 28 issue of the Journal, which read: “If a financially stable health care entity and a safe quality of life appeals to you, send your curriculum vitae to. . . .”

That phrase, “a safe quality ...

Everyone who engages in research, whether original scientific investigations or scholarly studies, knows how easily error creeps into the process. It takes just a momentary diversion, a hidden bias, a casual acceptance of unsubstantiated claims, or a ...

Visitors to the cockpit or sick bay of the U.S.S. Constitution (“Old Ironsides”) in Boston have often wondered what went on in those dim, below-deck spaces. Now their curiosity can be satisfied by J. Worth Estes's cleverly documented book about life and ...

In treating tiny neonates who cannot provide an oral medical history, who are often too small and fragile to handle with ease and safety, and who are cared for in intensive care units equipped with the latest diagnostic equipment, one might justifiably ...

A Vaccine Consisting of Recombinant Borrelia burgdorferi Outer-Surface Protein A to Prevent Lyme Disease Original Article, N Engl J Med 1998:339;216-222.. The names listed in the Appendix should have appeared in a footnote on the first page of the ...