Throughout the world, over 300 million people have chronic infection with hepatitis B virus (HBV), and more than 75 percent of those affected are of Asian origin.¹ Chronic HBV infection causes cirrhosis, liver cancer, and death.²,³ The disease is endemic ...

Diabetic nephropathy is the single most important cause of end-stage renal disease.¹ It results from the gradual accumulation of extracellular matrix in glomerular and tubular basement membranes and mesangial and interstitial tissues, as well as from ...

In 1903 J. Whitridge Williams, in the first edition of his textbook of obstetrics,¹ stated, “During the first stage of labour the patient usually prefers to move about her room, and frequently is more comfortable when occupying a sitting position. During ...

Venous thromboembolism is a common, life-threatening complication in patients undergoing elective neurosurgery. An average incidence of deep-vein thrombosis of 24 percent was found among 474 untreated control patients included in eight studies on the ...

Figure 1. Four weeks after undergoing surgery to remove an intraventricular meningioma, a 64-year-old woman had recurrent episodes of dyspnea and hypotension. Ultrasonography revealed a deep venous thrombosis involving the left popliteal vein. Treatment ...

This year marks the 28th anniversary of my involvement as a medical journalist in television, the first 14 years part time, the last 14 full time as medical editor of ABC News. I here reflect on my experiences in this field, including the dramatic changes ...

The diagnosis and treatment of pulmonary embolism demand an interdisciplinary approach, combining medical, surgical, and radiologic specialties. Despite substantial advances, mortality and recurrence rates remain high. The present article addresses ...

Presentation of Case

A 32-year-old woman was admitted to the hospital because of paresthesias and pharyngeal spasms.

The patient had been in excellent health until 68 days earlier, when she was bitten by a dog in Nepal. She received only first aid. The ...

In this issue of the Journal, Lai et al.¹ report the results of a one-year trial of lamivudine, an oral nucleoside analogue, in patients with chronic hepatitis B infection. The 358 patients were randomly assigned to receive daily lamivudine (25 mg or 100 ...

Hyperglycemia is an important factor in the development and progression of the complications of diabetes mellitus. In this issue of the Journal, Fioretto et al. report that pancreas transplantation reverses the lesions of diabetic nephropathy in patients ...

In 1833, William P. DeWees wrote that during labor “the patient should be directed to keep as quiet as possible and that the preposterous custom of obliging her to walk the floor with a view to increase the pains when tardy should be peremptorily ...

The birth of Dolly, the sheep cloned from a mammary cell of an adult ewe, has initiated a public debate about human cloning. Although cloning of humans may never be clinically feasible, discussion of the ethical, legal, and social issues raised is ...

In February the U.S. Senate voted 54 to 42 against bringing an anticloning bill directly to the floor for a vote.¹ During the debate, more than 16 scientific and medical organizations, including the American Society of Reproductive Medicine and the ...

To the Editor: Estacio et al. (March 5 issue)¹ report an increased incidence of fatal and nonfatal myocardial infarction in patients with hypertension and diabetes who received nisoldipine, in a randomized, prospective, blinded study of moderate as ...

To the Editor: In the February 26 issue, Moliterno et al.¹ report on the reduced expression of the thrombopoietin receptor Mpl as a new characteristic of polycythemia vera and idiopathic myelofibrosis. On the basis of this reduced expression, they ...

To the Editor: Hauser et al. (Feb. 12 issue)¹ reported on a study of the risk of recurrent seizures after two unprovoked seizures. The small number of patients (63) who had a second seizure represented a highly selected group; 41 had a third seizure, and ...

To the Editor: In their excellent review of alcohol problems, O'Connor and Schottenfeld (Feb. 26 issue)¹ discuss several ways to treat the alcohol withdrawal syndrome. Although infrequently used therapies such as carbamazepine are considered, the authors ...

To the Editor: With respect to the image of platelet satellitism presented by Drs. Shahab and Evans (Feb. 26 issue)¹: complexes of platelets and polymorphonuclear neutrophils are not solely an in vitro phenomenon seen in blood treated with EDTA as an ...

To the Editor: Actuarial data indicate that driver-side airbags reduce the overall risk of death from a car accident by 11 percent,¹ but airbag-induced injuries (both fatal and nonfatal) have been reported.² The driver's proximity to the airbag is an ...

On February 27, 1997, Ian Wilmut and his colleagues at an animal-husbandry research center near Edinburgh, Scotland, announced in Nature the birth of Dolly. This was no mere birth notice: Dolly was produced by fusing the nucleus of a cell from the udder ...

There is a need now and again to sit back and contemplate what we do. Science evolves not through a smooth progression of discoveries, but by a series of leaps and bounds. We are currently experiencing a revolution in genetic science. As a consequence, ...

Liver Failure and Death after Exposure to Microcystins at a Hemodialysis Center in Brazil Original Article, N Engl J Med 1998:338;873-878.. On page 876, the sentence that begins two lines from the bottom of the left-hand column should have read, “The ...

Global Surveillance for Antituberculosis-Drug Resistance, 1994–1997 Original Article, N Engl J Med 1998:338;1641-1649.. On page 1641, the sentence that begins on line 9 of the Results paragraph of the Abstract should have read, “Among patients with ...